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Climate change is real, and we, humans, are responsible for it. Its impact is already evident, both on the Earth system (global warming, sea-level rise, sea-ice melting, more intense and frequent extreme weather events such as heat waves and fires) and on people (famines, health issues, migrations, political tensions and conflicts). We need immediate and concrete mitigation actions aiming to reduce greenhouse gases emissions, and adaptation actions to be able to cope with the increasing changing climate. We have to reach zero-net greenhouse gases emissions as soon as possible, by reducing emissions by at least 5% a year, starting from now. Otherwise the climate change impact will become more and more severe: it will induce more injustice, and it will have a major impact on people health. We have the resources and the technologies to deal with it: we must have the courage to change and transform and deal with it. Addressing climate change is not impossible: to the contrary, it is a ‘possible mission’.