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Introduction: SARS-CoV-2, a global pandemic that caused significant morbidity and mortality worldwide, even in the second wave. Multiple factors influence the disease burden including the vicious circulating virus characteristics, complications, limitations of the existing medicine, aggravation of the disease, and comorbidities in older people. In the present scenario, effective traditional treatment modalities should be scientifically applied to reduce massive disasters. Objectives: Here is the necessity to develop an appropriate treatment protocol from the field of Ayurvedic medicine. Diagnosis: It is a case study of a confirmed case of COVID-19/SARS-CoV-2 with uncontrolled diabetic history. Significant Clinical Findings: Presented intermittent fever, cough, headache, and dyspnea, along with symptoms associated with diabetes mellitus. Interventions: The case was successfully managed with Ama pachana (~carminative), Agnideepana (digestive), Jwara hara Oushdha, and simultaneously Prameha (~diabetes mellitus). Outcomes: The entire treatment course competed with a minimum number of hospitals stay compared with the national average. Ayurvedic management has a significant positive impact on the mental and physical quality of life. Both physical and mental scores got improved by more than 50% in this case. Marked radiological improvement noted, in this case, is associated with excellent quality of life after treatment. Conclusion: Ayurvedic management can be used in multiple levels preventive, curative, and restorative aspects.