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Two autopsy cases (69 and 87-year-old women) of malignant mixed müllerian tumor (MMMT) following radiation therapy for uterine cervical cancer sixteen and twenty years ago respectively were reported. They were admitted due to abdominal pain and diagnosed as ileus. In the first case, CT examination revealed a tumor measuring about 8 x 10 cm in size in the uterine posterior wall. Recurrence of the uterine cancer was suspected and hysterooophorectomy combined with sigmoidectomy was performed. In the second case, artificial anus formation was performed because of sigmoid stricture by the invasion of the tumor. Histologically, tumors in both cases were composed of carcinomatous and sarcomatous components including heterologous elements such as cartilage. The patients died of extensive spreads and metastasis in the liver and alimentary tract.

Although sensory neural hearing loss stemming from hypercholesterolemia has received attention in recent years, no information is available about inner ear injuries resulting from this condition. In this study, we prepared guinea pig models at hypercholesterolemia and observed the inner ear with a transmission electron microscope, and also investigated the effect of vitamin E (Vit. E) on these injuries. One hundred and thirty-nine white male Hartley guinea pigs weighing a mean of 250 g each were divided into three groups. Group A consisted of the control animals, which were fed by a stock diet. Group B animals were fed by a hyperlipid diet (2.5% cholesterol, 0.25% cholic acid, and 7.5% cattle fat). Group C animals were fed by a Vit. E-added (50 units/100 g) hyperlipid diet. All the animals were sacrificed either one, two or three months after treatment and the cochlea duct vasculature, cochleal nerve fiber under spiral limbus, stria vascularis and inner hair cell and outer hair cell of Corti's organ was observed with a transmission electron microscope. Cholesterol, triglyceride, and TBARS values were concurrently measured in the serum. Auditory threshold was measured by auditory brain stem response (ABR). In groups B and C, cholesterol and triglyceride levels remained high,. The TBARS level elevated in group B but remained unchanged in groups A and C. In groups B and C, the threshold of ABR increased mildly. The cholesterol load led to injuries in the endothelium of the vasculature dominating the cochlea.(ABSTRACT TRUNCATED AT 250 WORDS)