Search

More than a half of patients starting dialysis are found to have a poor predialysis nutritional status. A low-protein diet (LPD) delays CKD progression but occasionally lead to some changes in body composition and malnutrition. We performed a prospective, open-label, parallel, randomized and controlled trial to compare a body composition and biochemical parameters of CKD patients who were on LPD supplemented with ketoanalogues of essential aminoacids (KA) with those on a free diet (FD). Biochemical and bioimpedance parameters were analyzed in CKD patients every month before initiation of dialysis. Impedance measurements were performed with a multifrequency bioelectrical impedance analyzer. Group I (n=14 patients, 8 male, 6 female; 53 ±12 y.o; glomerular filtration rate (GFR) 18,8 ± 6,3 ml/min (MDRD formula) ) having LPD (0.5 g/kg/day protein) supplemented with KA (1 tablet/5 kg of body weight a day) was compared with matched Group II on FD (n=15 CKD patients with GFR 17,8±5,9 ml/min). Protein intake was lower in patients on LPD (0,5±0,1 g/kg/day protein) than on FD (1,14±0,21g/kg/day; p