1. 微小管の自発的核生成.
- Author
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今井 洋 and 武藤悦子
- Subjects
- *
RATE of nucleation , *ELECTRON microscopy , *MICROTUBULES , *OLIGOMERS , *TUBULINS , *NUCLEATION - Abstract
The structural pathway of spontaneous microtubule nucleation was identified for the first time using recombinant mutant tubulin with a high nucleation rate, rapid flash-negative stain electron microscopy, and kinetic analyses of the size of critical nucleus. The singlestranded tubulin oligomers assembled during the early stage of polymerization had a variety of lengths and curvatures; however, the majority of these oligomers dissociated to tubulin. It was the few straight oligomers exceeding the critical size that underwent lateral interaction, had two-dimensional growth into sheets, and eventually closed into microtubules. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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