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In the advent of the aging society, the lifetime of artificial joints is a matter of concern. The major cause of revision surgery is periprosthetic osteolysis caused by polyethylene wear particles. To prevent osteolysis, both the reduction of wear and the suppression of osteoclast induction are necessary. For these purposes, we developed a new technology for grafting 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer on the surface of polyethylene liners. On the basis of encouraging results of the preclinical studies, we have started a large-scale clinical trial of new artificial hip joints since 2007.

Three elements contribute to the neurologic symptoms of the lumbar spine or its multiplicity from an anatomical viewpoint. The first element is the problem of neural tissue. The second element is the bone or the soft tissue existing around the circumference of the neural tissue. The third element is the correlation of the above two. In other words, the neural tissue as content is too large or the adjacent tissue as container is too narrow or else an aberration in the correlation of the aforesaid is involved. Therefore, it is necessary to study those three elements to comprehend the neurologic symptoms of the lumbar spine.