Unlabelled: The ISP (Safe Insertion of PICCs) protocol: a bundle of 8 recommendations to minimize the complications related to the peripherally inserted central venous catheters (PICC)., Introduction: The insertion of a peripherally inserted central venous catheter (PICC) is not without risks., Aim: The Italian Group for the Study of Long-Term Central Venous Access Devices (GAVeCeLT) has developed a protocol (SIP: Safe Implantation of PICCs) with the aim of minimizing the risks which may be associated with the placement of PICCs., Methods: The protocol is based on recommendations available in the literature and on the main clinical practice guidelines., Results: The SIP protocol, a bundle of evidence-based recommendations, it is is easy to use, inexpensive, and cost-effective., Conclusions: If routinely used and carefully inplemented, it greatly reduces complications such as failure of venipuncture, accidental arterial puncture, damage of median nerve, infection and catheter related venous thrombosis.