Search

Your search keyword '"Del Curto, B."' showing total 6 results
Start Over Author "Del Curto, B." Language italian
6 results on '"Del Curto, B."'

6. [Surfactant protein and thyroid transcription factor 1 in pleuro-pulmonary neoplasia. Immunohistochemical study].

Author

Dessy E, Falleni M, Del Curto B, Braidotti P, and Pietra GG

Subjects
Adenocarcinoma chemistry, Adenocarcinoma diagnosis, Adenocarcinoma secondary, Carcinoma chemistry, Carcinoma pathology, Carcinoma secondary, Colorectal Neoplasms chemistry, Diagnosis, Differential, Humans, Lung Neoplasms chemistry, Lung Neoplasms pathology, Lung Neoplasms secondary, Lymphatic Metastasis, Mesothelioma chemistry, Mesothelioma pathology, Pleural Neoplasms chemistry, Pleural Neoplasms pathology, Pleural Neoplasms secondary, Protein Precursors analysis, Pulmonary Surfactant-Associated Protein A, Pulmonary Surfactant-Associated Protein D, Pulmonary Surfactant-Associated Proteins, Thyroid Nuclear Factor 1, Biomarkers, Tumor analysis, Carcinoma diagnosis, Glycoproteins analysis, Immunoenzyme Techniques, Lung Neoplasms diagnosis, Mesothelioma diagnosis, Neoplasm Proteins analysis, Nuclear Proteins analysis, Pleural Neoplasms diagnosis, Proteolipids analysis, Pulmonary Surfactants analysis, Transcription Factors analysis
Abstract

Aim of this work was to investigate the ability of the antibodies against Surfactant proteins (SP) and Thyroid transcription factor 1 (TTF-1) to distinguish primary neoplasms of the lung from metastatic carcinomas to the lung and pleural mesotheliomas. We evaluated the immunohistochemical expression of the antibodies anti SP-A, SP-B, pro SP-C, SP-D, and TTF-1 in a series of 56 primary lung carcinomas, 9 metastatic carcinomas to the lung, 5 pleural mesotheliomas and 8 non-pulmonary carcinomas. Among primary lung neoplasms, only adenocarcinomas immunostained for all SP (specificity = 1; total sensitivity = 0.52). TTF-1 had an excellent specificity (= 1), but a weak sensitivity (= 0.34) in recognizing primary lung carcinomas. TTF-1 was present in lung adenocarcinomas which were negative for SPs; however it failed to distinguish the subtypes. Pleural mesotheliomas, pulmonary metastases and non-pulmonary carcinomas were not immunoreactive for SP-A, SP-B, SP-D, and TTF-1. Pro SP-C was positive also in the adenocarcinomas of the large bowel and in their pulmonary and nodal metastases. These results demonstrate that the combined use of antibodies anti SP-A, SP-B and TTF-1 is the best association in distinguishing primary lung carcinomas from metastatic carcinomas to the lung and pleural mesotheliomas.

Published
2000

Catalog

Books, media, physical & digital resources
See catalog results