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Modifications in erythrocyte density distribution were evaluated, by means of centrifugation on Ficoll-Triosil discontinuous density gradient, in five healthy young women during menstrual cycle. Oestradiol and progesterone plasma levels were tested, showing normal and typically ovulatory-like variations during the cycle. Youngest cell populations showed always quantitative increases from the follicular to the ovulatory phase of the cycle, reverting to basal values in the luteal phase. Possible hormonal or haemorrhagic causes are discussed.

Differences in erythrocyte distribution on Ficoll-Sodium Metrizoate discontinuous density gradient were evaluated between adult males and females. Testosterone and androstenedione plasma levels were tested in males, oestradiol, progesterone and prolactin in both males and females. Female group showed a much higher proportion of lighter younger erythrocytes than males, while males showed higher proportion of denser older cells. Positive correlation was found between young cell percent and oestradiol level, both in males and females, but no correlation was found with androgen hormones.