1. [Biological activity and structure of antitumor compounds from Plantago media L].
- Author
-
Kunvári M, Páska C, László M, Orfi L, Kövesdi I, Eros D, Bökönyi G, Kéri G, and Gyurján I
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic isolation & purification, Cell Division drug effects, Cell Survival drug effects, ErbB Receptors drug effects, Flavonoids chemistry, Flavonoids isolation & purification, Glucosides chemistry, Glucosides isolation & purification, Humans, Molecular Conformation, Tumor Cells, Cultured, Antineoplastic Agents, Phytogenic pharmacology, Flavonoids pharmacology, Glucosides pharmacology, Phenols, Plantago, Plants, Medicinal
- Abstract
Tyrosine kinase inhibition and tumor growth inhibition activity of verbascoside and homoplantaginin are described. Both molecules proved to be equally significant inhibitors of isolated EGF-R tyrosine kinases, nevertheless their in vitro antiproliferative activity was variable in cellular assays. Their different inhibitory efficacies could be interpreted on the basis of conformational analysis and lipophilicity evaluation.
- Published
- 1999