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3. [Evaluation of the cardiac and peripheral vascular effects of the administration of single-dose enalapril and captopril in essential arterial hypertension].

Author

Longhini C, Ansani L, Musacci GF, Vaccari M, Fraccaroli GP, Mele D, Aggio S, and Baracca E

Subjects
Adult, Aged, Arm, Blood Pressure drug effects, Captopril therapeutic use, Echocardiography, Enalapril therapeutic use, Female, Humans, Male, Middle Aged, Plethysmography, Impedance, Time Factors, Vascular Resistance drug effects, Captopril administration & dosage, Enalapril administration & dosage, Hemodynamics drug effects, Hypertension drug therapy
Abstract

The effects of single orally-administered dose of enalapril and captopril on central and district-peripheral circulations have been studied in 20 patients with essential arterial hypertension. Either drug caused a decrease in arterial pressure, telesystolic and telediastolic parietal stress, and a reduction in the peripheral vascular resistance of upper limb district. Furthermore, at the upper limb district level, increases in arterial flow and venous-system capacity have been observed. The entity of these modifications induced by enalapril and captopril appeared comparable, according to the respective peak-time and used dosages. Under this study conditions, the difference between the drugs resulted to be essentially of chronological nature.

Published
1989

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