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6. [The therapy of arterial hypertension: a comparison between ACE inhibitors and angiotensin-II-receptor antagonists].

Author

Rossi F, Mangrella M, Paternò E, Imperatore F, Capristo M, Imperatore C, and Guarino A

Subjects
Animals, Drug Evaluation, Drug Evaluation, Preclinical, Humans, Receptors, Angiotensin drug effects, Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Antihypertensive Agents therapeutic use, Hypertension drug therapy
Abstract

The efficaciousness of ACE inhibitors in arterial blood hypertension is well known. These drugs decreased the incidence of hypertension and myocardial infarction in population. However, they increase tissue levels of some kinines, that may be responsible of some adverse reactions (cough, etc.). Angiotensin-receptor antagonists can minimize the adverse reactions due to kinine accumulation and may increase the safety of the antihypertensive drug-treatment. Pharmacological and clinical aspects of angiotensin-receptor antagonists are discussed.

Published
1996

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