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Introduction: Meckel’s diverticulum (MD) is usually asymptomatic but may be associated with severe complications that require awareness. This study aimed to assess the clinical and pathological features of symptomatic MD in children as well as the accuracy of [99mTc]sodium pertechnetate scintigraphy. Methods: We retrospectively reviewed all symptomatic MD in pediatric patients treated between 2007 and 2018 at a tertiary center. Records included demographics, clinical presentation, scintigraphy with [99mTc]sodium pertechnetate, surgical outcome, and histopathology. Results: There were 47 patients (93.6% males) with a median age of 4.31 [1.76-8.10] years. The most common clinical presentation was digestive bleeding (n = 25, 53.2%), followed by intestinal obstruction (n = 12, 25.5%) and diverticulitis (n = 10, 21.3%). The patients with digestive bleeding were younger than those with intestinal obstruction or diverticulitis (2.76 vs. 6.02 years). All patients with digestive bleeding underwent scintigraphy that revealed ectopic gastric mucosa in 23. From the 23 positive scintigraphy, there were 22 available histological exams, from which 21 revealed ectopic gastric mucosa; the 2 negative scintigraphy studies also revealed ectopic gastric mucosa. Therefore, scintigraphy revealed a sensitivity of 91.3% (21/23) in patients presenting digestive bleeding. In the conclusive histological exams (n = 41), ectopic mucosa was detected in 82.9% of cases: 96% in digestive bleeding, 71% in intestinal obstruction, and 60% in diverticulitis. With a median follow-up of 7.2 years, there were no mortality or major complications. Conclusion: Symptomatic MD predominated in males, the digestive bleeding occurring at younger ages. Scintigraphy demonstrated high sensitivity in the detection of ectopic gastric mucosa in patients with digestive bleeding. Overall symptomatic MD usually has ectopic mucosa. Although the surgical outcome is excellent, complications of MD should be kept in mind.

We report an unusual case of ileal intussusception in a 7-year-old girl affected by Peutz Jeghers syndrome, characterized by a very misleading clinical presentation, resembling chronic constipation. Correct diagnosis was guided through appropriate knowledge of inherited condition and cautious ultrasound monitoring. Confirmation was achieved by a timely surgical intervention and subsequent pathologic examination.

This report analyses the serious side effects of rotavirus vaccine with particular regard to intussusception, especially in light of the reasons which prompted the French health authorities to suspend, in April 2015, the previously approved recommendation of universal vaccination. Considering the current scientific evidence and the well motivated guidelines set by other European countries, the authors conclude that there are no reasons at the present time to suspend the universal offer of anti-rotavirus vaccination to infants, since it shows a favourable benefit-risk ratio and it is characterized by an excellent cost-effectiveness profile.