Main purposes of our study were to explore: a) the relationships between massive use of Social Networks sites (SNs) in adolescence, school burnout levels and friendship quality; b) gender differences in massive and problematic use of SNs. 110 Italian high school students (M=69,9%) aged 15-17 years participated in the study. Students were asked to complete self-report questionnaires: an ad-hoc scale for investigating SNs use, The Generalized Pathological Internet Use Scale-2 (GPIUS-2; Caplan, 2010), The Parent and Peer attachment inventory for Friendship Quality (Armsden Greenberg, 1987), The School Burnout Inventory (SBI; Samlela-Aro et al., 2009). Results showed positive relationships between massive SNs use and friendship quality (r = .30, p .01); compulsive SNs (GPIUS-2) use and school burnout total score (r = .25, p .01); massive SNs use and female gender (r = .17, p .05), and finally a positive relationship between SNs use for mood regulation and school burnout total score (r = .20, p .05). Moreover, significant difference emerged between females and males in SNs massive use, with higher levels reported by females (M= 23.55, DS= 3.614) in comparison to males (M=21.89, DS=4.261); t(138)= -2.13, p = .035.Overall, this study highlights different dimensions that could influence SNs massive and problematic use in adolescence, specifically school burnout and friendship quality. Structuring interventions in order to promote socio-relational skills among peers and to prevent school-related burnout could prevent problematic use of SNs in adolescence.