1. 凍結細胞への低線量放射線影響を適応応答効果として検出する試み
- Author
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Yatagai, Fumio, Honma, Masamitsu, Ishioka, Noriaki, Omori, Katsunori, Shimazu, Toru, and Suzuki, Hiromi
- Subjects
double-strand break ,血液細胞 ,放射線量 ,国際宇宙ステーション ,adaptation ,適応 ,International Space Station ,DSB repair ,DSB ,放射線影響 ,blood cell ,リンパ芽球腫 ,突然変異 ,adaptive response ,突然変異誘発 ,cosmic ray ,radiation effect ,X線照射 ,X-ray irradiation ,DSN修復 ,enzymes and coenzymes (carbohydrates) ,培養細胞 ,radiation dosage ,cultured cell ,lymphoblastoid ,宇宙線 ,2重鎖開裂 ,mutation ,mutagenesis ,適応応答 - Abstract
DNA (DeoxyriboNucleic Acid) Double-Strand Break (DSB) was introduced by the I-Sce I expression vector, pCBASce. Repair of DSB introduced by the I-SceI expression vector at the tk+ allele in human lymphoblstoid TK6 cell line, TSCE5, was measured by induction of TK-deficient mutants. Similarly we also measured the revertants due to such repair in its compound heterozygote (tk-/-) cell line, TSCER2, which carried an additional point-mutation in exon 5. The former and later measurements reflect the DSB repair efficiency due to DNA Non-Homologous End-Joining (NHEJ) and Homologous Recombination (HR), respectively. The pre-treatment, C-ion-irradiation of frozen cells, TSCE5 and TSCER2 with 50 mGy enhanced DSB repair due to both pathways of NHEJ and HR, 2 to 3-fold. This kind of adaptive response might be observed with the cells recovered from the long preservation under the frozen status in ISS (International Space Station)., 資料番号: AA0063706094
- Published
- 2008