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10. [Transdisciplinary Approach for Sarcopenia. The effects of exercise on skeletal muscle hypertrophy and satellite cells].

Author

Fujimaki S, Takemasa T, and Kuwabara T

Subjects
Aging, Cell Death, Humans, Muscular Atrophy metabolism, Signal Transduction, Exercise, Muscular Atrophy therapy, Sarcopenia therapy, Satellite Cells, Perineuronal cytology, Satellite Cells, Perineuronal metabolism
Abstract

Skeletal muscle has a high degree of plasticity. The mass of skeletal muscle maintains owing to muscle protein synthesis and the regeneration by satellite cells. Skeletal muscle atrophy with aging (sarcopenia) is developed by decline of muscle protein synthesis and dysfunction of satellite cells. It is urgently necessary for today's highly aged society to elucidate the mechanism of sarcopenia and to establish prevention measure. This review shows that the positive effects of "exercise" on muscle protein synthesis and satellite cell function including their main molecular mechanism.

Published
2014
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