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Introduction. Dysbiosis microbiota is considered as one of the consequences and impacts of high uremic toxins in patients with Chronic Kidney Disease (CKD), which can lead to an increased risk of progression and mortality. The aim of this systematic review and meta-analysis was to perform quantitative effect of microbiota modulation for estimated Glomerular Filtration Rate (eGFR), uremic toxin (total-p cresyl/total pCS), and inflammatory marker (hs-CRP) outcome among CKD patients. Methods. Article searches were conducted from PubMed, ScienceDirect, and Cochrane Library data sources from 2010-2022. Assessment of article quality follows the rules of PRISMA (Preferred Reporting Items in Systematic Review and Meta-Analysis). Only randomized controlled trial (RCT) articles investigating the effect of symbiotic, prebiotic, of probiotic for CKD were included in the analysis. Effect size quantify from Standardized Mean Difference (SMD), using a continuous random effect model and described in the forest plot model. Results. A total of 17 RCT studies with a total 867 CKD stage 1-5 subjects (440 subjects in the intervention group and 427 subjects in the control group). The intervention duration ranging from 1-12 months. The studies included had varied on methodologies, with significant heterogenicity (I296,96%, p Conclusions. The administration of probiotic/prebiotic/symbiotic supplements to CKD patients resulted in significant improvements in e-GFR and reductions in total pCS. These results suggest the potential of symbiotic, prebiotic, and probiotic supplementation to improve CKD outcome.

Pola konsumsi makanan berlemak berlebih menimbulkan berbagai gangguan metabolik dan inflamasi sistemik sehingga memicu peningkatan penanda inflamasi, yaitu high sensitivity C-Reactive Protein (hs-CRP). Madu hutan Apis dorsata mengandung antioksidan tinggi, namun belum banyak penelitian mengenai aktifitas antioksidan madu hutan ini terhadap perubahan kadar hs-CRP di dalam darah. Penelitian bertujuan untuk mengetahui pengaruh pemberian madu hutan Apis dorsata terhadap kadar serum hs-CRP tikus Sprague dawley jantan diinduksi pakan tinggi lemak (PTL). Rancangan penelitian yaitu pre-post test with control group design. 15 ekor tikus jantan Sprague dawley dibagi dalam tikus kelompok kontrol negatif (K-), kontrol positif (K+) diinduksi PTL, dan perlakuan (P) diinduksi PTL + madu hutan Apis dorsata dosis 0,5 ml/200 g BB. Induksi PTL diberikan selama 30 hari dan madu selama 7 hari. Serum hs-CRP diambil dua kali, yaitu setelah pemberian PTL dan setelah pemberian madu, kemudian diukur menggunakan metode ELISA. Hasilnya menunjukkan kelompok tikus yang diberi PTL+intervensi madu hutan mengalami penurunan kadar hs-CRP yang signifikan (p=0,009). Hal ini menandakan efek antioksidan dan antiinflamasi pada madu hutan Apis dorsata dapat menurunkan kadar hs-CRP. Kesimpulannya, Madu hutan Apis dorsata dosis 0,5 ml/200 g BB mampu menurunkan kadar serum hs-CRP tikus Sprague dawley jantan yang diinduksi pakan tinggi lemak.

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Proses penuaan mempengaruhi peningkatan distribusi lemak abdominal dengan indikator lingkar pinggang (LP) dan rasio lingkar pinggang panggul (RLPP). Penimbunan lemak abdominal menyebabkan disfungsi jaringan adiposa sehingga mempengaruhi biomarker proinflamasi yaitu kadar serum high-sensitivity C-reactive Protein (hs-CRP). Penelitian bertujuan untuk mengetahui hubungan LP dan RLPP dengan kadar hs-CRP lansia wanita. Rancangan penelitian cross sectional pada 53 subjek dipilih secara consecutive sampling. Antropometri yang diukur adalah LP dan RLPP. Pengukuran kadar serum hs-CRP dianalisis dengan metode enyme-linked immunosorbent assay (ELISA). Wawancara yang dilakukan yaitu data diri, asupan, aktivitas fisik, dan riwayat konsumsi obat. Data asupan diperoleh dengan metode food recall 3x24 jam. Aktivitas fisik diperoleh menggunakan International Physical Activity Questionnaire (IPAQ). Analisis data digunakan uji korelasi Spearman. Hasil penelitian menunjukkan bahwa persentase LP pada lansia wanita yang berisiko sebesar 90,6%, RLPP yang berisiko sebesar 98,1%, dan kadar hs-CRP tinggi sebesar 30,2%. Terdapat hubungan positif antara LP dengan kadar serum hs-CRP (r=0,417 ; p=0,002). Dalam penelitian ini RLPP, aktivitas fisik, asupan energi, karbohidrat, protein, lemak, serat, vitamin A, vitamin C, vitamin D,vitamin E, dan selenium tidak berkorelasi dengan kadar hs-CRP. Simpulan penelitian ini adalah LP berkorelasi positif dengan kadar serum hs-CRP, namun RLPP tidak berkorelasi dengan kadar serum hs-CRP

The prevalence of central obesity in Indonesia is increasing every year. Based on data released by Riskesdas in 2018, there were 31% of the population aged 15 years and over suffer from central obesity, where the highest was found in the 45–54 years group (42.3%), followed by 44 years (39.2%) and 55–64 years group (39.1%). Central obesity can be measured by waist circumference or abdominal circumference, and it plays an important role in the occurrence of cardiovascular disease. Examining C-reactive protein (CRP) at low levels using high-sensitivity CRP (hs-CRP) methods will help to predict the risk of coronary heart disease. This study aimed to find the correlation between waist circumference and hs-CRP serum levels between the ages of 35 and 64. The study was an analytical observational with a cross-sectional approach attended by 25 respondents at Bhayangkara Hospital Tingkat I Raden Said Sukanto, Kramat Jati, East Jakarta, from October to November 2019. The waist circumference was measured with a metlin roll, and Prodia Laboratory took the blood to measure hs-CRP serum levels using ELISA methods. The data were analyzed using the Pearson correlation test. The results showed a correlation between waist circumference and hs-CRP serum levels with Sig. (2-tailed)=0.000 (p

Obesity is a condition where there is an abnormal or excess accumulation of fat in the body that is stored in adipose tissue. Obesity will affect adiponectin secretion. C-reactive protein is a globulin synthesized by hepatocytes, the production of CRP is induced by interleukin-6, interleukin-1 and tumor necrosis factor, which will then be secreted into the blood. The purpose of this study was to determine the relationship between inflammation and disorders of carbohydrate metabolism and lipid metabolism and to obtain data on High Sensitivity C-Reactive Protein levels as a marker of inflammation, blood glucose levels to assess impaired metabolism of glucose, cholesterol, triglycerides, LDL to assess lipid metabolism disorders. and knowing the relationship between High Sensitivity C-Reactive Protein with blood glucose and lipid profiles (total cholesterol, triglycerides and LDL) in obese students of the Faculty of Pharmacy, Pancasila University. This study was conducted using an observational method with a study design cross-sectional with consecutive sampling where the researchers measured obesity indicators (weight, height, waist circumference), C-Reactive Protein (CRP) levels and lipid profile. The statistical tests used in this study were Kolmogorov Smirnov, Leaven's test and Spearman's. Characteristics of respondents based on body mass index parameters obtained at 27.54 kg/m². The frequency distribution on the gender parameter is the most with female sex as much as 74.1%. The average abdominal circumference is 91.97 cm. It is known that on average 48.1% of obese pharmacy students experienced hyperglycemia, 48.1% had hypercholeterolemia, 37% hypertriglyceridemia, 88.9% hyperbetalipoprotenemia and 29.6% students had hs-CRP levels > 3 mg/L. There was a significant relationship between hs-CRP and body mass index (r = 0.503 and p = 0.007) and a significant relationship was also found between body mass index and diastolic blood pressure (r = 0.506 and p = 0.007). It can be concluded that body mass index (BMI) is correlated with hs-CRP and diastolic blood pressure. [ABSTRACT FROM AUTHOR]

Latar belakang. Anak dengan riwayat berat lahir rendah (BLR) kecil masa kehamilan (KMK) memiliki peningkatan risiko menderita hipertensi dan gangguan kardiovaskular di kemudian hari. High sensitivity C-reactive protein (hs-CRP) memengaruhi kerusakan pembuluh darah yang mengakibatkan peningkatan tekanan darah. Tujuan. Menganalisis hubungan hs-CRP dengan berat lahir dan tekanan darah pada anak dengan riwayat BLR KMK. Metode. Penelitian dengan desain potong lintang dilakukan dari bulan Oktober - Desember 2018 di Manado. Kriteria inklusi adalah anak dengan riwayat BLR KMK, lahir pada tahun 2004-2009 di Rumah Sakit Umum Pusat Kandou, berdomisili di Manado, memiliki catatan medis lengkap, status gizi baik, dan mendapat persetujuan dari orang tua. Kriteria eksklusi adalah anak yang memiliki riwayat penyakit ginjal, sakit dan mengonsumsi obat-obatan dalam 2 minggu terakhir. Pengukuran Hs-CRP digunakan metode imunonephelometric dengan Dade Behring kit. Data dianalisis menggunakan korelasi Pearson dan uji regresi linier sederhana. Hasil. Total 40 anak dengan riwayat BLR KMK terdiri dari 16 anak laki-laki dan 24 anak perempuan. Rerata berat lahir adalah 2338,75 gram dan rerata kadar hs-CRP adalah 1,3158 mg/L. Terdapat hubungan negatif antara hs-CRP dan berat lahir (r=-0,275; p=0,043), hubungan positif antara hs-CRP dan tekanan darah sistolik (TDS) (r=0,559; p

Latar belakang. Hubungan antara kadar asam urat dengan sindrom metabolik banyak diteliti akhir-akhir ini. Asam urat juga menghambat proliferasi sel endotel dan menstimulasi produksi C-reactive protein (CRP) pada sel endotel. Interleukin-6 (IL-6) berasal dari jaringan adiposa yang menyebabkan peningkatan CRP. Tujuan. Menganalisis hubungan antara kadar asam urat, IL-6, dan hs-CRP pada anak obes. Metode. Kami melakukan penelitian potong lintang pada bulan Oktober 2015 sampai Desember 2015. Subyek anak obes berumur 6-12 tahun. Informed consent diberikan oleh orang tua. Penelitian ini telah disetujui oleh Komite Etik penelitian FK Unsrat. Hubungan antara asam urat, IL-6, dan hs-CRP diuji dengan uji Pearson dan regresi linear. Data dianalisis dengan software SPSS versi 22.0, nilai p

AbstrakPenelitian ini bertujuan menganalisis hubungan antara hs-CRP dengan faktor resiko kardiovaskuler klasik pada pasien dengan infark miokard akut. Penelitian ini merupakan subgroup analisis pada penderita infark miokard akut yang dirawat di RSUP Dr.M.Djamil mulai Januari-April 2013. Faktor resiko kardiovaskuler sebagai variabel independen berupa umur, riwayat hipertensi, diabetes, merokok, dan dislipidemia. Pengukuran IMT, profil lipid, dan gula darah random diambil saat pasien masuk dan diperiksa di Laboratorium Sentral RSUP Dr. M. Djamil Padang. Variabel dependen hs-CRP diambil dalam 24-36 jam rawatan dan diperiksa dengan metode ELISA. Data dianalisis dengan t-test dan uji korelasi Pearson. Hasil penelitian menunjukkan peningkatan hs-CRP, secara statistik berhubungan signifikan terhadap IMT (r=0,45; p=0,01), namun tidak berhubungan dengan faktor resiko kardiovaskuler lain seperti usia, hipertensi, diabetes, merokok, dan dislipidemia. Penelitian ini dapat disimpulkan bahwa peningkatan hs-CRP tidak berhubungan dengan faktor resiko kardiovaskuler klasik dan hs-CRP merupakan faktor resiko yang bersifat independen. Pemeriksaan ini bisa menjadi prediksi penyakit kardiovaskuler dan juga sebagai nilai prognostik pada pasien infark miokard akut.Abstract This study aimed to analyze the relationship between hs-CRP with classic cardiovascular risk factors in patients with acute myocardial infarction. This study was a subgroup analysis in patients with acute myocardial infarction who were hospitalized in Dr.M.Djamil hospital started from January to April 2013. Cardiovascular risk factors as independent variables were age, history of hypertension, diabetes, smoking, and dyslipidemia. Measurement of BMI, lipid profile, and random blood sugar were taken and examined at admission. The dependent variable hs-CRP were taken within 24-36 hours of admission and examined by ELISA. Data was analyzed by t-test and Pearson correlation test. The results showed an increase in hs-CRP and significantly related to BMI (r = 0.45; p=0.01), but not associated with other cardiovascular risk factors such as age, hypertension, diabetes, smoking, and dyslipidemia. It was concluded that increased hs-CRP was not associated with classic cardiovascular risk factors and hs-CRP is an independent risk factor. Hs-CRP examination could be a predictive of cardiovascular disease as well as prognostic value in patients with acute myocardial infarction.

Pendahuluan. Inflamasi dan stres oksidatif merupakan faktor risiko penyakit kardiovaskuler pada pasien penyakit ginjal kronis yang menjalani hemodialisis. Pasien hemodialisis kronis akan mengalami peningkatan kadar Hs-CRP. Hs-CRP merupakan marker inflamasi yang telah terbukti pada beberapa penelitian bermanfaat dalam memprediksi cardiovascular event. Pemberian N-Acetylcysteine (NAC) oral dapat digunakan sebagai strategi untuk menurunkan proses inflamasi yaitu disfungsi endotel dan stress oksidatif yang berperan pada atherosclerosis pada pasien hemodialsis. Pemberian NAC ini diharapkan dapat menurunkan angka morbiditas dan mortalitas karena penyakit kardiovaskuler. Metode. Penelitian eksperimen dengan Randomized Double Blind Controlled Trial pada 65 pasien hemodialisis kronis yang memenuhi kriteria inklusi di unit hemodialisis RS.Cipto Mangunkusumo Jakarta. Penelitian dilakukan pada Agustus sampai Oktober 2013 Hasil. Perlakuan dengan NAC oral selama 60 hari tidak memberikan perbedaan dibandingkan dengan plasebo. Analisis statistik dengan Mann Whitney menunjukkan bahwa tidak ada penurunan kadar Hs-CRP yang signifikan diantara kedua kelompok dengan p value Δ post1-baseline, Δ post2-baseline, and Δ post2-post1 kelompok NAC dibanding kelompok plasebo secara berurutan yaitu 0.796, 0.379 dan 0.712. Sementara itu, hasil uji Wilcoxon Signed Ranks untuk membandingkan penurunan kadar Hs-CRP pada tiap kelompok dalam tiga interval pengukuran Hs-CRP menunjukkan p value dari perbandingan kadar Hs-CRP untuk masing-masing kelompok baseline:Post1, baseline:Post2 dan Post1:Post2 (kelompok NAC Vs kelompok plasebo) secara berurutan 0.821vs0.651; 0.845vs0.358 dan 0.905vs0.789. Simpulan. Pemberian N-Acetylcysteine oral belum terbukti dapat menurunkan kadar Hs-CRP pada pasien hemodialisis kronis.

Pendahuluan. Peningkatan kadar fibrinogen yang menetap merupakan faktor risiko yang kuat untuk kejadian penyakit jantung koroner (PJK). Di sisi lain peningkatan fibrinogen plasma dapat merupakan respon fase akut. Pada kondisi ini peningkatan fibrinogen plasma bukan merupakan faktor risiko PJK. Penelitian ini bertujuan untuk mengetahui apakah kadar fibrinogen plasma meningkat pada fase akut dan tetap tinggi pada fase pasca akut dan mengetahui korelasi antara perubahan kadar fibrinogen plasma dengan perubahan aktivitas inflamasi dan fibrinolisis. Metode. Desain penelitian adalah studi prospektif dengan metode pengambilan sampel secara konsekutif. Pengambilan sampel fase akut untuk hs-CRP, aktivitas fibrinolisis, dan fibrinogen masing-masing diambil pada hari ke-2, 5, dan 6 pasca awitan sedangkan fase pasca akut diambil pada hari ke-13 pasca awitan. Fibrinogen diperiksa dengan metode Clauss, hs-CRP dengan metode ELISA, dan aktivitas fibrinolisis dengan metode ECLT manual. Analisis beda rerata dilakukan dengan uji t-berpasangan dengan alternatif uji wilcoxon. Analisis korelasi dengan uji Spearman. Hasil. Sampai akhir penelitian didapatkan 38 subyek sesuai kriteria inklusi dan eksklusi. Terdapat penurunan median kadar fibrinogen plasma pada fase pasca akut dibandingkan fase akut (415,5vs380,5mg/dL;p

Background: acute coronary syndrome (ACS) refers to any group of clinical symptom compatible with acute myocardial infarction (AMI). AMI is a major cause of death and disability worldwide with the greates risk of death within the first hours of AMI onset. Thus, the identification of novel biomarkers that improve current strategies and/or accurately identify subjects who are at risk of developing acute and chronic manifestation of cardiovascuar disease are desperately needed. Obsjective: this study was aimed to determine the accuracy diagnostic value of Fibrinogen and High Sensitivity C-Reactive Protein as a biomarker for Acute Coronary Syndrome Subjects and methods: an observational study with cross sectional approach, was conducted from February to July 2011 involving 76 male and female patients aged 35 to 80 years old for cases all well as controls. The biomarker measured were level of Fibrinogen and Hs-CRP. We used Receiver Operating Curve to determine the cut off test. We calculated of sensitivity, specificity, likelihood ratio, negative predictive value, and postive predictive value for biomarkers in combination and single. Results : the mean age in both groups was 57.5 year old. Level of the Fibrinogen in cases (5.81.56) was significantly different than control (3.781.78). concentration Hs-CRP in cases (4.041.94) was significantly different than control (1.981.25). both these biomarkers can be used as a diagnostic tool for Acute Coronary Syndrome in combination or single. Conclusion : the combination of Fibrinogen and Hs-CRP has the better diagnostic value that when used single.