1. [Uremic coagulopathy. Role of thrombin].
- Author
-
Camici M and Sagripanti A
- Subjects
- Anticoagulants pharmacology, Anticoagulants therapeutic use, Antithrombins metabolism, Arteriosclerosis blood, Arteriosclerosis etiology, Blood Coagulation Disorders blood, Blood Platelets metabolism, Endothelium, Vascular metabolism, Factor Xa Inhibitors, Fibrinolysin metabolism, Hemorrhagic Disorders blood, Hemorrhagic Disorders etiology, Humans, Kidney Failure, Chronic blood, Kidney Failure, Chronic complications, Lipoproteins physiology, Models, Biological, Protein C metabolism, Receptor, PAR-1, Receptors, Thrombin drug effects, Receptors, Thrombin physiology, Solubility, Thrombin biosynthesis, Thrombin chemistry, Thrombophilia blood, Thrombophilia etiology, Uremia blood, Blood Coagulation Disorders etiology, Thrombin physiology, Uremia complications
- Abstract
The recent observation of increased thrombogenesis in chronic renal failure suggest a pathogenetic role of thrombin in hemorrhagic diathesis of chronic renal failure that may link two paradoxical aspects of this diathesis: hemorrhage and thrombosis. Not only: the accelerated atherosclerosis in uremic patient is also underlined. The possibility of thrombin therapeutic inhibition is then discussed.
- Published
- 2000