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Your search keyword '"lysosomes"' showing total 36 results
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36 results on '"lysosomes"'

2. RILP interagisce con Vps22 un componente di ESCRT-II

Author

PROGIDA C, MALEROD L, STUFFERS S, VENTIMIGLIA G, STENMARK H, BUCCI, Cecilia, Progida, C, Malerod, L, Stuffers, S, Ventimiglia, G, Stenmark, H, and Bucci, Cecilia

Subjects
Multivesicular bodie, endocytosi, lysosomes, Rab7, RILP, endosome
Published
2007

3. Anderson-Fabry's disease: diagnostic problems, therapeutic relevance, and clinical experience in the treatment of the disease with enzyme replacement therapy in nephropathic patients

Author

B, Cianciaruso, A, Pisani, M V, Andreucci, N, Parente, G, Andria, S, Federico, M, Sabbatini, A, Sessa, Cianciaruso, Bruno, Pisani, Antonio, Andreucci, Mv, Parente, N, Andria, Generoso, Federico, Stefano, Sabbatini, Massimo, Sessa, A., Cianciaruso, B, Andria, G, and Federico, S

Subjects
Male, Chromosomes, Human, X, Clinical Trials as Topic, Infant, Kidney Transplantation, Recombinant Proteins, Diagnosis, Differential, Isoenzymes, Treatment Outcome, Italy, Renal Dialysis, alpha-Galactosidase, Fabry Disease, Humans, Kidney Failure, Chronic, Multicenter Studies as Topic, Female, Lysosomes
Abstract

Aim of this study was to confirm the initial results of a clinical trial on the treatment of Fabry's disease carried out in 13 Italian Nephrology Units. Fabry's disease is a rare, X-linked inherited disease, characterized by a-galactosidase (a-GAL) deficiency, a lysosomial enzymatic activity that results in the accumulation of neutral glycosphingolipids in the endothelial cells of the whole body, and causes painful crises, acroparesthesiae, angiokeratomas, corneal and lens dystrophy, and progressive damage to kidneys, heart and central nervous system, as well as potentially leading to death. The present availability of the recombinant form of a-GAL allows us to prevent or stop the long-term complications of this disease. A clinical trial, generously supported by Genzyme, was started on February 2001. In this trial 20 patients affected by Fabry's disease were periodically treated with agalsidase-beta, the commercial form of the enzyme. The initial results of the trial have indicated that the drug is capable of reducing both the number and intensity of painful crises, improving the patient's sensation of well-being, thus suggesting that this therapeutic approach might theoretically increase life expectancy in these patients.

Published
2003

6. [Podocytes: genetics and biology].

Author

Zennaro C, Armelloni S, Li M, Watanabe S, Pignatari C, Ikehata M, Giardino L, Mattinzoli D, Corbelli A, and Rastaldi MP

Subjects
Animals, Cytoskeleton, Humans, Lysosomes, Membrane Proteins physiology, Mitochondria, Nephrotic Syndrome genetics, Podocytes ultrastructure, Nephrotic Syndrome etiology, Podocytes physiology
Abstract

Progresses in podocyte biology have been strictly connected with genetic advances; the identification of genes mutated in familial and sporadic forms of nephrotic syndrome has been followed by functional studies of the encoded proteins, revealing numerous properties of the cell. The molecules uncovered so far belong to three main categories: a) proteins located at the slit diaphragm, the intercellular junction which laterally connects podocyte processes and is responsible for selectivity of the glomerular filter, b) molecules involved in regulation of actin dynamics, which are essential for the maintenance of podocyte structure and function, and c) molecules belonging to intracellular organelles, such as mitochondria and lysosomes, which are central players in podocyte metabolism. Considering the key role of the podocyte in health and disease of the glomerular filter, better knowledge of this cell is a pre-requisite for developing targeted therapies of glomerular diseases.

Published
2015

7. [UNICITY OR PLURALITY OF THE LYSOSOME PARTICLES].

Author

DIANZANI MU

Subjects
Humans, Rats, Acid Phosphatase, Carbon Tetrachloride Poisoning, Chemical and Drug Induced Liver Injury, Cytoplasm, Electrons, Fatty Liver, Hepatitis, Histocytochemistry, Liver cytology, Liver enzymology, Lysosomes, Microscopy, Microscopy, Electron, Research
Published
1964

8. [The lysosomes].

Author

Tonietti G and Accinni L

Subjects
Animals, Humans, In Vitro Techniques, Microscopy, Electron, Lysosomes
Published
1965

12. [Current pathogenetic aspects of acute gout].

Author

Marmont A, Damasio E, Rossi F, and Gori E

Subjects
Acridines, Acute Disease, Adult, Colchicine therapeutic use, Crystallization, Enzyme Activation, Female, Gout drug therapy, Humans, Lysosomes, Male, Microscopy, Fluorescence, Middle Aged, Gout etiology, Uric Acid metabolism
Published
1969

13. [Research on the pathogenetic mechanisms of hemorrhage due to induced venous stasis. V. Further contribution to the study of the behavior of some enzymatic activities of the blood after venous stasis in subjects with positive tourniquet tests. Considerations on the importance of the increase of permeability of the cell membrane and of lysosomes in the pathogenesis of the hemorrhagic phenomenon].

Author

Neri Serneri GG, Franchi F, Paoletti P, Rossi Ferrini PL, and Ignesti C

Subjects
Adult, Aged, Female, Humans, Male, Middle Aged, Tourniquets, Blood Circulation, Blood Vessels, Cell Membrane Permeability, Enzymes blood, Hemorrhage etiology, Ischemia complications, Lysosomes, Vascular Diseases complications
Published
1966

23. [Recent gains on the reactivity of lymphosytes].

Author

Airò R and Astaldi G

Subjects
Anemia, Hemolytic, Autoimmune etiology, Animals, Antigens, Blood Transfusion, Bursa of Fabricius immunology, Cricetinae, Culture Techniques, Immune Tolerance, Immunization, Lymphocytes cytology, Lysosomes, Plasma Cells immunology, Rats, Sheep, Thymidine metabolism, Thymus Gland immunology, Transplantation Immunology, Tritium, gamma-Globulins analysis, Lymphocytes immunology
Published
1967

32. [Hashimoto's thyroiditis: ultrastructural study].

Author

Lambertenghi-Deliliers G, Ranzi T, Pozzoli E, and Litta Modignani R

Subjects
Antibodies, Biopsy, Complement System Proteins, Epithelial Cells, Female, Humans, Lysosomes, Microscopy, Electron, Middle Aged, Radioimmunoassay, Syndrome, Thyroiditis, Autoimmune immunology, Thyroiditis, Autoimmune pathology
Published
1973

36. [Hepatotoxicity of anabolic steroids].

Author

Rozman C, Urbano A, and Galera H

Subjects
Alanine Transaminase blood, Aspartate Aminotransferases blood, Humans, Liver enzymology, Liver pathology, Liver Function Tests, Lysosomes, Methandrostenolone adverse effects, Mitochondria, Liver drug effects, Nandrolone adverse effects, Sulfobromophthalein blood, Time Factors, Anabolic Agents adverse effects, Chemical and Drug Induced Liver Injury etiology, Liver drug effects
Published
1971

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