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3 results on '"STRIANO, PASQUALE"'

1. Il monitoraggio terapeutico della Cannabis medica nei pazienti pediatrici: l'esperienza dell'Istituto Giannina Gaslini.

Author

Cafaro, Alessia, Pigliasco, Federica, Barco, Sebastiano, Riva, Antonella, Striano, Pasquale, Manfredini, Luca, Barabino, Paola, Mattioli, Francesca, Pichini, Simona, Busardò, Francesco Paolo, and Cangemi, Giuliana

Abstract

The growing interest in medical Cannabis-based therapies has increased in recent years and treatment of drugresistant epilepsy is one of the most relevant applications. In Italy, the use of medical Cannabis is regulated by Ministerial Decree 9/11/2015. Medical Cannabis consists of dried female flowering tops that contain, among others, at least 90 cannabinoids. D9-tetrahydrocannabinol (THC) is the main psychotropic compound and cannabidiol (CBD) is the main non-psychotropic component. In recent years, a plant-derived pharmaceutical formulation of purified CBD in oral solution (Epidiolex®) has been approved as adjunctive therapy in combination with clobazam for drugresistant seizures associated with Dravet or Lennox-Gastaut syndrome. As of 2017, several Cannabis preparations, both magistral (oils and decoctions) and Epidyolex®, have been prescribed at Giannina Gaslini Pediatric Institute. To meet the clinical and regulatory needs, several Ultra High Performance Liquid Chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) methods have been developed and validated in our laboratory according to international guidelines for the validation of bioanalytical methods for the quantification of CBD, THC, cannabidiolic acid (CBD-A), tetrahydrocannabinolic acid (THC-A) and their main metabolites from various matrices (decoctions, oil preparations, plasma, volumetric absorptive microsampling devices). Results highlight the high inter-individual variability and large differences in bioavailability between purified and galenic preparations which underscore the need to implement Therapeutic Drug Monitoring (TDM) for personalization of medical Cannabis treatments. [ABSTRACT FROM AUTHOR]

Published
2023
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2. [Epilepsy genetics and genetic epilepsies]

Author

Striano, Pasquale, Bianchi, A., Zara, F., and Minetti, Carlo

Subjects
Epilepsy, Evidence-Based Medicine, Child, Epilepsy, genetics, Evidence-Based Medicine, Genetic Association Studies, Humans, Humans, genetics, Child, Genetic Association Studies
Published
2011

3. Epileptic seizures in multiple sclerosis: clinical and EEG correlations

Author

Salvatore Striano, P. Boccella, V. Brescia Morra, Giuseppe Orefice, C. Sarappa, Roberta Lanzillo, Pasquale Striano, G. Vacca, Striano, Pasquale, Orefice, Giuseppe, BRESCIA MORRA, Vincenzo, Boccella, P, Sarappa, C, Lanzillo, Roberta, Vacca, G, and Striano, Salvatore

Subjects
Male, Pediatrics, Neurology, etiology/pathology/physiopathology, Action Potentials, Electroencephalography, Epilepsies, Epilepsy, Recurrence, Secondary Prevention, Age of Onset, education.field_of_study, medicine.diagnostic_test, Brain, General Medicine, Middle Aged, Magnetic Resonance Imaging, physiology, Acute Disease, Adolescent, Adult, Age of Onset, Anticonvulsants, pharmacology/therapeutic use, Brain, pathology/physiopathology, Disease Progression, Electroencephalography, Epilepsies, Partial, etiology/pathology/physiopathology, Epilepsy, diagnosis/etiology/physiopathology, Female, Humans, Interferon-beta, pharmacology/therapeutic use, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, complications/diagnosis/physiopathology, Recurrence, prevention /&/ control, Retrospective Studies, diagnosis/etiology/physiopathology, Psychiatry and Mental health, Acute Disease, Disease Progression, Anticonvulsants, Female, Neurosurgery, medicine.symptom, Adult, medicine.medical_specialty, Multiple Sclerosis, Adolescent, Population, Dermatology, Status epilepticus, pharmacology/therapeutic use, pathology/physiopathology, medicine, Humans, education, Retrospective Studies, business.industry, Multiple sclerosis, Symptomatic seizures, Interferon-beta, medicine.disease, physiology, complications/diagnosis/physiopathology, prevention /&/ control, Epilepsies, Partial, Neurology (clinical), business
Abstract

Epileptic seizures occur more frequently in multiple sclerosis (MS) patients than in the general population. We evaluated clinical, electroencephalographic (EEG) and magnetic resonance imaging (MRI) findings, as well as EEG-MRI correlations and the response to antiepileptic drugs (AEDs) in 270 consecutive patients with definite MS referred to our Department from 1995 to 2002. Thirteen (4.8%) subjects experienced epileptic seizures. In four cases, seizures manifested within 1-2 years ("early-onset"), and in six cases within 8-23 years ("late-onset") of MS diagnosis. Seizures were usually partial with secondary generalization. Thus, acute symptomatic seizures occurred in three cases. Epilepsy usually appeared late in the course of disease, although a single episode or a cluster of seizures can represent the onset symptom or a relapse of MS. Prognosis of epilepsy during the course of MS is usually good but the choice of AEDs remains a matter of debate.

Published
2003

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