13 results on '"Yago T"'
Search Results
2. [An asymptomatic mother of cutaneous neonatal lupus child was diagnosed with Sjögren's syndrome suspected].
- Author
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Nanke Y, Yago T, and Kotake S
- Subjects
- Adult, Female, Humans, Infant, Newborn, Infant, Newborn, Diseases genetics, Lupus Erythematosus, Cutaneous genetics, Sjogren's Syndrome diagnosis
- Abstract
We report an asymptomatic mother of a cutaneous neonatal lupus child was diagnosed with Sjögren's syndrome suspected after parturition. A 30-year old woman was visited our hospital to evaluated autoimmune disease because her baby was diagnosed as cutaneous neonatal lupus. Both gum test and Schirmer's test were positive. Antinuclear antibody, anti-SS-A and anti-SS-B antibody were positive. Serum IgG was elevated (2918 mg/dl). Finally, this case was suspected as Sjögren's syndrome. Continuoues follow-up of asymptomatic mothers of a neonatal lupus child is warranted.
- Published
- 2010
- Full Text
- View/download PDF
3. [Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis].
- Author
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Kotake S, Yago T, Kawamoto M, and Nanke Y
- Subjects
- Animals, Haplorhini, Humans, Lung Neoplasms genetics, Lung Neoplasms pathology, Mice, Proteins metabolism, Small Cell Lung Carcinoma genetics, Small Cell Lung Carcinoma pathology, Synovial Membrane metabolism, Arthritis, Rheumatoid genetics, Arthritis, Rheumatoid physiopathology, Bone Resorption genetics, Cell Differentiation genetics, Osteoclasts cytology, Proteins physiology
- Abstract
Synovial tissues of patients with rheumatoid arthritis (RA) include factors regulating bone resorption, such as receptor activator NF-kappaB ligand (RANKL), TNF-alpha, IL-6, IL-17, and IFN-gamma. However, in addition to these cytokines, other factors expressed in synovial tissues may play a role in regulating bone resorption. In 2009, we demonstrated that novel peptides from T-cell leukemia translocation-associated gene (TCTA) protein expressed in synovial tissues from patients with RA inhibit human osteoclastogenesis, preventing cellular fusion via the interaction between TCTA protein and a putative counterpart molecule. Only a few studies on the role of TCTA protein have been reported, including our report published in 2009. In the current review paper, we summarized papers on TCTA protein before 2009 and our recent findings.
- Published
- 2009
- Full Text
- View/download PDF
4. [Effects of biologic therapies on systemic osteoporosis in patients with rheumatoid arthritis].
- Author
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Kotake S, Yago T, and Nanke Y
- Subjects
- Antibodies, Monoclonal therapeutic use, Antibodies, Monoclonal, Humanized, Denosumab, Diterpenes, Drug Design, Humans, Infliximab, Interleukin-1 physiology, Interleukin-17 physiology, Interleukin-6 physiology, Osteoclasts, RANK Ligand immunology, RANK Ligand physiology, RANK Ligand therapeutic use, Receptors, Interleukin-6 immunology, Tumor Necrosis Factor-alpha immunology, Tumor Necrosis Factor-alpha physiology, Arthritis, Rheumatoid drug therapy, Arthritis, Rheumatoid etiology, Osteoporosis drug therapy, Osteoporosis etiology
- Abstract
Biologic therapies including tumor necrosis factor alpha (TNF-alpha)-blocking therapy have been shown to reduce disease activity measures and joint damage progression. However, effects of biologic therapies on systemic osteoporosis remain to be elucidated in patients with rheumatoid arthritis (RA). In this review article, we reviewed the literature on the issue after we described our hypothesis on the pathogenesis of synovitis in patients with RA.
- Published
- 2009
5. [Serum markers of synovitis and bone metabolism in rheumatoid arthritis].
- Author
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Kotake S, Nanke Y, Yago T, and Yamanaka H
- Subjects
- Alkaline Phosphatase blood, Antibodies, Monoclonal therapeutic use, Antibodies, Monoclonal, Humanized, Arthritis, Rheumatoid drug therapy, Biomarkers blood, Bone Density, Collagen Type I blood, Denosumab, Etanercept, Humans, Immunoglobulin G therapeutic use, Infliximab, Osteocalcin blood, Peptides blood, RANK Ligand therapeutic use, Receptors, Tumor Necrosis Factor therapeutic use, Synovitis etiology, Tumor Necrosis Factor-alpha antagonists & inhibitors, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid metabolism, Bone Resorption, Matrix Metalloproteinase 3 blood, Osteogenesis, Synovitis diagnosis
- Abstract
Matrix metalloproteinase-3 (MMP-3) is a useful marker to evaluate the prognosis of joint destruction in rheumatoid arthritis (RA) . The role of MMP-3 in immune cells, however, remains to be elucidated in the pathogenesis of RA. On the other hand, biologic therapies, including tumor necrosis factor alpha (TNF-alpha) -blocking therapy, has been shown to reduce disease activity measures and joint damage progression ; however, the effects of biologic therapies on systemic osteoporosis remain to be elucidated in RA. In this article, we reviewed the literature on these issues after describing our hypothesis of the pathogenesis of synovitis in RA.
- Published
- 2009
6. [A case of ophthalmic artery obstruction following autologous fat injection in the glabellar area].
- Author
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Mori K, Ohta K, Nagano S, Toshinori M, Yago T, and Ichinose Y
- Subjects
- Adult, Blindness etiology, Female, Humans, Postoperative Complications, Transplantation, Autologous, Vascular Diseases etiology, Ophthalmic Artery, Subcutaneous Fat transplantation, Surgery, Plastic adverse effects
- Abstract
We report a case of blindness due to occlusion of the ophthalmic artery following injection of autologous fat into the glabellar region for cosmetic surgery. A 30-year-old woman underwent aspiration of autologous fat from her gluteal region and injection of it into her breasts, nose, and glabellar area. At the time of injection into the glabellar area, she suffered nausea, pain, and visual loss in her right eye. She consulted an ophthalmologist. The first examination revealed that her right eye had loss of light perception, widespread retinal whitening, and obstruction of the retinal vessels of the fundus. It was suspected that she had occlusion of the central retinal artery, and drip infusion of urokinase and hyperbaric oxygen therapy were implemented. Since no improvement was seen, she was referred to Shinshu University hospital. Fundoscopy showed remarkable edema of the entire right retina and whitened retinal vessels. Fluorescein angiography showed no filling of the right retinal arterioles. Cerebral angiography showed complete obstruction of the right ophthalmic artery at its bifurcation. Subsequent administration of urokinase and corticosteroid had no effect. We considered that occlusion of the ophthalmic artery happened when autologous fat was injected into the glabellar area.
- Published
- 2007
7. [A case of vasculitis syndrome associated with bronchiolitis obliterans organizing pneumonia (BOOP)].
- Author
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Yago T and Nishinarita M
- Subjects
- Adult, Humans, Male, Cryptogenic Organizing Pneumonia complications, Vasculitis complications
- Abstract
In 1996 36-year-old man was admitted into our hospital because of polyarthralgia, skin eruptions followed by multiple cutaneous ulcers, dry cough and elevation of C-reactive protein level. The finding of skin biopsy from left elbow was vasculitis. Chest CT showed linear interstitial shadow at bilateral dorsalis lungs. Transbronchial lung biopsy (TBLB) revealed marked infiltration of inflammatory cells in the bronchial walls and peripheral alveoli. In addition, eosinophils were not in branchoalveolar lavage (BAL) fluid. Moreover, video-assisted thoracic surgery (VATS) revealed organizing fibroblastic polyp and bronchiolitis obliterans at terminal bronchiole. We diagnosed his pneumonia as bronchiolitis obliterans organizing pneumonia (BOOP). Administration of oral prednisolone (40 mg/day) was begun and he experienced diminished BOOP and other clinical manifestations. Three years later he developed dry cough, dyspnea and digital ulcers again. Arterial blood gas analysis revealed marked hypoxemia and laboratory studies showed LDH (377 IU/ml) and CRP (8.27 mg/dl) levels were elevated. Chest CT pointed out an exacerbation of BOOP. Treatment with intravenous pulses methylprednisolone and oral prednisolone (60 mg/day) resulted in marked improvement of the clinical manifestations. We describe a rare case of vasculitis associated with BOOP.
- Published
- 2004
- Full Text
- View/download PDF
8. [A case of Sjögren's syndrome with marked lacrimal gland enlargement, atypical onset and IgA-M-proteinemia].
- Author
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Yago T and Nishinarita M
- Subjects
- Aged, Antibodies, Antinuclear, Humans, Hypertrophy etiology, Male, Paraproteinemias blood, Sjogren's Syndrome diagnosis, Sjogren's Syndrome physiopathology, Immunoglobulin A blood, Immunoglobulin mu-Chains blood, Lacrimal Apparatus pathology, Paraproteinemias etiology, Sjogren's Syndrome complications
- Abstract
Since July, 1999, a 66 year-old man had been complaining of dry cough. He noticed submandibular swelling, lacrimal gland enlargement and dry eye. Keratoconjuctivitis sicca was detected by an ophthalmologist. Sjögren's syndrome was diagnosed based on microscopic findings of a labial salivary gland biopsy although anti-SS-A and anti-SS-B antibodies were negative. Hypergammaglobulinemia (IgG 3916 mg/dl) and IgA-M-proteinemia were pointed out. Swelling of mediastinal and abdominal lymph nodes was detected together with enlargement of salivary and lacrimal glands. We suspected the existence of malignant lymphoma, but a biopsy of lacrimal glands showed only lymphocytic and plasma cell infiltration and immunohistochemical analysis denied monoclonality of lymphoid line. An administration of corticosteroids caused rapid diminution in size of lacrimal and submandibular glands and lymph nodes. Clinical symptoms were also improved, but IgA-M proteinemia remains. The characteristics of our case were enlargement of lacrimal glands, the negativity of anti SS-A and SS-B antibodies, atypical onset and M-proteinemia. We discussed about these characteristics of Sjögren's syndrome in our case.
- Published
- 2002
- Full Text
- View/download PDF
9. [A case of systemic sclerosis complicated by Takayasu's arteritis].
- Author
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Yago T, Ota S, and Nishinarita M
- Subjects
- Aged, Female, Humans, Scleroderma, Systemic complications, Takayasu Arteritis complications
- Abstract
We report a case of systemic sclerosis complicated by Takayasu's arteritis. A 68-year-old woman had been treated for hypertension since 1984. She also had Raynaud's phenomenon and noticed vertigo and dizziness. In January 1992, she was diagnosed with back bruit. In April 1994, she was complicated by vertigo and diagnosed with asymmetrical blood pressure. In October 1998, she consulted our hospital because of neck bruit, abdominal bruit, back bruit and stenosis of descending aorta bifurcation on chest computed tomography. Her blood pressure was asymmetrical, being recorded as 190/101 on the right and 140/90 on the left. Scleroderma was observed from the finger to forehand, precordia, and face. Telangiectasia was observed on the precordia. Laboratory studies revealed the presence of anti-nuclear antibody (x 1280, discrete speckled.), anti-centromere antibody but anti-topoisomerasel antibody was negative. Skin biopsy from the left forehand detected proliferation of collgen fibers and perivascular inflammatory cell infiltration. A diagnosis of systemic sclerosis was made according to the American Rheumatism Association criteria. We suspected complication by Takayasu's arteritis because of asymmetrical blood pressure and bruit. Chest-abdominal angiography detected stenosis of the right brachiocephalic trunk, celiac artery, and left renal artery. We diagnosed Takayasu's arteritis. This is the second case report of a patient with systemic sclerosis complicated by Takayasu's arteritis.
- Published
- 2002
10. [A randomized crossover comparison of azasetron and granisetron in the prophylaxis of emesis induced by chemotherapy including cisplatin].
- Author
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Tsukuda M, Mochimatsu I, Furukawa M, Kohno H, Kawai S, Enomoto H, Yago T, Matsuda H, Ikema Y, and Zhou L
- Subjects
- Aged, Female, Head and Neck Neoplasms drug therapy, Humans, Male, Middle Aged, Vomiting chemically induced, Antiemetics therapeutic use, Bridged Bicyclo Compounds, Heterocyclic therapeutic use, Cisplatin adverse effects, Granisetron therapeutic use, Oxazines therapeutic use, Serotonin Antagonists therapeutic use, Vomiting prevention & control
- Abstract
The clinical application of 5-HT3 receptor antagonists has enabled continuation of the course of chemotherapy including cisplatin, which induces strong nausea and vomiting, and to prevent the delay of curative treatment for cancer patients receiving neoadjuvant chemotherapy. However, with the development of basic research on the mechanisms of vomiting, each 5-HT3 receptor antagonist has appeared to have different pharmacological actions and, subsequently, the difference in the clinical efficacy of each drug has been reported in Europe and USA. In freshly advanced head and neck carcinoma cases, a randomised crossover study was performed to compare the efficacy and safety profile of a single intravenous dose for 7 days of azasetron (10 mg/day) or granisetron (3 mg/day) in the prophylaxis of nausea and vomiting induced by multi-drug chemotherapy including cisplatin (50 mg/m2 or 60 mg/m2). Anti-emetic effects were evaluated by the protective rates for nausea and vomiting for 7 days following the start of cisplatin administration. Both 5-HT3 receptor antagonists were highly effective in the prophylaxis of acute and delayed emesis induced by chemotherapy, whereas the efficacies of azasetron on day 3 and 4 were superior to those of granisetron. No adverse effect of either drug was observed in this study.
- Published
- 1995
11. [Comparison of granisetron alone and granisetron plus dexamethasone or hydroxyzine hydrochloride for the prevention of nausea and vomiting during chemotherapy including cisplatin].
- Author
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Tsukuda M, Kohno H, Enomoto H, Kawai S, Yago T, Matsuda H, Ikema Y, Makino Y, Kubota A, and Furukawa M
- Subjects
- Adult, Aged, Carcinoma, Squamous Cell drug therapy, Drug Therapy, Combination, Female, Fluorouracil administration & dosage, Head and Neck Neoplasms drug therapy, Humans, Male, Middle Aged, Cisplatin adverse effects, Dexamethasone administration & dosage, Granisetron administration & dosage, Hydroxyzine administration & dosage, Nausea prevention & control, Vomiting prevention & control
- Abstract
The comparative study among granisetron alone and granisetron combined with hydroxyzine hydrochloride or dexamethasone was undertaken for the prevention of nausea and vomiting during chemotherapy including cisplatin in patients with advanced head and neck carcinomas. The results indicated that the combination antiemetic therapies were more effective than granisetron alone for acute nausea and vomiting, whereas a significant difference was not observed among these three groups in the acute adverse effects. Otherwhile, there were statistically significant improvements in the prevention of delayed nausea and vomiting for patients receiving granisetron combined with the other antiemetic drugs, especially the combination antiemetic therapy with dexamethasone. These results confirm the antiemetic activity of granisetron in acute nausea and vomiting induced by cisplatin and show that it has an additive effect in combination with dexamethasone.
- Published
- 1995
12. [The expression of ICAM-1 on head and neck squamous cell carcinoma cell lines].
- Author
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Yago T, Tukuda M, Mochimatu I, Mikami Y, and Sakumoto M
- Subjects
- Cell Line, Humans, Intercellular Adhesion Molecule-1, Interferon-gamma pharmacology, Tumor Cells, Cultured, Carcinoma, Squamous Cell chemistry, Cell Adhesion Molecules analysis, Head and Neck Neoplasms chemistry
- Abstract
Intercellular adhesion molecule-1 (ICAM-1) is one of the cell adhesion molecules. This molecule is a glycoprotein of about 90 KDa belonging to the immunoglobulin (Ig) superfamily and is widely expressed by hematopoietic and non-hematopoietic cells which play a role in the immune system. ICAM-1 is also a ligand or counter-receptor for the leukocyte integrin lymphocyte-function associated antigen-1 (LFA-1). We investigated the expression of ICAM-1 on the surfaces of cells from fifteen head and neck squamous carcinoma cell lines and the modulation of ICAM-1 expression by IFN-gamma, using an immunohistochemical stain. We categorized four types of stain degree. (-): < 10% of cells positive (+/-): 10-40% of cells positive (+): < 40-70% of cells positive (++): > 70% of cells positive Four cell lines showed (-) type. Three cell lines: (+/-). One cell line: (+). Seven cell lines: (++). The primary site of cell lines and the degree of ICAM-1 expression were not detectable. Connection between pathological differentiation and the degreed expression were not apparent, either. IFN-gamma up-regulated the degree of ICAM-1. All cell lines, when stimulated by IFN-gamma, showed (++) type.
- Published
- 1993
- Full Text
- View/download PDF
13. [Angiogenesis in head and neck tumor].
- Author
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Mikami Y, Tsukuda M, Mochimatsu I, Kokatsu T, Yago T, and Sawaki S
- Subjects
- Adult, Aged, Carcinoma, Squamous Cell pathology, Cell Division, Female, Head and Neck Neoplasms pathology, Humans, Lymphatic Metastasis, Male, Middle Aged, Prognosis, Carcinoma, Squamous Cell blood supply, Head and Neck Neoplasms blood supply, Neovascularization, Pathologic pathology
- Abstract
To clarify the correlation between tumor angiogenesis and tumor growth in head and neck carcinomas, we investigated the number of microvessels, using immunohistochemical factor VIII. No correlations among this number, differences in the primary lesion, histological differentiation and T classification were detected. The incidence of neck lymph node metastases increased as microvessel numbers increased in tumor sites. The number of microvessels increased as N and Stage classification progressed. The number of microvessels in CR cases after induction chemotherapy were increased. The numbers of microvessels in patients without recurrence were apparently greater than those in patients with recurrence. The results of this study suggest that the number of microvessels in a primary tumor correlates with the metastatic ability of the tumor.
- Published
- 1993
- Full Text
- View/download PDF
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