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A TV Dante – Cantos I-VIII (1989), the TV miniseries co-directed by Peter Greenaway and Tom Phillips, consists in a TV remediation of the first eight cantos from Dante’s Inferno. Taking inspiration from Phillips’ formerly work of Inferno’s illustration and translation (1983), Greenaway unfolds, through video, the metaliterature polysemy of the Italian poet. The essay reflects on Greenaway’s innovative pluricodical paraphrase of Dante’s hell. Within the television frame, thanks to Paintbox graphics, he reconstructs an hypertextual layout which reminds of renowned scholastic editions of the text, but also combine orality, written text, documentary images with original ones, soundtrack and pop-up boxes with extra-diegetic comments. Therefore, the essay analyses some of the series episodes in which different forms of experience merge together.

The migrant and refugee population present a high risk of developing mental disorders due to the difficulties associated with abandoning their own nation and culture and following often very dramatic migratory journeys. The experience of migration can be complex and stressful, linked to events before departure, during the journey and transit and after arrival. We present the case of the application of a cognitive behavioral approach to a young migrant from Cameroon, with strong symptoms of discomfort and serious difficulties in entering the Extraordinary Reception Center (CAS). The approach to the treatment involved the use of Protect, Beck Depression Inventory and List of Migration Experiences (LiMes). These tests are associated with clinical interviews where the presence of a post-traumatic stress disorder in comorbidity with a depressive syndrome emerged. The intervention was developed in different phases: psychoeducation, relaxation, cognitive restructuring, and narrative exposition technique. At the end of therapy, the interviews and the re-administered tests showed a clear general improvement in the migrant's state of health. There were no flashbacks, their ability to concentrate increased, their sleep was regularised and social relationships resumed. [ABSTRACT FROM AUTHOR]

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The modification and recognition of 5‐methylcytosine (m5C) are involved in the initiation and progression of various tumor types. However, the precise role and potential mechanism of Y‐box‐binding protein 1 (YBX1) in esophageal squamous cell carcinoma (ESCC) remains unclear. Here, it is found that YBX1 is frequently upregulated in ESCC compared with matched nontumor tissues. Gain‐ and loss‐of‐function assays show that YBX1 promoted the proliferation and metastasis of ESCC cells both in vitro and in vivo. Functional studies revealed that NOP2/Sun RNA methyltransferase family member 2 (NSUN2) is a critical RNA methyltransferase that facilitates YBX1‐mediated ESCC progression. Mechanistically, integrated analysis based on RNA immunoprecipitation sequencing (RIP‐seq) and m5C methylated RNA immunoprecipitation and sequencing (MeRIP‐seq) assays identified spermine oxidase (SMOX) as a target gene containing an m5C site in its coding sequence (CDS) region, which coincided well with the binding site of YBX1. Overexpression of SMOX‐WT but not SMOX‐Mut partially restored the proliferation and invasion ability of ESCC cells curbed by YBX1 knockdown. Moreover, YBX1 activated the mTORC1 signaling pathway by stabilizing SMOX mRNA. The study reveals that YBX1 promotes ESCC development by stabilizing SMOX mRNA in an m5C‐dependent manner, thus providing a valuable therapeutic target for ESCC. [ABSTRACT FROM AUTHOR]

Autoimmune uveitis (AU) is a kind of immune‐mediated disease resulting in irreversible ocular damage and even permanent vision loss. However, the precise mechanism underlying dynamic immune changes contributing to disease initiation and progression of AU remains unclear. Here, we induced an experimental AU (EAU) model with IRBP651‐670 and found that day[D]14 was the inflammatory summit with remarking clinical and histopathological manifestations and the activation of retinal microglia exhibited a time‐dependent pattern in the EAU course. We conducted single‐cell RNA sequencing of retinal immune cells in EAU mice at four time points and found microglia constituting the largest proportion, especially on D14. A novel inflammatory subtype (Cd74high Ccl5high) of retinal microglia was identified at the disease peak that was closely associated with modulating immune responses. In vitro experiments indicated that inflammatory stimuli induced proinflammatory microglia with the upregulation of CD74 and CCL5, and CD74 overexpression in microglia elicited their proinflammatory phenotype via nuclear factor‐kappa B signaling that could be attenuated by the treatment of neutralizing CCL5 antibody to a certain extent. In‐vivo blockade of Cd74 and Ccl5 effectively alleviated retinal microglial activation and disease phenotype of EAU. Therefore, we propose targeting CD74 and CCL5 of retinal microglia as promising strategies for AU treatment. [ABSTRACT FROM AUTHOR]

Amyloidosis reactive to chronic inflammation (AA amyloidosis) is a rare type of systemic amyloidosis, with prevalent renal involvement and a generally good overall survival (OS). However, progression to end-stage renal failure is frequent. Compared to other types of systemic amyloidosis, the role of prognostic biomarkers has been poorly explored in AA amyloidosis. Moreover, validated staging systems for the identification of patients with a more advanced disease are lacking. The acute phase reactant serum amyloid A (SAA) is the amyloid precursor protein and its concentration is associated with outcome. SAA concentration <10 mg/L after treatment translates in longer OS and lower incidence of end-stage renal failure. Boston researchers proposed a staging system for OS using estimated glomerular filtration rate (eGFR; cut-off, <35 mL/min/1.73 m2) and erythrocyte sedimentation rate (ESR; cut-off, >80 mm/h). Although it lacks validation, this staging system identified three groups with significant different OS. Pavia and Heidelberg researchers identified and validated a staging system for OS based on eGFR (cut-off, <45 mL/min/1.73 m2), serum albumin (cutoff, <30 g/L) and natriuretic peptides [type-B natriuretic peptide (BNP)] cut-off, >130 ng/L and/or N-terminal BNP (NT-proBNP) cut-off, >1000 ng/L). This staging system identified patients with low risk (5-year survival rate: 84%), intermediate risk (5-year survival rate: 55%) and high risk (5-year survival rate: 12%). Moreover, they proposed and validated a renal staging system using proteinuria (cut-off, >3 g/24h) and eGFR (cut-off, <35 mL/min/1.73m2). These data confirm the central role of the clinical laboratory in clinical management of systemic AA amyloidosis. [ABSTRACT FROM AUTHOR]

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Copyright of Annali di Storia delle Università Italiane is the property of CISUI: Centro Interuniversitario per la Storia delle Universita Italiane and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article delves into Tommaso Landolfi's evolving translation strategies in regard to Russian poetry, with a particular focus on the influence exerted on him by two Italian slavists and translators, Renato Poggioli and Angelo Maria Ripellino. During the initial phase of Landolfi's activity, the profound influence of Renato Poggioli becomes evident. This is exemplified by Landolfi's translations from the 1930s and 1940s, as well as the rigid prescriptions expressed in his reviews of books translated by others. Subsequently, Landolfi undergoes a phase of re-evaluation, as evidenced by his review of Ripellino's 'literal' translations and, most notably, by his first volume of translations of Pushkin (Einaudi 1960). In this book, Landolfi explores a wide range of strategies, particularly regarding the metrical organisation of the texts, without adhering to one specific approach. Ultimately, in his last two books of translations, Landolfi successfully amalgamates the contrasting models of Poggioli and Ripellino, culminating in the development of his own distinctive strategy. [ABSTRACT FROM AUTHOR]

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From painting to newspapers, from literature to homiletics, Victorian culture stigmatised the figure of the ‘fallen woman’ as it was considered a dangerous menace for a respectable society. For this reason, especially in the working class context, the mothers of illegitimate children were often marginalised even within their family circles. The Foundling Hospital aimed to house their ‘blank children’, teach them to read and prepare them for manual work, on condition that the mothers severed every link with their sons and daughters. Starting from the definition of ‘agency’ given by Anthony Giddens, this paper aims to demonstrate how letter writing became a powerful instrument of agency for the mothers who had their children admitted at the Foundling Hospital in mid-XIX century London. Letters became for them a way to overcome the strict rules of the institution and reaffirm their individuality in a context that considered them passive subjects.

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Copyright of JLIS.it: Italian Journal of Library, Archives & Information Science is the property of Firenze University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The digitization project Giving a new voice to sources. Communicate humanistic research for all aims to make available to the scientific community the audio archive of the Bruno Kessler Foundation's Library, which preserves the recordings of the conference activities of the two humanistic research centers of the Foundation. The project represents, at least in Italy, one of the first attempts to realize a virtual space devoted to audio archival sources researchable freely online to avoid the deterioration of a cultural heritage of extremely scientific relevance, leading to its conservation and availability. The deterioration of the analogue media of the archival collection makes the digitization a matter of survival which allows a diffusion otherwise unthinkable. The accessibility to the audio archival sources allows for enlarging the number of scholars and students that can benefit from the collection for the research. It also allows general users to approach the cultural contents of the humanities. The paper aims to describe the goals, the phases of realization of the project, the methodological problems due to the critical issues of the material supports, the descriptive analysis of the contents, and the opening of the database. The first part of the essay describes the history of the audio archive of the library. This archive covers an extensive period from 1974 to the new Millennium and is composed of the reels and compact audio cassette. The second part analyses the phases of work of the project, from the preliminary analysis of the support to the conversion and the digital reworking. The last part is dedicated to the method adopted in the compilation of metadata of the files and to the description of the structure of the database, as well as his research functions and the descriptive scheme of each audio. [ABSTRACT FROM AUTHOR]

The analysis of Isocrates’ reflection on ἀλήθεια at the beginning of the proem of the Encomium of Helen (4-5) offers a contribution to the understanding of the speech, intending to emphasise both its unitary structure and its specific character as a school text, which is aimed at teaching the norms that oversee praise, that are constructed, enunciated and applied at the very act of writing. The article proves that the search for the truth of the praise, intended as the search for an exemplary discourse of praise due to its subject, its structure, and the interweaving of theory and rhetorical practice, is a search programmatically indicated in a fundamental junction of the proem and can be referred to as the unifying feature of the Encomium of Helen as a school text, that is, a text drafted according to that technique of composition and, at the same time, of reflection on the discourse in fieri itself, which was typical of Isocrates’ teaching. [ABSTRACT FROM AUTHOR]

Copyright of L'Idomeneo is the property of Salento University Publishing, Dipartimento di Beni Culturali and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The essay reviews the cultural dynamics, authors and texts that marked Seneca’s great fortune in Elizabethan theater, an almost unique case in all of Europe during the XVIth Century. [ABSTRACT FROM AUTHOR]

The article presents a case study of engagement strategies in university foreign language teaching and learning. A number of communicative (cooperation, interdependence, time management) and emotional (inquiry-project-based learning and climax) engagement tools are illustrated and their integrated effect through observer-participants is reported. The concluding reflection supports the need to create learning environments that are coherent and akin to a pedagogical paradigm that is aware of the connection between the methodologies employed and interpersonal relationships. [ABSTRACT FROM AUTHOR]

Shakespeare’s play Julius Caesar emphasises the connection between rhetoric and politics. Some scholars, like Gayle Greene and Kim Ballard, point out that rhetoric in Julius Caesar is extremely important for the central political problems and character analysis. They also argue that Shakespeare implicitly criticises and condemns rhetoric that hides moral and political truth. Language is the most influential tool for seizing power in the play. Shakespeare well understands that power comes from those politicians who know how to manipulate the passions of the common people. Shakespeare’s soldiers are at the same time skilful politicians who, by manipulating particular words and gestures, try to attain their own ambitious goals. Funeral speeches offer Brutus and Antony a chance to convince people of the value of their own ideology through the power of spoken words. Describing Caesar’s murder as the result of the conspirators’ efforts to maintain order in Rome, Brutus uses prose and parallelisms to create a sense of balance. Using blank verse, apostrophe, repetition and irony, Antony affects the feelings of the Roman people and causes them to revolt. Shakespeare emphasises that mastering rhetoric results in strong political power and control.

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Copyright of Philologus -- Zeitschrift für Antike Literatur und Ihre Rezeption is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Sociologia Italiana is the property of EGEA S.p.A and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The article aims to discuss if and how medical labels and practices create sex-anatomical standards with respect to which those who do not align with them are labeled as "abnormal", thus also legitimizing some forms of violence and social marginalization. The case study of the German legal framework, where the third sex registry has recently found space, will then be explored to reflect whether nonnormative bodies are liberated or governed, with related normalizing repercussions, through their legal recognition. [ABSTRACT FROM AUTHOR]

Copyright of Italica is the property of University of Illinois Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The essay offers a reflection on the way in which invasion as a recurring topos in science fiction is reshaped in Nnedi Okorafor’s Lagoon, narrating the alien landing in Lagos. Comparing the novel with the paradigmatic model mostly provided by H.G. Wells’s The War of the Worlds, I intend to show how an important link with consolidated and familiar models is maintained, while at the same time a new approach is proposed in the light of the characteristics of Africanfuturism, a movement of which Okorafor is one of the most vocal representatives. Like other writers from Africa, she works on the process of Othering by proposing an anti-colonial and postcolonial viewpoint and shaping a narrative that interweaves science fiction, eco-fiction, petrofiction and cli-fi, combining different mythologies and folkloric figurations in the portrayal of an invaded city that is radically different from London, though presented as a global metropolis. [ABSTRACT FROM AUTHOR]

The 15th-century ms. Bodl. Barocci 216 preserves an unknown excerptum on punctuation attributed to the most renowned ancient grammarian in the field, Nicanor of Alexandria. This paper offers the first critical edition of this short excerptum, showing that it does derive from Nicanor's work, and probably from the epitome of his Περὶ στιγμῆς τῆς καθόλου, of which only a few fragments are extant today. The excerptum thus offers new elements concerning Nicanor's punctuation system, as well as the grammarian's exegesis of various poetic texts – prominent amongst these are a passage from Aristophanes' Ecclesiazusae where it restores a correct reading (conjectured in the 18th century), and a new poetic fragment possibly belonging to the comic genre. [ABSTRACT FROM AUTHOR]