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9 results on '"Girelli D"'

1. PROTOCOLLO ECOGRAFICO DEL PAZIENTE CON SCOMPENSO CARDIACO: RISULTATI AGGIORNATI DELLO STUDIO MULTICENTRICO SIUMB ABCDE 2018-2022

Author

Mozzini C., Soresi M., Pesce G., Girelli D, and Mozzini C., Soresi M., Pesce G., Girelli D

Subjects
Lung ultrasound , Internal medicine, heart failure, Doppler, Settore MED/09 - Medicina Interna
Abstract

Lo scompenso cardiaco è una sindrome clinica caratterizzata da specifici segni e sintomi causati da anomalie cardiache di tipo strutturale e/o funzionale. La prevalenza dello scompenso cardiaco è di circa 1-2% nella popolazione adulta dei paesi industrializzati, aumenta fin oltre il 10% oltre i 70 anni ed è la maggiore causa di ospedalizzazione oltre che di disabilità. L’approccio ecografico al paziente con scompenso cardiaco è ad oggi pratica comune, sia per la valutazione della funzionalità cardiaca, sia per il monitoraggio dello stato di volemia che per la quantificazione del liquido interstiziale. Dal 2018 è in corso uno studio multicentrico italiano (“ABCDE”) patrocinato dalla SIUMB che ha come centro promotore il reparto di Medicina Generale e Malattie Aterotrombotiche e Degenerative dell’Università di Verona. L’ approccio ecografico proposto comprende le valutazioni di: A: ABI (Ankle Brachial Index), indice caviglia-braccio; B: linee B all’ecografia polmonare; C: CIMT (Carotid Intima Media Thickness), spessore intima-media carotideo; D: Diametro dell’aorta addominale e della vena cava inferiore; E: stima ecocardiografica della frazione di eiezione ventricolare sinistra. Questa presentazione riporta i risultati aggiornati a poco più di un anno dall’avvio dello studio riportando i dati provenienti dal centro promotore (Verona) e dai centri partecipanti. Dai primi risultati dello studio "ABCDE", la metodica ecografica nel paziente con scompenso cardiaco, intesa sia come “bedside” che come approccio ecografico integrato appare essere uno strumento essenziale di valutazione cardiovascolare globale, e di accorciamento della durata della degenza nei reparti medici.

Published
2019

2. Associazione di polimorfismi del cluster dei geni FADS1 e FADS2 con i livelli di acidi grassi polinsaturi in malattie coronariche

Author

Malerba, Giovanni, Xumerle, Luciano, Trabetti, Elisabetta, Cavallari, Ugo Antonio Aristide, Biscuola, M., Galavotti, Roberta, Cavallari, U., Pasquali, Alessandra, Galavotti, R., Martinelli, Nicola, Pasquali, A., Girelli, Domenico, Martinelli, N., Olivieri, Oliviero, Girelli, D., Corrocher, Roberto, Olivieri, O., Pignatti, Pierfranco, Corrocher, R., Illig, T., and Pignatti, P. F.

Subjects
FADS genes, malattia coronarica, associazione
Published
2006

5. [Genetic risk factors in ischemic cardiopathy].

Author

Girelli D and Martinelli N

Subjects
Hemostasis, Humans, Lipoproteins metabolism, Myocardial Ischemia epidemiology, Myocardial Ischemia metabolism, Risk Factors, Myocardial Ischemia genetics
Abstract

Coronary artery disease is a complex disease, characterized by a myriad of interactions between environmental and genetic factors. There is a growing interest about the genetic components. This research field is rapidly growing, and could offer new diagnostic and therapeutic tools in a near future. This paper will focus on common variations in several candidate genes. They have been categorized into three groups, according to different pathophysiological mechanisms: 1) lipid metabolism; 2) hemostatic balance; 3) non-lipid metabolism.

Published
2001

6. ["Hyperferritinemia-cataract syndrome." Description of a new hereditary disease, from anamnesis to molecular diagnosis].

Author

Girelli D, Piccoli P, and Corrocher R

Subjects
Adult, Ferritins genetics, Humans, Male, Syndrome, Cataract diagnosis, Cataract genetics, Ferritins blood
Abstract

A new autosomal-dominant genetic disorder, which has been recently identified by our group is described. The disease is clinically characterized by the combination of a substantial increase of serum ferritin and early-onset bilateral cataract. Moreover, it is clearly distinguishable from genetic hemochromatosis because of: 1) normal to low serum iron and transferrin saturation, without evidence of parenchymal iron overload; 2) the dominant transmission; 3) the lack of any relation with HLA; 4) the rapid development of iron-deficient anemia when unnecessary phlebotomies are performed. The molecular basis of the new syndrome is a mutation in the L-subunit ferritin gene on chromosome 19 (19q13.3-->19qter). The mutation involves a five nucleotide sequence [CAGUG] of the iron-responsive-element (IRE), which is critical for the post-transcriptional regulation of ferritin synthesis by means of the binding with an Iron Regulatory Protein. As a consequence, ferritin synthesis is up-regulated, irrespective of cell iron status.

Published
1997

7. [Effectiveness of loratadine vs. placebo in the treatment of urticaria-angioedema syndrome in patients with food allergy].

Author

Pacor ML, Biasi D, Girelli D, Cortina P, and Corrocher R

Subjects
Adult, Angioedema drug therapy, Double-Blind Method, Drug Evaluation, Female, Food Hypersensitivity drug therapy, Humans, Loratadine adverse effects, Male, Placebos, Sleep Stages drug effects, Syndrome, Urticaria drug therapy, Xerostomia chemically induced, Angioedema complications, Food Hypersensitivity complications, Loratadine therapeutic use, Urticaria complications
Abstract

Loratadine is a new, highly selective, non sedating, H 1-receptor antagonist, without central nervous system activity. In a randomized double-blind, crossover study, we evaluated the effects of loratadine and placebo administered once daily in 184 food intolerant patients affected by urticaria-angioedema. The difference between loratadine and placebo treatment was significant in relieving symptoms. Adverse reactions reported in the treatment were mild, in fact somnolence was reported by 3.4%, dry mouth by 2.2% of patients.

Published
1993

8. [Ion transport in erythrocytes: a universal physiological model. Reflections on the pathogenesis of hypertension].

Author

Olivieri O, Girelli D, and Corrocher R

Subjects
Biological Transport, Erythrocyte Membrane metabolism, Homeostasis, Humans, Hypertension blood, Hypertension metabolism, Lithium blood, Lithium metabolism, Membrane Lipids metabolism, Sodium blood, Sodium metabolism, Erythrocytes metabolism, Hypertension etiology
Abstract

The red cell represents a useful model for the study of general pathophysiological mechanisms, because of its availability and the relative easiness of the methodological approach due to the absence of nucleus and organelles. Particularly, most of the transmembrane ion transport systems, which control the homeostasis of intra- and extracellular electrolytes, have been firstly discovered in the red cell membrane. The pathophysiological importance of these transport systems is often extended to non haematological diseases like essential hypertension. Several reports from different laboratories have established that the red cell Na+/Li+ countertransport is stimulated in patients with essential hypertension. The regulation of Na+/Li+ countertransport, relationship with plasma and membrane lipids and the possibility of modulating its activity by dietary interventions, are focused in the last part of this review.

Published
1991

9. [Endogenous erythrocyte proteolysis: a new approach to the study of membrane physiopathology].

Author

Vettore L, De Mattels MC, Bonollo E, De Angelis V, Sorrentino F, Trevisan T, Guarini P, Girelli D, and Olivieri O

Subjects
Blood Preservation, Cations metabolism, Cell Membrane Permeability drug effects, Erythrocyte Membrane drug effects, Hematologic Diseases blood, Humans, Lead Poisoning blood, Liver Cirrhosis blood, Membrane Proteins metabolism, Oxidants pharmacology, Oxidation-Reduction, Blood Proteins metabolism, Endopeptidases blood, Erythrocyte Membrane metabolism
Published
1991

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