48 results on '"Spina V."'
Search Results
2. LA VALUTAZIONE RADIOLOGICA DEL CARICO LESIONALE IN FASE SUBACUTA PREDICE IL RECUPERO FUNZIONALE NEL PAZIENTE CON ESITI DI TRAUMA CRANICO
- Author
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Venturi, Martina, Cecchetti, Luca, Spina, V, Ricciardi, Emiliano, Tomaiuolo, Francesco, and Carboncini, MARIA CHIARA
- Published
- 2016
3. La risonanza magnetica con studio dinamico e sottrazione di immagini nella valutazione della risposta dell'osteosarcoma alla chemioterapia [Dynamic contrast enhanced Magnetic Resonance Imaging Subtraction in evaluating osteosarcoma response to chemotherapy]
- Author
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Torricelli, Pietro, Montanari, N, Spina, V, Manfrini, M, Bertoni, F, Saguatti, G, and Romagnoli, R.
- Published
- 2001
4. Use of the GnRH-agonist (GnRH-A) in gynaecology
- Author
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Ciardo, A, Spina, V, and Aleandri, Vincenzo
- Subjects
Female ,Gonadotropin-Releasing Hormone/analogs & derivatives ,Gonadotropin-Releasing Hormone/pharmacology ,Gonadotropin-Releasing Hormone/therapeutic use - Published
- 1998
5. Pregnancy-related immune tolerance. Maternal-fetal interactions
- Author
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Spina, V, Aleandri, Vincenzo, Pacchiarotti, A, and Salvi, M.
- Subjects
Pregnancy ,Immunology ,Immune Tolerance ,Humans ,Female ,Maternal-Fetal Exchange - Published
- 1998
6. Gravidanza dopo trapianto cardiaco: aspetti fetali
- Author
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Spina, V, Aleandri, Vincenzo, Cantonetti, G, Lambiasi, A, Ciardo, A, and Morini, F.
- Subjects
Feto ,Trapianto cardiaco ,Gravidanza - Published
- 1997
7. CID in Ostetricia
- Author
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Morini, Alberto, Aleandri, Vincenzo, Spina, V, Lambiasi, A, Cantonetti, G, Bonessio, L, and Ciardo, A.
- Subjects
CID in gravidanza ,Emorragia ,Patologie ostetriche ,Gestosi - Published
- 1997
8. PSEUDOTUMORE INFIAMMATORIO DEL MEDIASTINO. DESCRIZIONE DI UN CASO
- Author
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Tazzioli, Giovanni, DE SANTIS, M, Spina, V, and Bevini, M.
- Subjects
granuloma plasmacellulare ,pseudotumore infiammatorio ,mediastino - Published
- 1996
9. An interactive atlas of magnetic resonance anatomy on CD-ROM for Macintosh
- Author
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Montanari, N., Bertolani, M., Romagnoli, R., Spina, V., and Torricelli, P.
- Subjects
foot and elbow ,Computers ,ankle ,educational aid ,Anatomy ,Computers, educational aid ,MRI, ankle, foot and elbow ,MRI - Published
- 1996
10. Magnetic resonance imaging of the brachial plexus: Anatomy and study technique
- Author
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Montanari, N., Spina, V., Torricelli, P., Marongiu, M. C., Bertolani, M., De Santis, M., and Romagnoli, R.
- Subjects
Brachial plexus, anatomy ,Brachial plexus, MRI ,anatomy ,Brachial plexus ,MRI - Published
- 1996
11. La Contraccezione
- Author
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Aleandri, Vincenzo and Spina, V.
- Subjects
Adolescenza ,Contraccezione ,Rapporti sessuali - Published
- 1995
12. The epiphyseal involvement of metaphyseal bone sarcomas in patients with fertile growth plates. A magnetic resonance assessment
- Author
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Spina, V., Torricelli, P., Montanari, N., Manfrini, M., Picci, P., Sangiorgi, L., and Romagnoli, R.
- Published
- 1994
13. Osteosarcoma: Magnetic resonance imaging following preoperative chemotherapy
- Author
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Spina, V., Torricelli, P., Manfrini, M., Picci, P., and Romagnoli, R.
- Subjects
osteosarcoma ,chemotherapy ,osteosarcoma, chemotherapy ,osteosarcoma, MRI ,MRI - Published
- 1993
14. The evolution of estroprogestative contraception: Analysis on the reduction or suppression of side-effects
- Author
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Spina, V., Aleandri, Vincenzo, and Morini, Alberto
- Subjects
Contraccezione estroprogestinica ,Neoplasie mammarie ,Neoplasie della portio ,Riproduzione anomalie ,Effetti metabolici ,Rischi cardiovascolari - Published
- 1992
15. 'La Risonanza Magnetica nello Studio dell'Osteosarcoma'
- Author
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Spina, V, Romagnoli, R, Manfrini, M, Cerofolini, E, Capanna, Rodolfo, Gaiani, L, CALANDRA BUONORA, P, Picci, P, and Campanacci, M.
- Published
- 1991
16. Comparison between 2D and 3D computed tomography evaluation of glenoid bone defect in unilateral anterior gleno-humeral instability.
- Author
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Magarelli N, Milano G, Baudi P, Santagada DA, Righi P, Spina V, Leone A, Amelia R, Fabbriciani C, and Bonomo L
- Subjects
- Adolescent, Adult, Chi-Square Distribution, Confidence Intervals, Female, Humans, Male, Middle Aged, Radiographic Image Interpretation, Computer-Assisted, Humerus diagnostic imaging, Imaging, Three-Dimensional, Joint Instability diagnostic imaging, Shoulder Joint diagnostic imaging, Tomography, X-Ray Computed methods
- Abstract
Purpose: This study evaluated the agreement between 2D and 3D computed tomography (CT) measurements in identifying the size and type of glenoid-bone defect in anterior glenohumeral instability., Materials and Methods: One hundred patients affected by unilateral anterior glenohumeral instability underwent a CT of both shoulders. Images were processed with both 2D [multiplanar reconstruction (MPR)] and 3D [volumerendering (VR)] methods. The area of the missing glenoid was calculated in comparison with the healthy glenoid and expressed as a percentage. Agreement between the two measurements was assessed according to the Bland-Altman method; a 5% mean difference was considered as clinically relevant., Results: Analysis of agreement between MPR and VR measurements of the percentage of missing glenoid showed a mean difference equal to 0.62%±1.96%. Percent agreement between the two measurements in detecting the presence of bone defect was 97% (p<0.0001). Percent agreement between the two measurements in discriminating the type of bone defect was 97% (p<0.0001)., Conclusions: Agreement between 2D (MPR) and 3D (VR) CT measurements to identify the size and type of glenoid-bone defect in anterior glenohumeral instability was so high that the two measurements can be considered interchangeable.
- Published
- 2012
- Full Text
- View/download PDF
17. [Diffuse post-traumatic calcification of the anterior longitudinal ligamentum of cervical and dorsal spine].
- Author
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Manzini CU, Spina V, Mascia MT, Magistro R, Carpenito G, and Ferri C
- Subjects
- Adult, Humans, Male, Time Factors, Tomography, X-Ray Computed, Calcinosis diagnostic imaging, Calcinosis etiology, Cervical Vertebrae diagnostic imaging, Cervical Vertebrae injuries, Ligaments diagnostic imaging, Spondylarthropathies diagnostic imaging, Spondylarthropathies etiology
- Abstract
Among the different conditions causing inflammation and calcification/ossification of the soft tissues of the spinal cord, single or recurrent traumatic events are included. Within the international literature, the involvement of the posterior longitudinal ligament, following spinal cord injuries is frequently reported, especially in the elders. The Authors describe here an uncommon calcification/ossification of the anterior longitudinal ligament occurred after a double traumatic event in a young man, followed clinically and radiologically for a long-term period. On the basis of clinical, laboratory and radiological findings, the differential diagnosis with other possible aetiologies, especially DISH (Diffuse idiopathic skeletal hyperostosis) and ankylosing spondylitis, is discussed.
- Published
- 2004
- Full Text
- View/download PDF
18. [Prenatal diagnosis of congenital diaphragmatic hernia: an update].
- Author
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Spina V, Bagolan P, Nahom A, Trucchi A, Aleandri V, Fabiani C, and Giorlandino C
- Subjects
- Female, Hernia, Diaphragmatic epidemiology, Humans, Pregnancy, Prognosis, Hernia, Diaphragmatic diagnostic imaging, Hernias, Diaphragmatic, Congenital, Ultrasonography, Prenatal
- Abstract
Congenital diaphragmatic hernia (CDH) has an incidence of approximately 1:4000 live births. Most frequently the diaphragmatic defect is a left and posterolateral (Bochdalek) one. Prenatal diagnosis is made at ultrasonography; the relevant sonographic features will be described in the paper. Cystic adenomatoid malformation of the lung (CAML), pulmonary sequestration, bronchogenic cysts, pulmonary hypoplasia/agenesia need to be considered in differential diagnosis. In some cases, diagnosis of CDH is not possible "in utero": in such cases, herniation of abdominal viscera into the thorax takes place presumably just at delivery through a small diaphragmatic defect. CDH may be associated with intrauterine growth retardation (IUGR), chromosomal abnormalities (3%) and/or other malformations (10-50%): such as Central Nervous System, digestive, cardiac and urogenital anomalies. Therefore, search of associated malformations and amniocentesis with analysis of fetal karyotype are mandatory, whenever a CDH is diagnosed. CDH is still at present characterised by a high mortality (reportedly, about 45%). Many prognostic factors have been correlated to postnatal outcome of CDH: some of them are valuable prenatally by ultrasonography. However, the role of sonography in the prediction of neonatal outcome is still controversial: in particular, although many ultrasonographic parameters have been proposed, prenatal evaluation of pulmonary hypoplasia (a crucial factor related to postnatal survival) has not proved to be very accurate so far. Nevertheless, it is undisputable that prenatal diagnosis itself represents a crucial prognostic factor for CDH, since it allows birth of the affected fetuses in 3d level Perinatologic Centres provided with a Neonatal Intensive Care Unit and Neonatal Surgery.
- Published
- 2003
19. [Asthma and pregnancy].
- Author
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Bertelli S, Bartucca B, Bonessio L, Spina V, and Aleandri V
- Subjects
- Administration, Oral, Aerosols, Anti-Asthmatic Agents administration & dosage, Anti-Asthmatic Agents therapeutic use, Female, Humans, Infant, Newborn, Pregnancy, Respiratory Function Tests, Respiratory Therapy, Risk Factors, Asthma diagnosis, Asthma drug therapy, Asthma physiopathology, Pregnancy Complications diagnosis, Pregnancy Complications drug therapy, Pregnancy Complications physiopathology
- Abstract
During pregnancy the asthma has an incidence of 1-4%. In addition to this pathology we find, during pregnancy, an increased incidence of complications both maternal and fetal. These complications, often serious, happen nearly exclusively in patients with severe asthma and/or badly controlled. Therefore, to reduce the risk of beginning of these complications it's necessary to assess correctly the gravity of asthma before becoming pregnant, to make a careful and periodic control of the respiratory function of the patient, to effect a suitable preventive and/or symptomatic pharmacological therapy and to establish specific sanitary-action measures able to prevent the disease becomes acute.
- Published
- 2003
20. [Current clinical features of septic abortion in Western countries. A series of cases observed during 1998 at the 1st and 2nd department of obstetrics and gynecology of the University of Rome La Sapienza].
- Author
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Spina V, Bertelli S, Bartucca B, Bonessio L, and Aleandri V
- Subjects
- Adolescent, Adult, Female, Humans, Italy, Pregnancy, Retrospective Studies, Western World, Abortion, Septic epidemiology
- Abstract
Background: Advances in diagnostic techniques and therapy and the institution of both legislative measures and Centres for the protection of mother-infant health are major factors to which the reduced incidence of septic abortion in should probably be ascribed in Western Countries, where it reaches approximately 10%. The aim of this study was to analyse the current problems related to this pathology in a Western Country, such as Italy., Methods: Cases of septic abortion observed at the I and II Department of Obstetrics and Gynaecology of University of Rome La Sapienza during 1998 were retrospectively analysed., Results: 42 cases of septic abortion were observed. Fever was present in 100 % of cases, genital bleeding in 57 %, abdominal-pelvic pain in 16.7%, genital purulent discharge in one case (2.4%), pain of the fornices at vaginal examination in another (2.4%). Leucocytosis was detected in 21.5% of patients. Disseminated intravascular coagulation (DIC) occurred in one patient (2.4%). No maternal deaths were observed. Antibiotic therapy was carried out in 81% of cases, a uterine curettage in 95.2%., Conclusions: Currently, the possibility of early diagnosis of abortion due to the routine use of ultrasonography and, as a consequence, of early antibiotic therapy, whenever a sepsis is suspected, account for the predominance of mild or even doubtful clinical pictures of this pathology in Western Countries. Nevertheless, severe complications are possible in the case of septic abortion, including septicaemia, septic shock, DIC, renal insufficiency. Thus, a correct and careful attitude of prophylaxis and therapy is required.
- Published
- 2001
21. [Female genital mutilation: FGM patients treated at the "Umberto I" polyclinic of Rome: 1985-1996].
- Author
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Bonessio L, Bartucca B, Bertelli S, Morini F, Aleandri V, and Spina V
- Subjects
- Adult, Female, Humans, Middle Aged, Rome, Circumcision, Female adverse effects, Circumcision, Female statistics & numerical data
- Abstract
The article deals with the medical aspect regarding female genital mutilations (FGM). The cultural origin of this tradition is also considered. Such a practice lies in the partial or complete excision of the external genitalia: it is highly widespread in Central Africa, especially in Ethiopia and Somalia. Currently, approximately 130,000,000 women are involved worldwide. In Italy, it is estimated that about 30,000 women amongst the immigrant population are involved (1). Due to the increasing immigration of women from Countries with FGM tradition, knowledge of the pathologies related to such a practice has become urgently necessary to physicians of western Countries. The aim of this study was to analyze the short-term complications of FGM, which are severe and often even deadly, as well as the long-term ones, which are more likely to be faced in the clinical practice of a western Country physician. In particular, a sample of nine women who had undergone infibulation, amongst the patients admitted at the Departments of Obstetrics and Ginaecology of university of Rome "La Sapienza" during the period 1 January 1985-31 december 1996, has been analyzed. Five out of these women suffered form gynaecological pathologies, whilst four from obstetrical pathologies. Our data on complications associated with FGM are in agreement with those of the world literature and highlight how a more specific expertise is necessary for a correct health care of these women.
- Published
- 2001
22. [Current epidemiologic features of septic abortion].
- Author
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Spina V, Bertelli S, Bartucca B, Bonessio L, and Aleandri V
- Subjects
- Abortion, Septic diagnosis, Adolescent, Adult, Age Factors, Amniocentesis adverse effects, Developing Countries, Diabetes Complications, Female, Fetal Membranes, Premature Rupture, HIV Seropositivity complications, Humans, Italy epidemiology, Parity, Pregnancy, Retrospective Studies, Risk Factors, Abortion, Septic epidemiology
- Abstract
Background: This article deals with the current epidemiological features of septic abortion., Methods: Forty-two of 431 abortions (9,74%) were diagnosed as septic abortions during 1998 at the I and II Institute of Obstetrics and Gynecology, University of Rome La Sapienza , and are retrospectively analyzed., Results: Thirty-four women (81%) came from an EEC country, whereas 8 (19%) from a developing country. Their mean age was 31,4 years (range: 18-43 years). Eighteen patients (43%) were nulliparous; 24 (57%) multiparous; 14 (33%) had previous abortions, none had previous septic abortions. Among risk factors, premature rupture of membranes was found in 5 cases (12%); whereas amniocentesis, HIV positivity, diabetes, positive urine culture and illegal pregnancy termination procedures were found in 5 further cases. No risk factors were found in 76% of patients., Conclusions: It is observed that, due to medical-scientific advances, previously unknown risk factors have emerged during the last three decades in Western Countries, such as invasive procedures of prenatal diagnosis, IUD contraception and AIDS immunodepression. However, other previously frequent risk factors, such as sepsis from illegal abortion, may emerge again in Countries where abortion is legal (such as Italy), due to massive immigration of clandestine women from developing Countries.
- Published
- 2001
23. [Etiology and epidemiology of extrauterine pregnancy].
- Author
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Caputo S, Bonessio L, Ciardo A, Salvi M, and Spina V
- Subjects
- Adolescent, Adult, Female, Humans, Pregnancy, Retrospective Studies, Pregnancy, Ectopic epidemiology, Pregnancy, Ectopic etiology
- Abstract
In the last years, ectopic pregnancy has become a frequent problem, especially in the industrialized countries. Women aged 30-40 years are mostly affected. Infact, in this ten-years period, more and more women feel the desire of pregnancy at ripe age, first of all because of their job. This study shows 136 cases of extrauterine pregnancy, observed at our hospital, I and II Institute of Obstetric and Gynecological Clinic of "Policlinico Umberto I" in Rome from January 1997 to December 1999. The object of this analysis is to determine the characteristics and ethiologic factors of this pathology.
- Published
- 2000
24. [Female genital mutilation and legislation].
- Author
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Bonessio L, Bartucca B, Bertelli S, Morini F, and Spina V
- Subjects
- Africa, Europe, Female, Humans, Italy, Legislation, Medical, Circumcision, Female statistics & numerical data, Women's Health
- Abstract
This article deals with the legal aspect concerning female genital mutilations (FGM). Such a practice (a partial excision of the external genitalia) is highly widespread in Central Africa, especially in Ethiopia and Somalia, and currently involves approximately 130,000,000 women worldwide and, in Italy, about 30,000 women amongst the immigrant population. Since 1982 the World Health Organization (WHO), which condemns such a practice as injurious to women's rights and health, proposed that laws and professional codes prohibit it in all countries. Legislation, although insufficient as a sole measure, is considered indispensable for the elimination of FMG. Since a long time some western countries (Sweden, Great Britain, Belgium and Norway), involved by immigration from countries with FGM tradition, legislated with regard to FGM. In Italy, a specific law does not exist; however, FGM are not allowed by the article 5 of the Civil Code. Nevertheless, recently, several cases of mutilations took place: this led some members of the Parliament to introduce a bill in order to specifically forbid FGM. The authors believe that legislation could effectively support the job of prevention and education, which physicians may carry out in order to save little girls from the risk of familial tradition of genital mutilations.
- Published
- 2000
25. [Immune tolerance in pregnancy. Maternal-fetal interactions].
- Author
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Spina V, Aleandri V, Pacchiarotti A, and Salvi M
- Subjects
- Female, Humans, Immune Tolerance, Maternal-Fetal Exchange immunology, Pregnancy immunology
- Abstract
The conceptus may be considered as a sort of semi-allogenic graft for the maternal organism, since it shares a half of genomic complement with the father. Nevertheless, its rejection does not take place physiologically during a pregnancy. The mechanisms resulting in the maternal immune tolerance versus the conceptus are not yet completely clarified. Such mechanisms are probably multiple and interacting with each other. In animal and in vitro studies provide evidence suggesting that the following factors are important in producing the maternal immune tolerance: the anatomical position of the fetus; the absence of expression of the class I and II Major Histocompatibility Complex (MHC) molecules in trophoblast tissues; the activity of blocking antibodies; a modification of the immune response; the fetal-placental production of immunosuppressive hormones and substances. Amongst pregnancy-related changes in the immune response, a reduced Natural Killer (NK) cell activity and an increased synthesis of Th2 cytokines (which inhibit the cell-mediated immunity) with an altered Th1/Th2 balance appear to be remarkably important. With regard to fetal-placental hormones, progesterone seems to exert an important immunosuppressive influence mediated by the protein named "Progesterone Induced Blocking Factor" (PIBF). Nevertheless, the real contribution of each of the above mentioned mechanisms still remains to be elucidated in humans.
- Published
- 1998
26. [Contraception after heart transplantation].
- Author
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Spina V, Aleandri V, and Salvi M
- Subjects
- Contraceptives, Oral, Synthetic administration & dosage, Ethinyl Estradiol administration & dosage, Female, Humans, Norpregnenes administration & dosage, Pregnancy, Pregnancy Outcome, Progesterone administration & dosage, Risk Factors, Contraceptives, Oral, Hormonal, Heart Transplantation, Pregnancy Complications, Cardiovascular etiology
- Abstract
It was observed that fertility and menstrual function in heart-transplanted women, impaired before the operation, become normal with a new heart. The restoration of reproductive function is also confirmed by many cases of pregnancy in heart-transplant recipients, reported in the literature. Twenty-four cases were published worldwide up to 1997, out of which eighteen had a positive result. Also a case personally treated was successful. The outcome of a pregnancy after heart transplantation is, then, generally positive. Nevertheless, such a pregnancy involves important maternal and fetal risks. Thus, the gynecologist has to provide correct information about both such risks and the most suitable contraceptive methods, for these patients. Oral contraceptives are very effective and, in the new low-dose formulations, free from serious adverse effects. No adverse effects have been observed in our patient, who represents the only case, reported in the literature, in which an estroprogestinic contraception was utilized before a pregnancy. In conclusion, during an oral contraception or after a tubal sterilization, pregnancy is really unlikely to occur. Thus, when the couple either has completed the familial nucleus or does not desire offspring, a doubt is at least justified as to whether these safer methods of contraception are advisable in such women.
- Published
- 1998
27. [Use of GnGH (GnRH-A) in gynecology].
- Author
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Ciardo A, Spina V, and Aleandri V
- Subjects
- Female, Gonadotropin-Releasing Hormone pharmacology, Humans, Male, Prostatic Neoplasms drug therapy, Gonadotropin-Releasing Hormone analogs & derivatives, Gonadotropin-Releasing Hormone therapeutic use, Leiomyoma drug therapy, Uterine Neoplasms drug therapy
- Abstract
GnRH-agonist therapy is used in the management of many gynaecological pathologies: uterine fibroids, endometriosis, ovarian cystic pathology, breast cancer, dysfunctional uterine bleeding and, in males, prostatic cancer. In the case of uterine fibroids, this therapy can be used as a pre-treatment before conservative or demolitive surgery or as an alternative to hysterectomy. At the Centre for Therapy of Uterine Pathologies (I Institute of Obstetrics and Gynaecology of the University of Rome "La Sapienza") the use of Gn-RH-A therapy in uterine fibroids has been investigated and results consistent with those of many other groups of study have been obtained. The two most important results are: 1. the decrease of both the myoma's size and the uterine volume; 2. the block of menometrorrhagiae symptoms, with improvement of the haematic crasis and possibility to convert a demolitive surgery to a conservative surgery. GnRH-agonists can represent a definitive treatment for patients with symptomatic uterine fibroids and in perimenopausal age.
- Published
- 1998
28. [The role of the pineal body in the endocrine control of puberty].
- Author
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Aleandri V, Spina V, and Ciardo A
- Subjects
- Adolescent, Animals, Female, Humans, Male, Melatonin physiology, Sexual Maturation physiology, Pineal Gland physiology, Puberty physiology
- Abstract
The pineal gland plays an important role in reproductive endocrinology. The epiphysis regulates seasonal variations in reproductive function of seasonally breeding animals. In humans, even if they are not seasonal breeders, the role of the pineal in reproductive endocrinology seems to be important as well. It appears to be of particular importance the endocrine control of the gland on pubertal sexual maturation. Even if not all researchers agree, several data suggest that elevated melatonin levels-characteristic of prepubertal age-keep the hypothalamic-pituitary-gonadal axis in quiescence: thus, an inhibitory effect on pubertal development is exerted. Subsequently, the decreasing serum melatonin with advancing age would result in activation of the hypothalamic pulsatile secretion of GnRH- and therefore of the reproductive axis-with consequent onset of pubertal phenomena. The production rate of melatonin does not change with age and no growth in pineal size from 1 to 15 years of age has been demonstrated by nuclear magnetic resonance (NMR) studies. Therefore the decrease of serum melatonin concentrations has been proposed to be due to the increase in body mass or, according to another hypothesis, to be also temporally linked to sexual maturation. Furthermore, recently, it has been suggested in rats that the pineal influences not only the pubertal sexual maturation, but even the gonadal and genital development and function of offspring, already during intrauterine life. Investigations are needed to evaluate this hypothesis in humans.
- Published
- 1997
29. [Inflammatory mediastinal pseudotumor. Report of a case].
- Author
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Drago A, De Santis M, Spina V, Tazzioli G, and Bevini M
- Subjects
- Humans, Male, Middle Aged, Granuloma, Plasma Cell diagnosis, Mediastinal Diseases diagnosis
- Published
- 1996
30. [Interactive atlas with magnetic resonance on CD-ROM for Macintosh].
- Author
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Montanari N, Bertolani M, Romagnoli R, Spina V, and Torricelli P
- Subjects
- Microcomputers, Anatomy education, Anatomy, Artistic, Audiovisual Aids, CD-ROM, Magnetic Resonance Imaging, Medical Illustration
- Abstract
Computer assisted education in radiology has been increasingly used during the past ten years and now complements traditional learning resources. Magnetic Resonance Imaging (MRI) of musculoskeletal anatomy, and particularly of joints, lends itself naturally to learning modules on computer. This paper describes the design, development and use of an interactive computer assisted teaching module of MR joint anatomy on CD-ROM for Macintosh: to date, we have used this atlas for ankle and elbow anatomy. The atlas is divided into three main sections: MR anatomy, traditional anatomy and a quiz. On each MR image, any anatomical detail can be identified clicking on it with the mouse. Buttons allow to visualize cross-reference points and to go directly on the desired image. If the student wants to look at anatomical drawings of the last identified structure, a button retrieves all the cards in the traditional anatomy section containing that structure. Finally, the student can make his own self-assessment, verifying his learning immediately with the exam mode: the software makes a random selection of 10 MR images where an anatomical structure must be indicated: if the answer is wrong, the software gives the right one and shows the misinterpreted structure. Then, the student is given a total score for his performance. The computer assisted teaching modules present some advantages: the images can be viewed in a given sequence (like traditional learning resources) or in any self-paced, customized way; this possibility, together with the friendly interface of Macintosh computers could make learning more active and pleasant.
- Published
- 1996
31. [Intrahepatic cholestasis in pregnancy].
- Author
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Bonessio L, Ciardo A, Spina V, and Morini A
- Subjects
- Adult, Female, Humans, Pregnancy, Cholestasis, Intrahepatic diagnosis, Pregnancy Complications diagnosis
- Abstract
Intrahepatic cholestasis of pregnancy (ICP) is a syndrome usually manifesting during the third trimester of pregnancy and disappearing after delivery. Multiple factors seem to be involved in pathogenesis of the syndrome; however, ICP appears to take place in women congenitally hypersensitive to estrogens. Typical is pruritus, which may be followed by jaundice and associated with other less common symptoms. The biochemical parameters are characteristically altered: an increase in the levels of aminotransferases (AST, ALT), total bile acids and alkaline phosphatase is observed; while serum GGT are normal. Maternal prognosis is benign. By contrast, a higher risk of acute fetal distress and prematurity has been reported. Various drugs are used in the treatment of ICP. We present the case of a patient treated with S-adenosyl-L-methionine (SaMe). SaMe therapy has proved to be effective in improving the altered biochemical parameters, whose normalization was obtained before delivery.
- Published
- 1996
32. [Magnetic resonance of the brachial plexus: anatomy and study technique].
- Author
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Montanari N, Spina V, Torricelli P, Marongiu MC, Bertolani M, De Santis M, and Romagnoli R
- Subjects
- Humans, Brachial Plexus anatomy & histology, Magnetic Resonance Imaging methods
- Abstract
Brachial plexopathies are a common diagnostic problem: conventional imaging techniques can be useful in the detection of associated conditions (Pancoast tumors, first rib or clavicle fractures, etc.) but they cannot visualize brachial plexus structures directly. Also Computed Tomography (CT) is limited in the study of the retroclavicular region because of the artifacts due to the presence of the humeral heads in the slice. CT myelography exhibits very high accuracy in posttraumatic brachial plexopathies but fails to reveal the postganglionic plexus. In contrast, Magnetic Resonance Imaging (MRI) allows the direct detection of the brachial plexus, from spine to axilla, thanks to its multiplanarity and high contrast resolution. However, MR images are so rich in anatomical details (particularly on the oblique planes) that sometimes they become very difficult to interpret. To better define the anatomical relationships of the brachial plexus and to assess the best planes to study its different portions, 9 healthy volunteers were examined with MRI and MR images were compared with anatomical drawings and frozen cadaver sections. MRI depicts the brachial plexus from its origin to the axilla, but none of the investigated planes is sufficient, alone, to study the whole plexus adequately. The paraganglionic portion is clearly depicted on oblique sagittal images, while coronal and sagittal images are more useful for primary trunks and spinal nerves; the distal portion is perfectly visualized on sagittal images. Thus, we conclude that different examination protocols are necessary for every specific plexus portion, which means that brachial plexus MRI must be performed to try to solve a specific question by the orthopedic surgeon or the clinician.
- Published
- 1996
33. [Fetal lesions due to the bistoury during cesarean section: a study of 58 cases. The 5-year case records of 3117 cesarean sections at the Institutes of Clinical Obstetrics and Gynecology of the University of Rome La Sapienza].
- Author
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Morini A, Cantonetti G, Spina V, and Bonessio L
- Subjects
- Birth Injuries epidemiology, Cesarean Section instrumentation, Cesarean Section statistics & numerical data, Chi-Square Distribution, Emergencies, Female, Humans, Incidence, Infant, Newborn, Pregnancy, Rome epidemiology, Wounds, Penetrating epidemiology, Birth Injuries etiology, Cesarean Section adverse effects, Prenatal Injuries, Wounds, Penetrating etiology
- Abstract
In the present article the authors have carried out a statistical investigation on data relative to the caesarean sections performed in the Departments of Obstetrics and Gynaecology of the University of Rome "La Sapienza" since 1986 to 1990. Particular object of this study is to evaluate data regarding fetal bistoury lesions incidentally caused while performing the incision of the uterine wall during a caesarean section. To our knowledge, this topic has never been taken into account by the world's literature, nevertheless it is important also for its legal and insurance implications. Throughout the mentioned period 13787 deliveries occurred, 3117 of which were caesarean sections: this is equal to a frequency of 22.6%, with an increase rate of 37.5% during the whole 5 years time. 58 cases of fetal bistoury lesions have been found to occur since 1986 to 1990: this equal to 1.8% of all the performed caesarean sections. Even if their gravity was usually scarce, and only 7 cases needed a specific treatment, 25.8% of these lesions involved areas such as forehead, cheek bone, cheek, mostly related to possible aesthetic damages with their connected legal consequences. In order to evaluate what factors can contribute to the occurrence of these lesions and taking account of the large number of factors that may be involved (such as conditions at which the operation is performed, skill and experience of the surgeon etc.), the authors focus their attention to those which, for their clinical significance and possibility of detection, suit more than others such a statistical investigation.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1995
34. [The epiphyseal involvement of metaphyseal bone sarcomas in patients with fertile growth plates. A magnetic resonance assessment].
- Author
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Spina V, Torricelli P, Montanari N, Manfrini M, Picci P, Sangiorgi L, and Romagnoli R
- Subjects
- Adolescent, Arm, Child, Contrast Media, Diaphyses pathology, Epiphyses pathology, Female, Femoral Neoplasms diagnosis, Gadolinium, Gadolinium DTPA, Humans, Leg, Male, Organometallic Compounds, Pentetic Acid analogs & derivatives, Sensitivity and Specificity, Bone Neoplasms diagnosis, Growth Plate pathology, Magnetic Resonance Imaging instrumentation, Magnetic Resonance Imaging methods, Sarcoma diagnosis
- Abstract
The growth plate is thought to be capable of limiting tumor spread. To assess the presence and extent of epiphyseal involvement in bone tumors, the plain radiographs and the MR images of 41 patients with metaphyseal sarcoma and radiographically apparent growth plate were studied. The results were compared with surgical, microscopic and histologic findings. Histology demonstrated that in 3 patients the tumor did not reach the growth plate, in 25 the epiphysis was involved while in 13 cases the tumor reached the physis but did not spread to the epiphysis. In the latter group of patients, histology demonstrated a microinfiltration of the physis in 5 cases. Radiography and MR sensitivities were 77.2% and 100%, respectively, while specificity was 94% for both methods. Histology showed that the epiphysis was involved in 25/41 cases (61%) and the growth plate in 30/41 (73%). Our results show that the growth plate does not usually act as a barrier against tumor spread and that MRI is the diagnostic tool of choice in the assessment of epiphyseal spread in metaphyseal tumors even though it cannot detect growth plate microinfiltrations.
- Published
- 1994
35. [Clinical evaluation of DHEA-S plasma levels and possible therapeutic value of the hormone in the third trimester].
- Author
-
Scarpellini L, Scarpellini F, and Spina V
- Subjects
- Adult, Dehydroepiandrosterone therapeutic use, Estriol blood, Female, Humans, Longitudinal Studies, Parity, Pregnancy, Pregnancy Trimester, Third, Progesterone blood, Dehydroepiandrosterone blood, Uterine Cervical Incompetence drug therapy
- Abstract
Three groups of women were studied. The first included women without obstetric or systemic pathology; in these, plasma concentrations of progesterone, E, and DHEA-S were assayed at 30-40 weeks of pregnancy. The second group comprised women after physiological first delivery at term, and in these the plasma levels of the same hormones were assessed. In the third group, comprising women at 38 weeks of pregnancy with unripened cervix and DHEA-S plasma levels that were by 1-2 weeks below those of women with ripened cervix of the same gestational age, the effect of repeated perfusion with DHEA-S was examined.
- Published
- 1993
36. [The pharmacological options for an immediate intervention in threatened premature labor].
- Author
-
Scarpellini L, Scarpellini F, and Spina V
- Subjects
- Adolescent, Adult, Butylscopolammonium Bromide administration & dosage, Drug Evaluation, Drug Therapy, Combination, Female, Humans, Ketoprofen administration & dosage, Parity, Pregnancy, Pregnancy Trimester, Third, Ritodrine administration & dosage, Obstetric Labor, Premature drug therapy
- Abstract
The following preparations, with different mechanism of action, have been comparatively tested for induction of immediate tocolysis in case of threatened preterm labour: Hyoscine butylbromide, ritodrine, ketoprofen and the association of ritodrine with ketoprofen. Hyoscine butylbromide was found to be very easy to handle, but its myolytic effect is modest. Ritodrine and ketoprofen have shown a high and quantitatively similar tocolytic power. But even better results have been achieved with the association of ritodrine with ketoprofen which has shown a total myolytic effect. The authors suggest some hypotheses concerning the mechanism of action of these drugs, and some precautions for their correct clinical use.
- Published
- 1993
37. [Osteosarcoma: magnetic resonance imaging of the effects of preoperative chemotherapy].
- Author
-
Spina V, Torricelli P, Manfrini M, Picci P, and Romagnoli R
- Subjects
- Adolescent, Adult, Bone Neoplasms surgery, Child, Combined Modality Therapy, Female, Humans, Male, Neoplasm Invasiveness, Osteosarcoma surgery, Preoperative Care, Bone Neoplasms diagnosis, Bone Neoplasms drug therapy, Magnetic Resonance Imaging, Osteosarcoma diagnosis, Osteosarcoma drug therapy
- Abstract
The effects of preoperative chemotherapy for osteosarcoma of the extremities were investigated with MR imaging. Forty-six patients affected with high-grade osteosarcomas of the extremities underwent MRI before and after two cycles of preoperative chemotherapy. At the end of treatment all tumors were resected and the rate of tumor necrosis was assessed on histologic sections. The MR images obtained before and after treatment were compared. Decreased tumor size, perilesional intramedullary edema and more marked lesion outline correlated well with positive histologic response to preoperative chemotherapy. Soft tissue edema and joint effusion did not change significantly and no clear correlation with histologic response was observed. Decreased signal intensity on T2-weighted images is likely to indicate response to chemotherapy. Likewise, poor response correlated with unchanged/increased signal intensity. Therefore, MRI appears a useful means to evaluate chemotherapy-induced changes in osteosarcomas of the extremities.
- Published
- 1993
38. [Echography in diseases of the rotator cuff].
- Author
-
D'Alimonte P, Spina V, and Calandra Buonaura P
- Subjects
- Adult, Aged, False Negative Reactions, False Positive Reactions, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Muscular Diseases diagnostic imaging, Predictive Value of Tests, Radiography, Sensitivity and Specificity, Ultrasonography, Rotator Cuff diagnostic imaging
- Abstract
The diagnostic accuracy of shoulder US was investigated in 69 patients with a "painful shoulder" and the results compared with those of MR imaging. In our experience, US exhibited 95% sensitivity, 69% specificity, 83% positive predictive value, 90% negative predictive value and 85% accuracy. The analysis of the single US patterns proved the difficult distinction of small tears from focal tears, whereas complete ruptures were always easy to identify. In summary, all cases of rotator cuff degeneration or tear were always detected but not always correctly identified. False negatives on US included inflammatory processes of cuff structures but never ruptures or degenerations. Therefore, in our diagnostic protocol, US appeared to be a valuable screening method in the exclusion of rotator cuff injuries; other imaging techniques--i.e., arthrography, MR imaging, arthroscopy--were employed only in questionable/positive cases on US.
- Published
- 1993
39. [Spin-echo anatomy of the larynx with magnetic resonance at 1.5 T].
- Author
-
Bertolani M, Calandra Buonaura P, Spina V, D'Alimonte P, Romani U, Criscuolo M, and Romagnoli R
- Subjects
- Contrast Media, Gadolinium DTPA, Humans, Organometallic Compounds, Pentetic Acid, Larynx anatomy & histology, Magnetic Resonance Imaging methods
- Abstract
The larynges of 8 healthy and informed volunteers were studied with a superconductive MR unit at 1.5 T together with those of 10 patients with extralaryngeal pathologic conditions. The study was performed with round surface coils (5") and with dedicated sellar coils in the anterior neck. Slices were 5 mm thick, and acquired on the coronal, axial, and sagittal planes, with T1-weighting; axial scans were repeated in the same locations with double echoes, with proton-density and T2-weighting. Five patients underwent additional scans after Gd-DTPA. The larynx of a semi-frozen cadaver was examined with sellar surface coils, on similar scanning planes and with similar pulse sequences to those described above; the larynx was removed, investigated with mammographic technique, and subsequently analyzed with thin CT slices and a high-resolution reconstruction algorithm for the study of laryngeal cartilage. Axial anatomical sections were then compared with MR and CT scans, and the anatomical structures were recognized on the triplanar MR scans of a volunteer's larynx. Besides MR anatomy of supporting laryngeal structures, the authors describe in detail the muscles, plicae, spaces and cavities which can be identified on the various planes, together with the changes in signal after Gd-DTPA.
- Published
- 1991
40. [Magnetic resonance for the study of osteosarcoma].
- Author
-
Spina V, Romagnoli R, Manfrini M, Cerofolini E, Capanna R, Gaiani L, Calandra Buonaura P, Picci P, and Campanacci M
- Subjects
- Adolescent, Adult, Arm, Bone Neoplasms diagnosis, Child, Female, Humans, Leg, Male, Neoplasm Staging, Osteosarcoma diagnosis, Preoperative Care, Bone Neoplasms pathology, Magnetic Resonance Imaging, Osteosarcoma pathology
- Abstract
The authors report their experience with MR imaging in the study of osteosarcoma. Two main elements were evaluated: signal characteristics and loco-regional staging. Seventy-one patients were studied: 65 of them had central long-bone osteosarcoma, and 6 had telangiectatic long-bone osteosarcoma. T1- and T2-weighted spin-echo sequences were employed and all cases were scanned on 3 planes (sagittal, coronal, and axial). In 28 patients MR imaging was performed both before and after preoperative chemotherapy. The obtained data were compared to surgical and pathological findings. With the exception of the typical signal patterns of quite-osteoblastic osteosarcoma (which presents with low signal on both T1- and T2-weighted sequences), no particular signal features were observed which could help distinguish the different types of osteosarcoma. MR imaging is the method of choice in loco-regional staging for, in our series, it allowed a rational and adequate surgical planning. For this purpose, at least a longitudinal T1- and an axial T2-weighted images are required.
- Published
- 1991
41. [Chronic recurrent multifocal osteomyelitis. Clinico-radiological considerations].
- Author
-
Spina V, Mussini C, Mascia MT, Baldini A, and Cerofolini E
- Subjects
- Adolescent, Chronic Disease, Female, Foot diagnostic imaging, Humans, Knee diagnostic imaging, Osteomyelitis diagnosis, Pelvis diagnostic imaging, Radiography, Radionuclide Imaging, Recurrence, Ribs diagnostic imaging, Osteomyelitis diagnostic imaging
- Published
- 1989
42. [1.5 T MR in the diagnosis of parotid masses: comparison with ultrasonography].
- Author
-
D'Alimonte P, Cerofolini E, Leoni A, Miceli F, Spina V, Romani U, and Romagnoli R
- Subjects
- Adult, Aged, Cysts diagnosis, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Salivary Gland Diseases diagnosis, Sialadenitis diagnosis, Adenocarcinoma diagnosis, Adenoma diagnosis, Lymphoma, Non-Hodgkin diagnosis, Magnetic Resonance Imaging, Parotid Neoplasms diagnosis, Ultrasonography
- Abstract
Twenty-two patients who presented with laterocervical retromandibular enlargement were examined with both US and MR imaging to assess the intrinsic/extrinsic relationship of the mass to the parotid gland, the involvement of the facial nerve and adjacent structures, as well as the nature of the mass. Both US and MR imaging proved to be poorly specific in the characterization of the inflammatory lesions. Within the mass, both methods revealed high sensitivity (100%) in identifying the lesions, even very small ones. MR imaging allowed the lesion to be accurately located, the facial nerve to be identified, and its possible infiltration to be evaluated, with higher reliability than US, thanks to its higher contrast resolution and to its multiplanarity. Neither US nor MR imaging allowed the benign/malignant nature of the lesion to be assessed. On the basis of their experience, the authors suggest the use of T2-weighted MR sequences, with long TR and TE, to differentiate pleomorphic adenomas from other histotypes, after US assessment of the solid nature of parotid masses.
- Published
- 1989
43. [Rotator cuff lesions: evaluation with RM and US].
- Author
-
Leoni A, Cerofolini E, Bertolani M, Spina V, Calandra Buonaura P, and Romagnoli R
- Subjects
- Arthrography, Diagnosis, Differential, Humans, Shoulder Injuries, Magnetic Resonance Imaging, Shoulder Joint, Ultrasonography
- Abstract
Physical and instrumental examination of the patients with an "aching shoulder" is often difficult and a positive out-come of surgical treatment may be impaired by the late diagnosis of long-standing rotator cuff lesions causing tendon adhesions and muscle atrophy. The authors report the results obtained in 25 selected patients with an aching shoulder examined with arthrography, real-time ultrasound (US) with a 5 MHz linear probe, and high-field (1.5 T) Magnetic Resonance (MR) imaging. Arthrography was able to demonstrate a cuff tear in 14/25 cases; US detected signs of tear in 14/25 (1 false negative); MR imaging showed a cuff lesion in 16/25 patients, and in one case allowed a partial cuff tear to be demonstrated, which had not been visualized with arthrography. MR imaging could also demonstrate other signs of periarticular pathologies (tendinitis, longhead of biceps inflammation, and bursitis) that may represent the early stages of the inflammatory-degenerative process underlying most of cuff lesions. The high diagnostic accuracy of US (95%) is stressed in the detection of cuff tears, in patients with an aching shoulder; as for questionable cases at US, MR imaging is indicated as a valid alternative to arthrography, which is more invasive and less accepted by the patients.
- Published
- 1989
44. [1.5-T MR of the knee: the correlations with arthroscopy].
- Author
-
Cerofolini E, Spina V, Miceli F, D'Alimonte P, Leoni A, and Romagnoli R
- Subjects
- Adolescent, Adult, Chronic Disease, Diagnostic Errors, Evaluation Studies as Topic, Female, Humans, Knee Injuries diagnosis, Male, Menisci, Tibial pathology, Middle Aged, Arthroscopy, Knee Joint pathology, Magnetic Resonance Imaging methods
- Abstract
The authors report their experience of knee articular pathologies studied with MR imaging. Forty patients (36 with and 4 without articular trauma) were examined with both MR imaging and arthroscopy. Arthroscopic findings were correlated with MR results in order to evaluate the accuracy of the latter in detecting meniscal tears. MR images were obtained with a 1.5 T unit and a transmit-receiver surface coil. Spin-echo sequences and, occasionally, fast-scan sequences were used both in the coronal and in the sagittal planes. High resolution MR imaging clearly depicted knee anatomy. As far as meniscal lesions were concerned, the authors employed a grading system to classify intrameniscal signals, as proposed by Lotysch. The preliminary results are encouraging and suggest the use of MR imaging as the first imaging modality for use in knee pathology before arthroscopy is performed.
- Published
- 1989
45. [Basic principles of endodontic operative technique].
- Author
-
Borsotti GF, Garberoglio R, Mantero F, Pecchioni A, and Spina V
- Subjects
- Root Canal Therapy methods
- Published
- 1976
46. [Computed axial tomography and radiculography in the diagnosis of disk hernia: comparative study of 102 surgically treated cases].
- Author
-
Luppino T, Salsi A, Spina V, Fiocchi R, and Stefanini T
- Subjects
- Adult, Female, Humans, Intervertebral Disc Displacement surgery, Male, Middle Aged, Intervertebral Disc Displacement diagnostic imaging, Myelography, Spinal Nerve Roots diagnostic imaging, Tomography, X-Ray Computed
- Published
- 1987
47. [Ackerman's technic of apicoectomy].
- Author
-
Spina V and Barbato U
- Subjects
- Humans, Methods, Apicoectomy
- Published
- 1970
48. [Round table. Root canal therapy].
- Author
-
Castagnola L, Borsotti G, Duillo S, Garberoglio R, Mantero F, Pecchioni A, and Spina V
- Subjects
- Root Canal Therapy
- Published
- 1973
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