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1. [Poorly differentiated breast carcinoma with an abundant myoepithelial component: morphologic and immunohistochemical features and mammaglobin gene expression ].

Author

Bonadio AG, Ferro P, Moroni M, Gorji N, Giannico A, Dessanti P, Fais F, Bacigalupo B, Roncella S, and Fedeli F

Subjects
Aged, Breast Neoplasms chemistry, Breast Neoplasms genetics, Carcinoma chemistry, Carcinoma genetics, Epithelial Cells chemistry, Female, Humans, Mammaglobin A, Myoepithelioma chemistry, Myoepithelioma genetics, Neoplasm Proteins analysis, Organ Specificity, Biomarkers, Tumor analysis, Breast Neoplasms pathology, Carcinoma pathology, Myoepithelioma pathology, Neoplasm Proteins genetics, RNA, Messenger analysis, RNA, Neoplasm analysis, Uteroglobin genetics
Abstract

In this report, we describe a case of poorly differentiate myoepithelial cell rich carcinoma in with morphological findings of large poligonal nests with festoon-like pattern sometimes showing central necrosis, reminiscent of a comedo-like pattern and numerous mitoses. Immunohistochemical staining shows positive reaction for cytokeratin AE/1, CAM 5.2, 34 beta E12, vimentin, smooth muscle actin, EMA, S100 protein and oncogene cERB.b2 and negative for estrogen, progesterone, GFAP and chromogranin. Moreover, this carcinoma show the expression of the mammaglobin mRNA, a highly specific marker of breast epithelial cells that it is not expressed in all breast carcinoma.

Published
2003

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