1. [Sevelamer hydrochloride prevents ectopic calcification of blood vessels].
- Author
-
Fukushima N and Nagano N
- Subjects
- Adsorption, Animals, Aorta, Calcium blood, Clinical Trials as Topic, Disease Models, Animal, Epoxy Compounds pharmacology, Humans, Hydrogen Bonding, Ions, Kidney Failure, Chronic complications, Ossification, Heterotopic etiology, Phosphorus blood, Phosphorus Metabolism Disorders etiology, Phosphorus Metabolism Disorders prevention & control, Polyamines, Polyethylenes pharmacology, Renal Dialysis adverse effects, Risk Factors, Sevelamer, Epoxy Compounds therapeutic use, Ossification, Heterotopic prevention & control, Polyethylenes therapeutic use
- Abstract
Sevelamer hydrochloride is a non-absorbed calcium- and metal-free phosphate binder that lowers the serum phosphorus levels in hemodialysis patients. Sevelamer contains multiple amines, which are partially protonated and interact with phosphate molecules through ionic and hydrogen bonding. We show the in vitro phosphate binding assay data and the efficacy of sevelamer to lower the serum phosphorus and calcium phosphorus product in several animal models. Furthermore, we indicate the vivid data that sevelamer prevented the ectopic calcification of aorta in adenine induced renal failure model, which represent severe hyperphosphatemia and the related dialysis complications.
- Published
- 2004
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