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6 results on '"Kearns, A"'

1. Cost-utility analysis of brigatinib compared to alectinib in the treatment of ALK-positive NSCLC in patients previously not treated with an ALK inhibitor

Author

Roberto Ravasio, Holly Cranmer, Izzie Kearns, Raffaella Viti, and Simone Corinti

Subjects
Alectinib, ALK-positive, Brigatinib, Cost-utility, Italian NHS, NSCLC, Medicine
Abstract

Objective: The aim of this economic evaluation was to assess the cost-utility of brigatinib versus alectinib in the treatment of naïve patients to anaplastic lymphoma kinase-positive advanced non-small cell lung cancer (ALK-positive aNSCLC) from the perspective of the Italian National Health Service (INHS). Methods: A partitioned survival model with four health states (progression-free [PFS], no central nervous system progression [CNS-PFS], central nervous system progression [CNS-PD] and death) was used. The clinical data (progression-free survival, overall survival and time to progression) was based on the ALTA-1L trial for brigatinib and on ALEX trial for alectinib. Utility values were derived from EORTC QLQ-C30 scores evaluated in the ALTA-1L trial and literature. Costs included frontline therapies, subsequent therapies, best supportive care (BSC), administration, concomitant medications, adverse events and health states. Direct medical costs and benefits (quality-adjusted life-years, QALYs) were discounted at a 3.0% annual rate. Uncertainty was assessed using deterministic (DSA) and probabilistic sensitivity analyses (PSA). Results: The analysis showed that brigatinib was dominant versus alectinib; brigatinib led to a gain of 0.216 QALYs and to a treatment cost reduction of € 85,635. The results of the DSA showed that no parameters of the model significantly modified the base case result. Conclusions: This economic evaluation suggested that, compared with alectinib, brigatinib can be considered a valid cost-utility option from the perspective of INHS in the treatment of patients with ALK-positive aNSCLC.

Published
2022
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2. High variability of Panton-Valentine Leukocidine producing methicillin-resistant Staphylococcus aureus isolated from skin and soft tissue infections in the province of Bolzano

Author

Richard Aschbacher, Bruno Pichon, Greta Spoladore, Elisabetta Pagani, Patrizia Innocenti, Ludwig Moroder, Renate Meyer, Brigitte Ladinser, Mark Ganner, Robert Hill, Rachel Pike, Oswald Ganthaler, Leonardo Pagani, Clara Larcher, and Angela Kearns

Subjects
CA-MRSA, SCCmec,ACME, PVL, ST93, Microbiology, QR1-502
Abstract

Introduction. Panton-Valentine leukocindin (PVL) positive community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates are widespread in many countries, with varying distribution and epidemiology. The aim of this study was to characterise the ten PVL positive MRSA isolates collected during February 2010 to January 2011 from skin and soft tissue infections in the North Italian Province of Bolzano. Methods. Accessory gene regulator (agr) typing, staphylococcal cassette chromosome (SCC) mec typing, spa typing,multi-locus sequence typing (MLST), toxin gene profiling, PCR for type I arginine catabolic mobile element (ACME) and antimicrobial resistance typing were applied to the isolates. Results. Eight different CA-MRSA clones were identified: ST30-IVc, ST772-V, ST80-IVc, ST5-IVc, ST88-IVa, ST93- IVa, ST8-IVc and the type I ACME positive ST8-IVa. Conclusions. The high heterogeneity of PVL-positive MRSA probably reflects the introduction of different clones by international travellers or immigrants.

Published
2012
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5. Search for GUT monopoles with the MACRO streamer tube and track etch systems

Author

Sciubba, A., Ambrosio, M., Antolini, R., Auriemma, G., Baker, R., Baldini, A., Barbarino, Gc, Barish, Bc, Battistoni, G., Bellotti, R., Bemporad, C., Bernardini, P., Bilokon, H., Bisi, V., Bloise, C., Bosio, T., Bower, C., Bussino, S., Cafagna, F., Calicchio, M., Campana, D., Carboni, M., Castelliano, M., Cecchini, S., Cei, F., Chiarella, V., Corona, A., Coutu, S., Decataldo, G., Dekhissi, R., Demarzo, C., Mitri, I., Devincenzi, M., Dicredico, A., Erriquez, O., Fantini, R., Favuzzi, C., Forti, C., Fusco, P., Giacomelli, G., Giannini, G., Giglietto, N., Grassi, M., Grillo, A., Guarino, F., Guarnaccia, P., Gustavino, C., Habig, A., Hanson, K., Hawthorne, A., Heinz, R., Hong, Jt, Iarocci, E., Katsavounidis, E., Kearns, E., Kyriazopoulou, S., Lamanna, E., Lane, C., Levin, Ds, Lipari, P., Liu, G., Liu, R., Longley, Np, Longo, Mj, Lu, Y., Ludlam, G., Mancarella, G., Mandrioli, G., Margiottaneri, A., Marini, A., Martello, D., Marzarichiesa, A., Mazziotta, Mn, Michael, Dg, Mikheyev, S., Miller, L., Mittelbrunn, M., Monacelli, P., Montaruli, T., Monteno, M., Mufson, S., Musser, J., Nicolo, D., Nolty, R., Okada, C., Orth, C., Osteria, G., Palamara, O., Parlati, S., Patera, V., Patrizii, L., Pazzi, R., Peck, Cw, Petrera, S., Pignatano, Nd, Pistilli, P., Popa, V., Raino, A., Reynoldson, J., Ronga, F., Rubizzo, U., Sanzgiri, A., Sartogo, F., Celestina Satriano, Satta, L., Scapparone, E., Scholberg, K., Serralugaresi, P., Severi, M., Sitta, M., Spada, Pf, Spinelli, P., Spinetti, M., Spurio, M., Steinberg, R., Stone, Jl, Sulak, Lr, Surdo, A., Tarle, G., Togo, V., Valente, V., Walter, Cw, Webb, R., M., Ambrosio, R., Antolini, G., Auriemma, R., Baker, A., Baldini, Barbarino, Giancarlo, B., Barish, G., Battistoni, R., Bellotti, C., Bemporad, P., Bernardini, H., Bilokon, V., Bisi, C., Bloise, T., Bosio, C., Bower, S., Bussino, F., Cafagna, M., Calicchio, D., Campana, M., Carboni, M., Castellano, S., Cecchini, F., Cei, V., Chiarella, I., Corona, S., Coutu, G., Decataldo, H., Dekhissi, C., Demarzo, R., Demitri, M., Devincenzi, A., Dicredico, O., Erriquez, R., Fantini, C., Favuzzi, C., Forti, P., Fusco, G., Giacomelli, G., Giannini, N., Giglietto, M., Grassi, A., Grillo, Guarino, Fausto, P., Guarnaccia, C., Gustavino, A., Habig, K., Hanson, A., Hawthorne, R., Heinz, J. T., Hong, E., Iarocci, E., Katsavounidi, E., Kearn, S., Kyriazopoulou, E., Lamanna, C., Lane, D. S., Levin, P., Lipari, G., Liu, R., Liu, N. P., Longley, M. J., Longo, Y., Lu, G., Ludlam, G., Mancarella, G., Mandrioli, A., Margiotta Neri, A., Marini, D., Martello, A., Marzari Chiesa, M. N., Mazziotta, D. G., Michael, S., Mikheyev, L., Miller, M., Mittelbrunn, P., Monacelli, T., Montaruli, M., Monteno, S., Mufson, J., Musser, D., Nicolo, R., Nolty, C., Okada, C., Orth, G., Osteria, O., Palamara, S., Parlati, V., Patera, L., Patrizii, R., Pazzi, C. W., Peck, S., Petrera, N. D., Pignatano, P., Pistilli, V., Popa, A., Raino, J., Reynoldson, F., Ronga, U., Rubizzo, A., Sanzgiri, F., Sartogo, C., Satriano, L., Satta, E., Scapparone, K., Scholberg, A., Sciubba, P., Serra Lugaresi, M., Severi, M., Sitta, P. F., Spada, P., Spinelli, M., Spinetti, M., Spurio, R., Steinberg, J. L., Stone, L. R., Sulak, A., Surdo, G., Tarle, V., Togo, V., Valente, C. W., Walter, and R., Webb

Published
1995

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