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Your search keyword '"Koinuma, D"' showing total 3 results
Start Over Author "Koinuma, D" Language japanese
3 results on '"Koinuma, D"'

1. [TGF-beta signaling].

Author

Imamura T and Koinuma D

Subjects
Animals, Carrier Proteins physiology, Genes, Tumor Suppressor, Humans, Intracellular Signaling Peptides and Proteins metabolism, Neoplasms genetics, Protein Binding, Proto-Oncogene Proteins metabolism, Signal Transduction genetics, Smad Proteins metabolism, Smad Proteins physiology, Ubiquitin metabolism, Ubiquitin-Protein Ligases physiology, Proteasome Endopeptidase Complex physiology, Signal Transduction physiology, Transforming Growth Factor beta physiology, Ubiquitin physiology
Published
2006

2. [Bone formation and inflammation].

Author

Koinuma D and Imamura T

Subjects
Animals, Bone Morphogenetic Proteins physiology, Core Binding Factor Alpha 1 Subunit, Humans, Neoplasm Proteins physiology, Sp7 Transcription Factor, Transcription Factors physiology, Inflammation physiopathology, Osteogenesis physiology
Abstract

Role of BMP signaling is crucial in the osteoblast differentiation and bone formation. BMP induces expression of Runx2, a master gene for osteogenesis, and cooperates with Runx2 in mature osteoblast to express target genes. These functions are suppressed by TGF-beta-induced Smad7 together with Smurf1 by various mechanisms, including degradation of type I receptor, Smadl/5, and Runx2. Bone remodeling is achieved by "coupling" of osteoblasts and osteoclasts. Although excess maturation and activation of osteoclasts is well described during inflammation, effect of inflammation to the osteoblast function is still unclear. Further exploration in this area thus might lead to discovery of novel therapeutic targets of inflammatory bone diseases.

Published
2005

3. [TGF-beta family (TGF-beta, activin, BMP)].

Author

Koinuma D, Imamura T, and Miyazono K

Subjects
Apoptosis genetics, Cell Differentiation genetics, DNA-Binding Proteins physiology, Fibrosis etiology, Neoplasms etiology, Neurons cytology, Osteoblasts cytology, Proteasome Endopeptidase Complex physiology, Protein Serine-Threonine Kinases physiology, Receptors, Transforming Growth Factor beta physiology, Smad Proteins, Trans-Activators physiology, Transcription, Genetic genetics, Ubiquitin physiology, Activins physiology, Bone Morphogenetic Proteins physiology, Signal Transduction genetics, Transforming Growth Factor beta physiology
Published
2005

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