1. [Heavy metal! A case of severe iron overload and supraventricular arrhythmias in a thalassemia major patient].
- Author
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Marchini F, Fiorio A, Sirugo P, Gamberini MR, Mari E, Bertini M, and Malagù M
- Subjects
- Arrhythmias, Cardiac etiology, Arrhythmias, Cardiac therapy, Humans, Iron therapeutic use, Iron Chelating Agents therapeutic use, Heart Diseases complications, Iron Overload complications, Iron Overload drug therapy, Metals, Heavy therapeutic use, beta-Thalassemia drug therapy, beta-Thalassemia therapy
- Abstract
Cardiovascular complications are among the main causes of mortality and morbidity in patients with thalassemia major. Iron-chelation therapy is essential to prevent the chronic iron overload linked to the need for transfusions and the consequent cardiac hemosiderosis. Despite the wide use of iron-chelation drugs, today it is still possible to find cases of severe iron accumulation. Furthermore, even regardless of iron overload and cardiac dysfunction, the thalassemic patient has a high arrhythmic burden, especially for supraventricular arrhythmias. There are still many doubts and open questions about the management of such patients, especially regarding the correct use of anticoagulant therapy and the best utilization of therapeutic strategies available for rhythm control. The case presented shows how the interventional approach with catheter ablation can be useful also in the acute phase when antiarrhythmic drugs are ineffective and it is not possible to wait for the iron-chelation therapy to take effect.
- Published
- 2022
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