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Your search keyword '"Sasakura, Y"' showing total 3 results
Start Over Author "Sasakura, Y" Language japanese
3 results on '"Sasakura, Y"'

1. [A Case of Duodenal Perforation during Bevacizumab Combination Chemotherapy in a Patient with Multiple Lung Metastasis after a Sigmoidectomy].

Author

Suzumura H, Shinozaki H, Kondo R, Yamaguchi M, Torizaki Y, Ozawa Y, Futoh Y, Matsuoka T, Matsumoto K, Inoue M, Sasakura Y, Terauchi T, Kimata M, Furukawa J, Kobayashi K, and Ogata Y

Subjects
Aged, Antineoplastic Combined Chemotherapy Protocols, Colon, Sigmoid, Humans, Male, Bevacizumab adverse effects, Duodenal Ulcer, Intestinal Perforation, Sigmoid Neoplasms therapy
Abstract

A 73-year-old man underwent laparoscopic sigmoidectomy for sigmoid colon cancer. Two years after the operation, multiple lung metastasis was diagnosed and chemotherapy with bevacizumab, irinotecan, and TS-1®was started in the patient. However, epigastric pain developed 73 days after the initial course of chemotherapy. Abdominal CT revealed duodenal perforation and generalized peritonitis. Emergency operation with omental patch closure was immediately performed. The patient was discharged 15 days after the emergency operation without any complication. This is an extremely rare case of bevacizu- mab-related duodenal perforation.

Published
2019

2. [A Case of Fournier's Gangrene Caused by Small Intestinal Perforation during Bevacizumab Combination Chemotherapy].

Author

Ishida T, Shinozaki H, Ozawa H, Kobayashi T, Kato S, Wakabayashi T, Matsumoto K, Sasakura Y, Shimizu T, Terauchi T, Kimata M, Furukawa J, Kobayashi K, and Ogata Y

Subjects
Antineoplastic Combined Chemotherapy Protocols administration & dosage, Bevacizumab administration & dosage, Chemoradiotherapy, Drainage, Fatal Outcome, Fluorouracil administration & dosage, Humans, Leucovorin administration & dosage, Male, Middle Aged, Organoplatinum Compounds administration & dosage, Rectal Neoplasms diagnostic imaging, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bevacizumab adverse effects, Fournier Gangrene etiology, Intestinal Perforation chemically induced, Intestine, Small diagnostic imaging, Rectal Neoplasms therapy
Abstract

A 51-year-old man underwent abdominoperineal resection for advanced rectal cancer at a hospital. He attended our outpatient clinic 58 months later with pain in the external genitalia, and was diagnosed with local pelvic recurrence and metastasis to the para-aortic lymph node and both adrenal glands. He received a total of 30 Gy of radiation for analgesia; subsequently, chemotherapy(mFOLFOX6 plus bevacizumab)was initiated. However, extreme left buttock and left femoral pain developed after the 6 courses of chemotherapy. Abdominal CT revealed Fournier's gangrene caused by small intestinal perforation. Emergency drainage under spinal anesthesia was immediately performed. Two additional drainage procedures were required thereafter and an ileostomy was constructed. The patient was discharged 100 days after the initial drainage. This is an extremely rare example of a bevacizumab-related small intestinal perforation that developed into Fournier's gan- grene.

Published
2016

3. [A redox sensing heme-protein from Escherichia coli, Ec DOS: regulation mechanism of phosphodiesterase activity].

Author

Yoshimura-Suzuki T, Sasakura Y, Sagami I, and Shimizu T

Subjects
Binding Sites, Carrier Proteins chemistry, Escherichia coli Proteins chemistry, Heme metabolism, Heme-Binding Proteins, Type III Secretion Systems, Bacterial Proteins physiology, Carrier Proteins physiology, Escherichia coli enzymology, Escherichia coli genetics, Escherichia coli Proteins physiology, Hemeproteins physiology, Oxidation-Reduction, Phosphoric Diester Hydrolases metabolism
Published
2005

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