Search

Under certain pathologic conditions AGEs formation can be increased beyond normal levels.The purpose of the study was to investigate essential RF and AGEs before, immediately after and 2 days after runs. Nine trained runners (43±9yr) during 9.5 km and 13 trained runners (48±11yr) during 16.3 km long-distance runs were investigated. Standard blood and urinary RF parameters were investi-gated in all runners using spectrophotometric methods by Roche analyzer Integra 800.Serum cystatin C was determined using immu-noturbidimetric method (PETIA Gentian). Plasma AGEs and malon-dialdehyde (MDA) were determined by spectrofluorimetric methods, Nε-carboxylmethyllysine using ELISA method and advanced oxidation protein products(AOPPs) using spectrophotometric method. Total proteinuria was 0.46±0.4 g/L after 9.5 km run and 0.35±0.3 g/L after 16.3 km run. Serum urea and creatinine significantly increased after both runs (creatinine in 28% after 9.5 km and in 41% after 16.3 km run). Estimated glomerular filtration rate (eGFR) MDRD and eGFR-PETIA significantly decreased after both runs (9.5 km: in 27.6% resp. 21.3% and 16.3 km: in 34,6% resp. 30.3%, p