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36 results on '"Sacerdote AS"'

3. Effects of nimesulide on pain and on synovial fluid concentrations of sp, il-6, and il-8 in patients with knee osteoarthritis: comparison with celecoxib

Author

Mauro Bianchi, Paola Sacerdote, Silvia Franchi, Paolo Ferrario, Patrizia Balzarini, and Marco Broggini

Subjects
Knee osteoarthritis, interleukin-6, nimesulide, pain, substance P, Anesthesiology, RD78.3-87.3, Therapeutics. Pharmacology, RM1-950
Abstract

We compared the effects of two NSAIDs, nimesulide (100 mg twice a day) and celecoxib (200 mg once a day), on pain and synovial fluid concentrations of inflammatory pain mediators in twenty patients with knee OA with joint effusion in a controlled, double-blind, parallel group study. Plasma and synovial fluid concentrations of nimesulide, after a single and a repeated (14 days) dose, were also measured. The analgesic effect of nimesulide was more marked than for celecoxib. The percentage of patients who reported good or very good analgesic efficacy was 70% in the nimesulide group and 40% in the celecoxib group. After treatment with nimesulide the synovial fluid concentrations of SP and IL-6 were significantly lower than those measured at baseline. Nimesulide was shown to rapidly reach effective concentrations both in plasma and synovial fluid. The present results provide a new evidence that nimesulide is an effective agent for the treatment of painful OA, and may help explain the rapid onset of the analgesic action of this NSAID in patients with joint pain.

Published
2006

4. Covid-19 and clinical-epidemiological research in Italy: proposal of a research agenda on priority topics by the Italian association of epidemiology

Author

Giovannino, Ciccone, Silvia, Deandrea, Antonio, Clavenna, Ursula, Kirchmayer, Vittorio, Simeon, Anna, Acampora, Nerina, Agabiti, Laura, Angelici, Roita, Banzi, Ennio, Cadum, Anna, Castiglione, Paolo, Chiodini, Cinzia, Colombo, Eliana, Ferroni, Enrica, Migliore, Lorenza, Nisticò, Eva, Pagano, Anna Maria, Sabelli, Carlotta, Sacerdote, Caterina, Silvestri, Salvatore, Soldati, Saverio, Stranges, Marcello, Tirani, Marina, Davoli, Claudia, Galassi, Francesco, Forastiere, Ciccone, G., Deandrea, S., Clavenna, A., Kirchmayer, U., Simeon, V., Acampora, A., Agabiti, N., Angelici, L., Banzi, R., Cadum, E., Castiglione, A., Chiodini, P., Colombo, C., Ferroni, E., Migliore, E., Nistico, L., Pagano, E., Sabelli, A. M., Sacerdote, C., Silvestri, C., Soldati, S., Stranges, S., Tirani, M., Davoli, M., Galassi, C., and Forastiere, F.

Subjects
Adult, Male, Societies, Scientific, Epidemiology, Prognosi, epidemiologic methods, Coronavirus infections, pandemics, epidemiologic method, Pregnancy, Coronavirus infection, Humans, prevention and control, Pregnancy Complications, Infectious, Child, Pandemics, Aged, health services research evidence-based emergency medicine, Pandemic, SARS-CoV-2, Research, COVID-19, Middle Aged, Prognosis, COVID-19 Drug Treatment, Italy, Epidemiologic Research Design, Therapeutic Equipoise, Pregnancy Complications, Infectiou, Female, Human
Abstract

BACKGROUND: the Covid-19 pandemic has provoked a huge of clinical and epidemiological research initiatives, especially in the most involved countries. However, this very large effort was characterized by several methodological weaknesses, both in the field of discovering effective treatments (with too many small and uncontrolled trials) and in the field of identifying preventable risks and prognostic factors (with too few large, representative and well-designed cohorts orcase-control studies). OBJECTIVES: in response to the fragmented and uncoordinatedresearch production on Covid-19, the italian Association of Epidemiology (AIE) stimulated the formation of a working group (WG) with the aims of identifying the most important gaps in knowledge and to propose a structured research agenda of clinical and epidemiological studies considered at high priority on Covid-19, including recommendations on the preferable methodology. METHODS: the WG was composed by 25 subjects, mainly epidemiologists, statisticians, and other experts in specific fields, who have voluntarily agreed to the proposal. The agreement on a list of main research questions and on the structure of the specific documents to be produced were defined through few meetings and cycles of document exchanges. RESULTS: twelve main research questions on Covid-19 were identified, covering aetiology, prognosis,interventions, follow-up and impact on general and specific populations (children, pregnant women). For each of them, a two-page form was developed, structured in: background, main topics, methods (with recommendations on preferred study design and warnings for bias prevention) and an essential bibliography. CONCLUSIONS: this research agenda represents an initial contribution to direct clinical and epidemiological research efforts on high priority topics with a focus on methodological aspects. Further development and refinements of this agenda by Public Health Authorities are encouraged.

Published
2020

10. Osservazioni su due casi di poliploidia indotta in Vitis vinifera L. (cv. Barbera)

Author

Sacerdote, S., Vallania, R., Radicati, L., and Me, G.

Abstract

Vengono descritti gli aspetti citologici ed istologici di due viti cv. Barbera irraggiate con CO60 e present anti fenotipo poliploide. Le analisi compiute hanno riguardato il conteggio dei cromosomi negli apici radicali, l'osservazione degli strati epidermico e subepidermico delle gemme ibernanti, dei granuli pollinici, degli stomi, delle cellule dell'epidermide degli acini. Da tali osservazioni è emerso che un individuo è totalmente tetraploide, mentre il secondo è una chimera periclinale del tipo 2n-4n. Investigations on two cases of induced polyploidy in Vitis vinifera L. (cv. Barbera) The authors describe cytological and histological aspects of two grapevine plants, cv. Barbera, previously irradiated with CO60 and showing polyploid phenotype. The number of chromosomes in the root tip cells, the two first meristematic layers of wintering buds, the size of pollen grains, stornata, and epidermal cells of berries were investigated. The results show that one of them is a tetraploid grape, while the other was found to be a 2n-4n periclinal chimera., VITIS - Journal of Grapevine Research, Vol. 20 No. 4 (1981): Vitis

Published
2016
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32. Our experience in the treatment of acute myeloblastic leukemia

Author

E, Madon, P G, Baroncelli, A, Sacerdote, P L, Roberi, and L, Cordero di Montezemolo

Subjects
Male, Mercaptopurine, Daunorubicin, Cytarabine, Infant, Newborn, Infant, Antineoplastic Agents, Leukemia, Myeloid, Acute, Methotrexate, Vincristine, Child, Preschool, Humans, Drug Therapy, Combination, Female, Child, Thioguanine, Busulfan
Published
1974

33. Therapeutic results in neuroblastoma

Author

E, Madon, P G, Baroncelli, A, Sacerdote, L, Cordero di Montezemolo, and G, Pastore

Subjects
Male, Neuroblastoma, Child, Preschool, Humans, Infant, Antineoplastic Agents, Drug Therapy, Combination, Female, Child
Published
1976

34. I problemi sopradeterminati in Geodesia Fisica

Author

Sacerdote, F.

Subjects
Geoide, Geodesia física, Mediterráneo, Altimetría, Gravimetría
Abstract

Seminarios celebrados en el Instituto de Astronomía y Geodesia los días 19 y 21 de diciembre de 1989.

Published
1989

36. Neuroblastoma in the evolutive age

Author

E, Madon, P G, Baroncelli, A, Sacerdote, P L, Roberi, and L, Cordero di Montezemolo

Subjects
Male, Lung Neoplasms, Adolescent, Brain Neoplasms, Liver Neoplasms, Adrenal Gland Neoplasms, Infant, Newborn, Infant, Antineoplastic Agents, Bone Neoplasms, Radiography, Neuroblastoma, Child, Preschool, Lymphatic Metastasis, Humans, Female, Neoplasm Metastasis, Child
Published
1972

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