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Your search keyword '"Biella, F."' showing total 5 results
Start Over Author "Biella, F." Language italian
5 results on '"Biella, F."'

1. Riabilitazione degli operatori ospedalieri affetti da patologie muscolo-scheletriche: analisi dei risultati dei primi 24 mesi di attivazione di un percorso intraziendale dedicato

Author

RIVA, MICHELE AUGUSTO, Biella, F, Rodella, C, Mauri, O, Latocca, R, D'ORSO, MARCO ITALO, DE VITO, GIOVANNI, CESANA, GIANCARLO, Riva, M, Biella, F, Rodella, C, Mauri, O, D'Orso, M, DE VITO, G, Latocca, R, and Cesana, G

Subjects
patologie muscolo-scheletriche, sorveglianza sanitaria, riabilitazione, MED/44 - MEDICINA DEL LAVORO
Published
2014

2. IgVH mutational status in chronic lymphocytic leukemia: Evalutaion of reference databases [Stato mutazionale del gene IgVH nella leucemia linfatica cronica: Valutazione dei 'database' di riferimento]

Author

Cappellani, A, Cappellini, F, Biella, FM, Sciarini, F, Parma, C, Limonta, G, Mocarelli, P, BRAMBILLA, PAOLO, Cappellani, A, Cappellini, F, Biella, F, Sciarini, F, Parma, C, Limonta, G, Mocarelli, P, and Brambilla, P

Subjects
IgVH, Chronic Lymphocytic Leukemia, GenBank/IgBlast, IMGT
Abstract

An important prognostic factor in patients with chronic lymphocytic leukemia (CLL) is the mutational status of immunoglobulin heavy chain variable region genes (IgVH), whose determination depends on the comparison between the nucleotide sequence of IgVH expressed by the leukemic clone of the patient and the germ line of the concerned family. If the calculated homology is >98%, the patient is deemed unmutated and the clinical course is unfavorable. Two reference database custodians of nucleotide sequences of the germ line [GenBank/IgBlast and Immunogenetics Information System (IMGT)] are the most accessed for the comparison. The aim of this work was to evaluate what database provides a more accurate assessment of the IgVH mutational status. The latter was examined by automated sequencing in patients with CLL (n = 204) and the percentage of homology was assessed by both databases. The analysis revealed that in six patients the two databases assigned a different family, because some alleles or families are present only in IgVH dataset of IMGT. When IgVH family was the same in both databases, the percentage of homology showed a difference in 50% of the subjects. Depending on the database used for comparison, six subjects, with homology close to 98%, have a different mutational status with associated different prognosis estimate. In conclusion, the IMGT database is more comprehensive and updated allowing to define the percentage of homology, and therefore the prognostic value, more accurately.

Published
2010

4. [Evaluation of risk factors in the development of postoperative complications in patients undergoing liver resection for cancer].

Author

Staudacher C, Chiappa A, Zbar AP, Bertani E, Biella F, and Haizhen Z

Subjects
Adult, Aged, Aged, 80 and over, Bile Duct Neoplasms complications, Bile Duct Neoplasms surgery, Bile Ducts, Intrahepatic surgery, Carcinoma, Hepatocellular complications, Cholangiocarcinoma complications, Cholangiocarcinoma surgery, Colorectal Neoplasms pathology, Data Interpretation, Statistical, Female, Humans, Liver Cirrhosis complications, Liver Neoplasms complications, Liver Neoplasms secondary, Male, Melanoma secondary, Melanoma surgery, Middle Aged, Risk Factors, Sarcoma secondary, Sarcoma surgery, Stomach Neoplasms pathology, Carcinoma, Hepatocellular surgery, Hepatectomy, Liver Neoplasms surgery, Postoperative Complications etiology
Abstract

A consecutive series of 134 hepatic resections for primary and metastatic cancer were analyzed to identify the risk factors for post-operative complications in patients with and without impaired liver reserve. Between January 1992 and January 2000 were performed 55 hepatectomies (41%--group 1) in 54 cirrhotic patients for hepatocarcinoma and 79 hepatic resections (59%--group 2) in 66 patients for primary hepatic malignancies or metastatic liver tumours in non cirrhotic liver. Among major postoperative complications bile leakage was recorded in 8 patients (6%) (6% with impaired liver reserve and 6% with normal reserve), hepatic failure in 8 patients (6%) (9% vs 4%; P = NS), ascites in 7 patients (5%) (11% vs 1%; P = 0.01), pneumonia in 4 patients (3%) (5% vs 1%; P = NS), intra-abdominal abscess in 2 patients (1%) (2% vs 1%; P = NS), postoperative haemorrhage in 2 patients (1%) (4% vs 0; P = NS), and gastrointestinal bleeding in 2 patients (1%) (4% vs 0; P = NS). There were 6 perioperative deaths (4%) (7% vs 2%; P = NS). The mean hospital stay was 21 +/- 10 days (range: 5-57) (24 +/- 10 vs 20 +/- 10; P = 0.02). Liver resection is a safe procedure even in cirrhotic patients providing they are well selected and there is minimal intraoperative blood loss.

Published
2000

5. [Hepatic resection for hepatocarcinoma in the cirrhotic patient].

Author

Chiappa A, Zbar AP, Bertani E, Biella F, and Staudacher C

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Hepatocellular mortality, Female, Follow-Up Studies, Humans, Liver Cirrhosis mortality, Liver Neoplasms mortality, Male, Middle Aged, Neoplasm Recurrence, Local epidemiology, Survival Rate, Carcinoma, Hepatocellular complications, Carcinoma, Hepatocellular surgery, Hepatectomy, Liver Cirrhosis complications, Liver Cirrhosis surgery, Liver Neoplasms complications, Liver Neoplasms surgery
Abstract

Between January 1993 and June 1999, 54 patients with hepatocellular carcinoma (HCC) complicating cirrhosis underwent hepatic resection. Forty-five (83%) minor hepatic resections were performed. Four (7%) peroperative deaths (within 30 days following surgery) were recorded. During follow-up it was noted that hepatocellular carcinoma recurred in 24 patients (44%) and local recurrence was the most frequent event. Mean disease free interval was 19 months after surgery. By multivariate analysis only vascular invasion proved to be statistically significant to HCC recurrence and survival. The recurrence rate of HCC in patients undergoing liver resection is high and long-term survival is long. An accurate analysis of risk factors for HCC recurrence after liver resection is of the utmost importance and further treatment alternative to and/or in association with surgery requires consideration.

Published
1999

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