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Your search keyword '"Phosphatidylinositol Phosphates metabolism"' showing total 6 results
Start Over Descriptor "Phosphatidylinositol Phosphates metabolism" Language japanese
6 results on '"Phosphatidylinositol Phosphates metabolism"'

1. [Transport of PIP3 mediated by kinesin regulates neuronal cell polarity].

Author

Yamada KH, Hanada T, and Chishti AH

Subjects
Animals, Biological Transport, Dendrites metabolism, Kinesins metabolism, Microtubules metabolism, Multiprotein Complexes physiology, Neurons cytology, Neurons metabolism, Phosphatidylinositol Phosphates physiology, Protein Binding, Sarcoplasmic Reticulum metabolism, Signal Transduction physiology, Cell Polarity physiology, Kinesins physiology, Neurons physiology, Phosphatidylinositol Phosphates metabolism
Published
2007

2. [Regulation of insulin signaling and its disorder].

Author

Araki E and Kondo T

Subjects
Active Transport, Cell Nucleus, Animals, Appetite, DNA-Binding Proteins metabolism, Humans, Hypothalamus, Insulin Receptor Substrate Proteins, Insulin Resistance, Intracellular Signaling Peptides and Proteins, Leptin physiology, Phosphatidylinositol 3-Kinases metabolism, Phosphatidylinositol Phosphates metabolism, Phosphoproteins physiology, Receptor, Insulin genetics, Receptor, Insulin physiology, STAT3 Transcription Factor, Signal Transduction physiology, Trans-Activators metabolism, Insulin physiology, Signal Transduction genetics
Published
2005
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3. [From the structure to the function of the PX domain].

Author

Kohda D

Subjects
Cell Membrane metabolism, Humans, NADPH Oxidases chemistry, NADPH Oxidases metabolism, Phagocytes enzymology, Phosphatidylinositol Phosphates metabolism, Phosphoproteins chemistry, Protein Binding, Protein Conformation, Protein Structure, Secondary, Superoxides metabolism, src Homology Domains physiology, Homeodomain Proteins chemistry, Homeodomain Proteins physiology
Published
2002

4. [PTEN tumor suppressor: functions as a lipid phosphatase].

Author

Maehama T and Dixon JE

Subjects
Animals, Apoptosis physiology, Cell Division physiology, Cell Movement physiology, Humans, PTEN Phosphohydrolase, Phosphorylation, Signal Transduction physiology, Genes, Tumor Suppressor physiology, Phosphatidylinositol Phosphates metabolism, Phosphoric Monoester Hydrolases physiology, Protein Tyrosine Phosphatases physiology, Tumor Suppressor Proteins
Published
2000

5. [PI3-kinase superfamily: structures and functions].

Author

Kimura K and Fukui Y

Subjects
Amino Acid Sequence, Animals, DNA Repair, GTP-Binding Proteins, Humans, Immunosuppressive Agents pharmacology, Phosphatidylinositol 3-Kinases, Phosphatidylinositol Phosphates metabolism, Phosphotransferases (Alcohol Group Acceptor) genetics, Polyenes pharmacology, Sequence Homology, Amino Acid, Signal Transduction drug effects, Sirolimus, Phosphotransferases (Alcohol Group Acceptor) chemistry, Phosphotransferases (Alcohol Group Acceptor) physiology
Published
1996

6. [Signal transduction of prostaglandin E2 and thromboxane A2].

Author

Nakahata N

Subjects
Animals, Cyclic AMP metabolism, Cyclic AMP physiology, GTP-Binding Proteins physiology, Humans, Inositol Phosphates metabolism, Phosphatidylinositol 4,5-Diphosphate, Phosphatidylinositol Phosphates metabolism, Receptors, Prostaglandin physiology, Receptors, Thromboxane, Second Messenger Systems, Type C Phospholipases metabolism, Dinoprostone physiology, Signal Transduction, Thromboxane A2 physiology
Abstract

The signal transduction of prostaglandin E2 (PGE2) and thromboxane A2 (TXA2), cyclooxygenase products of arachidonic acid, was investigated in smooth muscle preparations and 1321N1 human astrocytoma cells. While PGE2 has been known to stimulate (via EP2 receptor) or inhibit (via EP3 receptor) adenylate cyclase, PGE2 activated phosphatidylinositol 4,5-bisphosphate (PIP2)-specific phospholipase C (PLase C) in non-vascular smooth muscles (via EP1 receptor), resulting in accumulations of inositol trisphosphate (IP3) and diacylglycerol to elicit intracellular Ca2+ mobilization. On the other hand, STA2, a TXA2 receptor analogue, also accumulated IP3 in human astrocytoma cells. [3H]SQ 29548, a TXA2 receptor antagonist, specifically bound to astrocytoma membranes. TXA2-receptor antagonists (ONO NT-126, S-145, SQ29548 and ONO3708) concentration-dependently inhibited PIP2-specific PLase C activation by STA2, and they also inhibited [3H]SQ 29548 binding in human astrocytoma cells. The Ki value of each antagonist in PIP2-specific PLase C inhibition was similar to that in [3H]SQ29548 binding inhibition. In membrane preparations, STA2 activated PIP2-specific PLase C in the presence of GTP gamma S. Pertussis toxin (IAP) did not affect STA2-induced PLase C activation. The results suggest that stimulation of TXA2 receptors activates PIP2-specific PLase C via an IAP-insensitive G-protein.

Published
1992
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