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1. [Sulfonamides with central nervous system action. V].

Author

Monzani A, Di Bella M, Braghiroli D, Raffa L, and Sandrini M

Subjects
Animals, Electroshock, Female, Mice, Pentylenetetrazole antagonists & inhibitors, Sulfonamides pharmacology, Anticonvulsants chemical synthesis, Sulfonamides chemical synthesis
Abstract

A series of 2-nitro and 2-aminobenzenesulfon-N-acylamides variously substituted on the benzene ring were prepared and tested for anticonvulsant activity (electro shock, pentamethylenetetrazole). Some of the compounds tested gave some measure of protection against convulsions induced by electric shock. The importance of the trifluoromethyl substituent in this effect was demonstrated.

Published
1982

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