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During 2016-2017 was investigated wild cucumber Echinocystis lobata (Michx) in different habitats as invasive plant and its diseases. The Cladosporium and Alternaria predominated on a wild cucumber but often were found Fusarium. Either virus was investigated. The Cucumber Mosaic Virus was detected in wild cucumber transplants grown from earlier collected seeds in field crop rotation. Arabis Mosaic Nepovirus was found in cucumber hybrid leaves, produced in the commercial greenhouse. E. lobata plants have almost no natural enemies. Therefore, either viral or fungal disease helps to maintain the natural balance of the ecosystem. [ABSTRACT FROM AUTHOR]