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A inteligência artificial é cada vez mais utilizada pelos médicos para o auxílio no diagnóstico de doenças. Essa tecnologia, por suas características, é capaz de gerar inúmeros benefícios, tais como permitir que procedimentos de diagnóstico médico sejam realizados de forma invariavelmente mais célere e normalmente mais precisa. Contudo, essa tecnologia é igualmente capaz de fomentar vieses cognitivos e interferir negativamente no processo de tomada de decisão do médico, podendo assim contribuir para a ocorrência de erros de diagnóstico. O presente trabalho apresenta justamente a possibilidade de ocorrência desses erros de diagnóstico decorrentes do viés da automação e o papel da responsabilidade civil do médico frente a essa nova problemática, analisando as diversas variáveis potencialmente ocorrentes. Utiliza-se a metodologia de pesquisa básica quanto à finalidade, descritiva quanto aos objetivos, qualitativa quanto à abordagem, dedutiva e dialética quanto ao método, e bibliográfica quanto ao procedimento.

The LiLa: Linking Latin project aims to build a Knowledge Base of language resources for the study of Latin (corpora, digital lexicons, natural-language-processing tools), based on the Linked Open Data paradigm. In this paper, we discuss the goals and motivation of the project. In particular, we focus on the role played by the lemma as a hub node that holds together the network of linguistic information. The architecture of LiLa is therefore based on lemmas and their morphological properties. The paper illustrates the strategies used to build a collection of Latin lemmas and the first experiments to link them to a set of textual resources (Latin treebanks).

IPERMOB proposes an information system for monitoring and management of urban mobility, using innovative and open technologies. From the architectural point of view, the system has three levels (tiers) that separate the issues relating to the collection and aggregation of data from those relating to publication of the information and use of services.

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A case of a 64-year-old man with eccrine carcinoma arising from hand skin is reported. At the time of diagnosis he showed bilateral pneumonic metastases. Although the patient underwent two systemic chemotherapy lines, he showed further progressive disease of the lung. For this reason a third chemotherapy line was started through thoracic stop-flow infusion. In this way, a five month stable disease had been achieved. The patient died 7 months later for progressive disease. The rarity of this disease, the uncertain treatment, the feasibility and efficacy of thoracic stop-flow infusion are underlined and further studies are suggested.

Intra-arterial hepatic chemotherapy (LAHC) results in significantly higher response rate than the best systemic treatment of liver metastases from colorectal cancer, but no survival advantage has to date shown because of extra-hepatic progression. From June 1991 to December 1994, twenty patients with hepatic metastases from colorectal cancer were enrolled. All patients underwent laparotomy for the placement of an intra-arterial catheter into the gastroduodenal artery connected with a subcutaneous port. All patients underwent cholecystectomy and biopsy of liver lesion to confirm metastatic disease. Locoregional schedule was: 5-fluorouracil (5FU) 500 mg/sqm, epirubicin (EPI) 13 mg/sqm, mitomycin-C (MMC) 7 mg/sqm, in bolus every 3 weeks. Systemic therapy consisted of leucovorin 500 mg/sqm, over 2 hours and 5FU 600 mg/sqm in bolus every week. Treatment was planned over a six month period. The complete response (CR) plus partial response (PR) rate was 50% of the entire group. The median survival was 18 months and 1- and 2- and 3-year survival rates were 71%, 38% and 20% respectively. Prior to chemotherapy, LDH value and % of liver involvement were the only significant prognostic parameters. Toxicity was absent or mild and no patient stopped treatment because of side effects. Combined systemic and IAHC is an effective treatment for liver metastases from colorectal cancer, with a mild or moderate toxicity. However, more trials are needed, to improve the control of the extrahepatic disease.

The authors describe five consecutive patients with testicular non Hodgkin lymphoma, evaluate the clinical and histological characteristics and underline the importance of a chemotherapy approach both at diagnosis and at relapse. A review of the literature is carried on and particularly about the prognostic factors, the correlation with Ebstein Barr virus and the more recent integrated therapeutical approaches.

The effect of different insulin concentrations on the deformability of normal red blood cells resuspended in different media was studied in vitro. Insulin enhances red blood cell deformability measured by the filtration method and the observed increases are directly correlated with insulin concentrations. When red blood cells are resuspended in plasma of diabetic patients, the red blood cell filterability through Nucleopore filters is slower than that observed by resuspending the erythrocytes in normal plasma. This suggests that the plasma of diabetic patients contains an unknown factor able to reduce red blood cell deformability.