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The abundant scientific literature on the addictions does not unclude many papers on the subject of sexual behaviors under the effect of self-administration of drugs. The results of the studies and of the experiments carried out in this field do not allow a classification of drugs in homogeneous groups according to their specific actions on sexual behavior. For each of the most common drugs the most reliable existing data have been examined. Final conclusions cannot be reached for each drug, since several substances may often act, according to many variables, in different cases as depressants or stimulants. The need to study this aspect of drug addiction has been underlined with the aim to improve our knowledge both in the field of the new sexual therapies and of the prevention and control of drug addiction.