Search

In this study, the solute transfer examinations were performed both with a piece of artificial membrane and with a modeled peritoneal membrane. The former included permeation experiment for reatinine with and without irradiating ultrasound (45, 100 kHz). Results showed that the rate of permeation was promoted with ultrasound of 45 kHz and at the same time, destruction of membrane was also observed. The latter experiment also included a solute permeation with a modeled peritoneum that was constructed from Normal Human Dermal Fibroblasts (NHDF) and Human Umbilical Vein Endothelial Cells (HUVEC). Methyl glyoxal (MGO), a possible toxin for the peritoneum, was exposed for 24 hours against to the modeled peritoneum. Result showed that NHDF is weaker to MGO than HUVEC. In both studies, enhancement of permeation due to external stimuli was observed.