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1. Practice guidelines for the treatment of hepatitis C: recommendations from an AISF/SIMIT/SIMAST Expert Opinion Meeting

Author

Prati, D, Gasbarrini, A, Mazzotta, F, Sagnelli, E, Carosi, G, Abrescia, N, Alberti, Alfredo, Ambu, S, Andreone, P, Andriulli, A, Angelico, M, Antonucci, G, Ascione, A, Belli, Ls, Bruno, R, Bruno, S, Burra, Patrizia, Camma, C, Caporaso, N, Cariti, G, Cillo, U, Coppola, N, Craxi, A, DE LUCA, A, DE MARTIN, E, DI MARCO, V, Fagiuoli, S, Ferrari, C, Gaeta, Gb, Galli, M, Grieco, A, Grossi, P, Licata, A, Maida, I, Mangia, A, Marino, N, Maserati, R, Missale, G, Mondelli, M, Nasta, P, Niro, G, Persico, M, Petrelli, E, Picciotto, A, Piscaglia, F, Pollicino, T, Puoti, C, Puoti, M, Raimondo, G, Rumi, Mg, Santantonio, T, Smedile, A, Squadrito, G, Baroni, Gs, Taliani, G, Tavio, M, Toti, M, Bonino, F, Brunetto, Mr, Cacopardo, B, Caremani, M, Cauda, R, Colombo, M, DI PERRI, G, Donato, F, Farci, P, Fattovich, G, Filice, G, Ghinelli, F, Guadagnino, V, Lazzarin, A, Levrero, M, Licata, G, Orani, A, Paffetti, A, Pastore, G, Piccinino, F, Pizzigallo, E, Pontisso, Patrizia, Portelli, V, Rizzetto, M, Rossi, A, Stroffolini, T, Ubaldi, E, Santantanio, T, Alberti, A., Antonucci, Gf, Craxi, A., Prati D, Gasbarrini A, Mazzotta F, Sagnelli E, Carosi G, Abrescia N, Alberti A, Ambu S, Andreone P, Andriulli A, Angelico M, Antonucci GF, Ascione A, Belli LS, Bruno R, Bruno S, Burra P, Cammà, C, Caporaso N, Cariti G, Cillo U, Coppola N, Craxì, A, De Luca A, De Martin E, Di Marco, V, Fagiuoli S, Ferrari C, Gaeta GB, Galli M, Grieco A, Grossi P, Licata, A, Maida I, Mangia A, Marino N, Maserati R, Missale G, Mondelli M, Nasta P, Niro G, Persico M, Petrelli E, Picciotto A, Piscaglia F, Pollicino T, Prati D, Puoti C, Puoti M, Raimondo G, Rumi MG, Sagnelli E, Santantonio T, Smedile A, Squadrito G, Baroni GS, Taliani G, Tavio M, Toti M, Bonino F, Brunetto MR, Cacopardo B, Caremani M, Cauda R, Colombo M, Di Perri G, Donato F, Farci P, Fattovich G, Filice G, Ghinelli F, Guadagnino V, Lazzarin A, Levrero M, Licata G, Orani A, Paffetti A, Pastore G, Piccinino F, Pizzigallo E, Pontisso P, Portelli V, Rizzetto M, Rossi A, Stroffolini T, Ubaldi E., Italian Association for the Study of the Liver, Italian Society of Infectious, Tropical Disease, Italian Society for the Study of Sexually Transmitted Diseases: Prati D., Gasbarrini A., Mazzotta F., Sagnelli E., Carosi G., Abrescia N., Alberti A., Ambu S., Andreone P., Andriulli A., Angelico M., Antonucci G.F., Ascione A., Belli L.S., Bruno R., Bruno S., Burra P., Cammà C., Caporaso N., Cariti G., Cillo U., Coppola N., Craxì A., De Luca A., De Martin E., Di Marco V., Fagiuoli S., Ferrari C., Gaeta G.B., Galli M., Grieco A., Grossi P., Licata A., Maida I., Mangia A., Marino N., Maserati R., Missale G., Mondelli M., Nasta P., Niro G., Persico M., Petrelli E., Picciotto A., Piscaglia F., Pollicino T., Puoti C., Puoti M., Raimondo G., Rumi M.G., Santantonio T., Smedile A., Squadrito G., Baroni G.S., Taliani G., Tavio M., Toti M., Bonino F., Brunetto M.R., Cacopardo B., Caremani M., Cauda R., Colombo M., Di Perri G., Donato F., Farci P., Fattovich G., Filice G., Ghinelli F., Guadagnino V., Lazzarin A., Levrero M., Licata G., Orani A., Paffetti A., Pastore G., Piccinino F., Pizzigallo E., Pontisso P., Portelli V., Rizzetto M., Rossi A., Stroffolini T., Ubaldi E., Prati, D, Gasbarrini, A, Mazzotta, F, Sagnelli, E, Carosi, G, Abrescia, N, Alberti, A, Ambu, S, Andreone, P, Andriulli, A, Angelico, M, Antonucci, G, Ascione, A, Belli, L, Bruno, R, Bruno, S, Burra, P, Caporaso, N, Cariti, G, Cillo, U, Coppola, N, De Luca, A, De Martin, E, Fagiuoli, S, Ferrari, C, Gaeta, G, Galli, M, Grieco, A, Grossi, P, Maida, I, Mangia, A, Marino, N, Maserati, R, Missale, G, Mondelli, M, Nasta, P, Niro, G, Persico, M, Petrelli, E, Picciotto, A, Piscaglia, F, Pollicino, T, Puoti, C, Puoti, M, Raimondo, G, Rumi, M, Santantonio, T, Smedile, A, Squadrito, G, Baroni, G, Taliani, G, Tavio, M, Toti, M, Bonino, F, Brunetto, M, Cacopardo, B, Caremani, M, Cauda, R, Colombo, M, Di Perri, G, Donato, F, Farci, P, Fattovich, G, Filice, G, Ghinelli, F, Guadagnino, V, Lazzarin, A, Levrero, M, Licata, G, Orani, A, Paffetti, A, Pastore, G, Piccinino, F, Pizzigallo, E, Pontisso, P, Portelli, V, Rizzetto, M, Rossi, A, Stroffolini, T, and Ubaldi, E

Subjects
Liver Cirrhosis, ANTIVIRAL TREATMENT, Human immunodeficiency virus (HIV), HIV Infections, Hepacivirus, ANTIVIRAL THERAPY, PEGYLATED INTERFERON-ALPHA-2B, LIVER-TRANSPLANTATION, PEGINTERFERON ALPHA-2A, HIV-INFECTED PATIENTS, VIRUS-COINFECTED PATIENTS, RAPID VIROLOGICAL RESPONSE, Antiviral therapy, medicine.disease_cause, Gastroenterology, Polyethylene Glycols, HBV, guidelines, Acute hepatitis, Chronic hepatitis, Settore MED/12 - Gastroenterologia, liver transplantation, Hepatitis C, Recombinant Proteins, acute hepatitis, antiviral therapy, chronic hepatitis, cirrhosis, elderly patients, hbv, hcv, hdv, hiv, CLINICAL PRACTICE GUIDELINES, Cirrhosis, HCV, Drug Therapy, Combination, Antiviral therapy Acute hepatitis Chronic hepatitis,Cirrhosis, Elderly patients, HBV, HCV, HDV, HIV Liver transplantation, Elderly patient, Acute hepatiti, medicine.medical_specialty, Genotype, Alpha interferon, Interferon alpha-2, CHRONIC HEPATITIS C, Antiviral Agents, Hepatitis B, Chronic, Internal medicine, HDV, Drug Resistance, Viral, Ribavirin, medicine, Humans, Cirrhosi, Hepatology, business.industry, Settore MED/09 - MEDICINA INTERNA, Interferon-alpha, HIV, Hepatitis C, Chronic, medicine.disease, Elderly patients, Family medicine, Expert opinion, Chronic hepatiti, business
Abstract

It is increasingly clear that a tailored therapeutic approach to patients with hepatitis C virus infection is needed. Success rates in difficult to treat and low-responsive hepatitis C virus patients are not completely satisfactory, and there is the need to optimise treatment duration and intensity in patients with the highest likelihood of response. In addition, the management of special patient categories originally excluded from phase III registration trials needs to be critically re-evaluated. This article reports the recommendations for the treatment of hepatitis C virus infection on an individual basis, drafted by experts of three scientific societies.

Published
2010

4. An attempt to improve classification of HCV-correlated chronic hepatitis

Author

Pasquale G, Sagnelli E, Coppola N, Onofrio M, Scarano F, Scolastico C, Pf, Bellomo, Lettieri A, Ar, Mogavero, Caprio N, Sagnelli C, Piccinino F, Pasquale, Giuseppe, Sagnelli, E, Coppola, Nicola, Onofrio, M, Scarano, F, Scolastico, C, Bellomo, Pf, Lettieri, A, Mogavero, Ar, Caprio, N, Sagnelli, Caterina, and Piccinino, F.

Published
2005

5. Trattamento della Epatite da HCV

Author

Alberti A, Bonino F, Bortolotti F, Colombo M, Craxì A, Mele A, Rizzetto M, Almasio P, Androne P, Ascione A, Benvegnù L, Brunetto M, Bruno S, Cammaà C, Di Marco V, Fattovich G, Ferrari C, Ideo G, Levriero M, Pagliaro L, Pastore G, Piccinino F, Pontisso P, Puoti C, Puoti M, Raimondo G, Rumi MG, Saracco G, Santantonio T, Smedile A, Zignego L., BRILLANTI, STEFANO, MAZZELLA, GIUSEPPE, Alberti A, Bonino F, Bortolotti F, Colombo M, Craxì A, Mele A, Rizzetto M, Almasio P, Androne P, Ascione A, Benvegnù L, Brillanti S, Brunetto M, Bruno S, Cammaà C, Di Marco V, Fattovich G, Ferrari C, Ideo G, Levriero M, Mazzella G, Pagliaro L, Pastore G, Piccinino F, Pontisso P, Puoti C, Puoti M, Raimondo G, Rumi MG, Saracco G, Santantonio T, Smedile A, and Zignego L.

Subjects
TERAPIA, HCV, EPATITE
Published
2004

6. Infestazioni da Metazoi

Author

PICCININO F, SAGNELLI E, PICCININO R., PASQUALE, Giuseppe, TEODORI U, Piccinino, F, Pasquale, Giuseppe, Sagnelli, E, and Piccinino, R.

Published
2001

7. Malattie endemiche nelle aree tropicali

Author

PICCININO F, SAGNELLI E, PICCININO R., PASQUALE, Giuseppe, TEODORI, Piccinino, F, Pasquale, Giuseppe, Sagnelli, E, and Piccinino, R.

Published
2001

9. Epatite cronica persistente: risultati preliminari di uno studio multicentrico italiano

Author

Giusti, G., Gaeta, G. B., Galanti, B., Gallo, C., Piccinino, F., Ruggiero, G., Sagnelli, E., Ascione, A., Bianco, S., Borgia, G., Bortolotti, F., Brunetto, M., Cacciatore, L., Cesaro, G., Chiaramonte, M., Coltorti, M., Cozzolino, G., Dioguardi, F. S., Fattovich, Giovanna, Floreani, A., Frezza, M., Giacchino, R., Gottardi, E., Guadagnino, V., Linardi, C., Maggiore, G., Maio, G. G., Milella, M., Navone, C., Oldani, S., Pastore, G., Santantonio, T., Scalisi, I., Terragna, A., Vassallo, R., and Zancan, L.

Subjects
epatite cronica persistente, studio multicentrico, epatite cronica virale, prognosi
Published
1986

10. Le epatiti croniche da HCV

Author

GIUSTI G, RUSSO M, GALANTE D, PASQUALE G, SARDARO C, GALLO, Ciro, GIUSTI G, PICCININO F, GALANTI B, GAETA GB, Giusti, G, Russo, M, Galante, D, Pasquale, G, Sardaro, C, and Gallo, Ciro

Published
1992

11. [Virological and clinical aspects of multiple hepatitis virus infections: preliminary data of an italian multicentre study]

Author

Sagnelli E, Coppola N, Scolastico C, Filippini P, and Piccinino F

Abstract

To evaluate the interference between HBV, HCV and HDV and the clinical impact of coinfection as compared with single HBV or HCV infection, we unrolled 618 HBsAg and/or anti-HCV positive subjects (337 with liver biopsy and 281 without liver biopsy) at their first observation at one of the seven Italian Liver Units from 1993 to 1997 (Padova, Rome, Sassari, Naples, Bari, Messina, Palermo). Serum HBV-DNA by dot-blot was found more frequently in patients with HBV infection alone (52% of 133 cases) than in those with HBV-HCV coinfection (28% of 64 cases, p<0.005) or in those with HBV-HDV-HCV coinfection (12% of 25 cases, p<0.0005) or with HBV-HDV coinfection (13% of 8 cases, p<0.05). We observed a higher prevalence of HCV-RNA positive cases in the patients with HCV infection alone (91.2% of 114 cases) than in those with HBV-HCV coinfection (64.5% of 62 cases, p<0.0001) or with HBV-HDV-HCV infection (19% of 21 cases, p<0.0001). These observations suggest a reciprocal inhibition of HBV and HCV genome in multiple hepatitis viral infection. A severe liver disease was more frequently observed in patients with HBV-HCV coinfection (66%) than in those with a single HBV infection (43%, p<0.05) or HCV infection (46%, p<0.05). Anti-HCV positive/anti-HBc positive patients, lacking both HBsAg and anti-HBs, compared with the anti-HCV positive/anti HBc negative ones, more frequently showed severe clinical presentation and less frequently had a sustained response to a-IFN treatment.

Published
1999

12. [Anti-HAV screening patients with chronic hepatitis].

Author

Sagnelli E, Liorre G, Mogavero AR, Russello L, Rossi G, Filippini P, Felaco FM, and Piccinino F

Abstract

Following the decrease in HAV endemic levels in the last decades, nowadays in Italy most people aged less than 30 years are susceptible to the infection. We have tested for serum anti HAV IgG 194 chronic hepatitis patients from Naples to evaluate the level of protection against HAV in a category of patients in whom an acute necrosis due to HAV might induce liver failure. The study shows that 90.7% of Neapolitan chronic hepatitis patients has serologic evidence of prior HAV infection. Specifically, 98.1% of the patients over 40 years of age, but only 54.6% of those under 40 tested positive for anti HAV IgG. 102 patients had cirrhosis and only one tested negative. The data suggest that HAV vaccination in susceptible chronic hepatitis patients should be judged by the physicians in care on the basis of the severity of disease, patient's age, real risk of exposure to the infection, and level of education.

Published
1997

13. [HIV Antigens as complement fixing circulating immune complexes].

Author

Filippini P, Guarino M, Lapenta C, Marrocco C, Panico L, Messina V, Piccinino F, and Sagnelli E

Abstract

To detect HIV antigens in circulating complement fixing immune complexes (ICs) we assessed an ELISA using wells of microtitre plates coated with F(ab)2 anti-C3b and monoclonal antibodies anti-HIV gp120 and anti-HIV p24. We tested 24 anti-HIV positive subjects (Group A), 10 anti-HIV negative subjects at risk of acquiring HIV infection (Group B), 20 normal controls (Group C) and 2 seroconversion panels. We found HIV antigens in ICs in all sera from seroconversion panels, in 25.5% of sera from subjects in Group A, in 28.6% of sera from subjects in Group B and in no serum from subjects in Group C. A subject in Group B acquired HIV infection during the observation. HIV antigens in ICs by our assay were detected 8 months before Anti-HIV and Ag by commercial ELISA.

Published
1997

14. [Serum anti-HIV IgA in seropositive patients and in subjects at risk of HIV infection].

Author

Filippini P, Guarino M, Lapenta C, Marrocco C, Scolastico C, Panico L, Piccinino F, and Sagnelli E

Abstract

To detect the presence of anti-HIV IgA in HIV infected subjects and in seronegative subjects at risk of infection, we assessed a Western Blot using nitrocellulose strips with HIV separated proteins. We tested at least 2 different serum samples from 9 anti-HIV positive subjects (Group A), 9 anti-HIV negative subjects at risk of infection (Group B) and 9 controls (Group C). One subject in Group B became anti-HIV positive during the observation. Anti-HIV IgA were detected in all patients of Group A, in 66.6% of patients of Group B and in no patient of Group C. The subject who seroconverted during the observation showed positivity for IgA anti-HIV in both serum samples, while anti-HIV IgG became detectable only on the second serum sample. A newborn from a seropositive mother showed maternal anti-HIV IgG on the first 2 out of 3 serum samples while showed anti-HIV IgA positivity on the third sample only. This child is still anti-HIV negative.

Published
1997

15. [Polymerase chain reaction (PCR) for the detection of HIV proviral DNA (pDNA) in subjects at risk of infection].

Author

Panico L, Marrocco C, Scolastico C, Piccinino F, Filippini P, and Sagnelli E

Abstract

To detect HlV proviral DNA in lymphocytes from subjects at risk of acquiring HIV infection, we assessed a Polymerase Chain Reaction Assay using the SK38 and SK39 primers for the amplification and the SK19 probe for the hybridization. The detection of amplified HIV-DNA was obtained by a new colorimetric method, the DNA enzyme immunoassay (DEIA). The PCR we performed allowed to detect HIV-pDNA in lymphocytes of 13 out of 64 subjects at risk of acquiring HIV infection. Seven of these 13 became anti-HIV positive during a follow up of 8 months.

Published
1997

17. [Maternal-fetal transmission of hepatitis B virus. Follow-up study of 21 infants born to HBSAG-positive mothers, and 6 born to HBSAG-negative mothers with anti-HBV antibodies].

Author

Manzillo G, Sagnelli E, Da Villa G, Maio G, Izzo CM, Felaco F, Filippini P, Buonocore S, and Piccinino F

Subjects
Carrier State, Female, Hepatitis B transmission, Humans, Infant, Newborn, Pregnancy, Antibodies, Viral analysis, Hepatitis B immunology, Hepatitis B Antibodies analysis, Hepatitis B Surface Antigens analysis, Hepatitis B virus immunology, Maternal-Fetal Exchange
Abstract

Vertical transmission of hepatitis B virus (HBV) was studied in 21 mother-infant pairs. A transient HBs-antigenemia was observed in 60% of the 10 children born to HBsAg healthy carrier mothers and 91% of the 11 babies born to mothers with HBsAg-positive CAH. Among the 16 children showing HBs-antigenemia, 3 developed acute viral hepatitis two of whom showed progression to chronicity.

Published
1980

18. [Epidemiological evaluations of human immunodeficiency virus, herpes simplex virus type 1 and 2 and cytomegalovirus infections in drug addicts].

Author

Sagnelli E, Filippini P, Guarino M, Borrelli G, Aprea L, Malafronte G, Felaco FM, Piccinino F, and Giusti G

Subjects
Acquired Immunodeficiency Syndrome diagnosis, Adolescent, Adult, Cross-Sectional Studies, Cytomegalovirus Infections diagnosis, Female, Herpes Simplex diagnosis, Humans, Italy, Male, Risk Factors, Acquired Immunodeficiency Syndrome epidemiology, Cytomegalovirus Infections epidemiology, Herpes Simplex epidemiology, Substance-Related Disorders complications
Abstract

Eighty-eight drug addicts from the "BAN Center" in Torre Annunziata (Naples) and 88 normal subjects pair-matched for age and sex were tested for IgG to human immunodeficiency virus (HIV), herpes simplex virus (HSV) type 1 and 2 and cytomegalovirus (CMV). A high prevalence of subjects with antibodies to HSV-1 and CMV (80.7% and 65.9%) were recorded in the control group testifying to the high level of these infections in Campania. Prevalences were higher in drug addicts, and drug abuse was identified as a risk factor for the acquisition of CMV infection (odds ratio = 2.3). Moreover, drug addiction is also a risk factor for HSV-2 and HIV infection as demonstrated by the observation that drug abusers were anti-HSV-2 (9.1 vs. 1.1%, odds ratio = 6.16) or anti-HIV (11.4 vs. 0%, odds ratio = 23.6) positive more frequently than normal controls. Thus, drug addiction is a risk factor for the acquisition of HIV, HSV-2 and CMV infections. This is probably due to similar habits, frequent among drug addicts from our geographic area and uncommon in the normal population, such as tattooing, needle-sharing needlestick and unsafe sex. Some of these habits, such as unsafe sex and tattooing, seem to be, per se, risk factors for the acquisition of both HIV and CMV infections. The data also suggest that HIV infection was probably introduced in Campania more recently than in northern and central Italy where the prevalence of anti-HIV positive cases among drug addicts is definitely higher.

Published
1989

40. [Clinico-statistical study of the evolution of viral hepatitis in 272 subjects followed-up from the acute stage of the disease and in 150 subjects controlled for a period of 1-5 years after the acute episode of hepatitis].

Author

De Ritis F, Giusti G, Piazza M, Piccinino F, Da Villa G, and Manzillo G

Subjects
Acute Disease, Adolescent, Adult, Age Factors, Aged, Child, Child, Preschool, Chronic Disease, Female, Hospitalization, Humans, Infant, Italy, Male, Middle Aged, Prognosis, Sex Factors, Hepatitis, Hepatitis A epidemiology, Hepatitis A pathology
Published
1969

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