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Transcatheter arterial chemoembolization (TACE) is the standard treatment for inoperable hepatocellular carcinoma (HCC), of intermediate stage according to BCLC (Barcelona Clinic Live Cancer) system. It is also applied in cases of hemorrhage caused by ruptured HCC, as a bridge therapy prior to transplantation, as a means of downstaging HCC and in post-operation recurrences of the same tumor. TACE is also applied for the treatment of inoperable intrahepatic cholangiocarcinomas and for the treatment of liver metastases, particularly when systemic chemotherapy has failed. Liver metastases most commonly treated with TACE include those from colon cancer and from neuroendocrine tumors. Finally, TACE is associated with a variety of contraindications and complications; a thorough knowledge of them is the cornerstone for an increased efficacy and safety of TACE. [ABSTRACT FROM AUTHOR]