1. DEAE-デキストランーMMAグラフト共重合体をホストとして用い、ゲストのパクリタキセルと成る、超分子複合体:その人工酵素、抗癌メカニズム
- Subjects
endocrine system ,artificial enzyme ,supramolecular complex ,MDR ,cancer cells ,DEAE-dextran-MMA graft copolymer ,paclitxel ,complex mixtures - Abstract
The supramolecular complex by DDMC/PTX which paclitxel(PTX)as guest is included to DEAE-dextran-MMA copolymer(DDMC)as host formed a nano-particle of 50-300 nm size.It was very useful as DDS for anticancer because of a stable polymeric micelle in vivo.MDR(multi-drug resistance)of melanoma cells B16F10 to PTX has been clearly shown in survival maximal curve.However,DDMC/PTX complex showed a superior anti-cancer efficacy following the Michaelis-Menthene kinetic,which may promote to tublin polymerization by allosteric reaction like enzyme reaction.It was also confirmed that the DDMC/PTX complex shows a very superior anti-cancer activity to PTX alone in mouse skin.The MST(median survival time)of DDMC/PTX groups[328 hours(T/C,2.73)]was twice as long as PTX of 176hours(T/C,1.46)(p
- Published
- 2014