1. [A Case of Pemphigus Vulgaris Showing a Local Nose Erosion as the First Clinical Manifestation].
- Author
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Kaneoka A and Sawada Y
- Subjects
- Acantholysis pathology, Aged, Autoantibodies, Desmoglein 1, Desmoglein 3, Humans, Male, Pemphigus diagnosis, Pemphigus etiology
- Abstract
A 73-year-old male noticed a localized nose erosion that we thought was possibly an exacerbation of skin erosion due to the direct influence of friction from wearing a mask. Blood examination revealed a remarkable increase in serum anti-desmoglein-1 and anti-desmoglein-3 antibodies. A skin biopsy showed acantholysis in the epidermal granular layer. Based on the clinical manifestation and laboratory examination, we diagnosed his eruption as anti-desmoglein-1 and anti-desmoglein-3 antibody - positive pemphigus vulgaris. His skin eruption responded well to oral prednisolone and azathioprine and gradually improved. Pemphigus was a candidate as a differential diagnosis in this case, in which the direct mechanical friction from wearing a mask was thought to be an exacerbating factor of skin eruption.
- Published
- 2022
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