1. [HLA-mismatched bone marrow transplantation with post-transplant cyclophosphamide for pediatric patients with aplastic anemia].
- Author
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Okamoto K, Osone S, Matsuura A, Asazuma M, Matsuoka T, Kanayama T, Imamura T, and Hosoi H
- Subjects
- Bone Marrow Transplantation, Child, Cyclophosphamide therapeutic use, Humans, Transplantation Conditioning, Anemia, Aplastic therapy, Graft vs Host Disease prevention & control, Hematopoietic Stem Cell Transplantation
- Abstract
Post-transplant cyclophosphamide (PTCy) has improved the efficacy of HLA-mismatched hematopoietic cell transplantation (HCT) by decreasing the risk of graft-versus-host disease (GVHD) and nonrelapse mortality. If an HLA-matched donor is not available, GVHD prophylaxis with PTCy can also be used for HLA-mismatched HCT in patients with pediatric aplastic anemia (AA). We report two cases of pediatric AA that were treated with HLA-mismatched HCT with reduced-intensity conditioning and PTCy. We administered 50 mg/kg/day Cy for GVHD prophylaxis on days 3 and 4, and tacrolimus and mycophenolate mofetil (or methotrexate) were initiated from day 5. In both the cases, the time to engraftment was favorable and GVHD and infection were controllable. PTCy probably allows us to expand donor candidates in pediatric AA when an HLA-matched donor is not available; however, further studies regarding optimal conditioning regimens and late complications are required.
- Published
- 2022
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