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Unlabelled: Urinary tract infections (UTIs) occur in 3-5% of girls and 1% of boys. UTIs have been considered an important risk factor for the development of renal insufficiency, hypertension or end-stage renal disease. Hence, there is a need for early diagnosis and management of UTI to prevent renal scarring. The guidelines concerning the prophylactic treatment and the imaging studies have changed during the past year. It was believed that reflux predisposed to renal infection (pyelonephritis) by causing renal injury or scarring and that imaging studies in children with UTI were meant to identify anatomic abnormalities that predispose them to infection and renal scaring. Today, this concept is no longer prevalent and there is no recommendation to perform voiding cystourethrogram (VCUG] after every UTI., Aim: To examine parents' compliance to perform a VCUG test after hospitalization due to UTI and factors affecting their decision., Methods: We performed a retrospective study that included all children who were hospitalized and diagnosed with UTI at "Dana" Children's Medical Center during the period 1/2004 - 12/2005. Hospital file records were collected, and the relevant data were obtained. We collected data regarding the parents' compliance to perform a VCUG according to a telephone interview., Results: A total of 227 children participated in the study; 179 (78.85%) parents agreed to partake in the interview. Overall, 52% of the children didn't perform the VCUG because of concern about exposure to radiation (55.91%), fear and distress from pain during the test (43.03%), fear of irreversible damage to the urinary tract (40.86%), lack of relevant information (35.48%] and the primary pediatrician's recommendation to postpone the test. The remaining 48% conducted the test because of the hospital doctor's recommendation (94.18%), Primary pediatrician recommendation (94.18%) and because of the desire to terminate prophylactic treatment (63.95%). There is a significant correlation between the doctors' recommendation and the extent and clarity of their explanation to the parents' understanding of the importance of the test, to the parents' satisfaction from the explanation and to the compliance to perform the test., Conclusions: There is a need to improve the doctors' explanation regarding the performance of VCUG test post UTI. This will improve the patients' compliance to perform their post discharge recommendation.

Background: Feeding through tubes placed in the intestine is a useful way of nutritional support in a patient who is unable to eat but has a well functioning gastrointestinal system. Till 1980, the acceptable technique to place a gastrostomy tube was surgical. However, in the past twenty years percutaneous endoscopic gastrostomy (PEG) has replaced surgical gastrostomy in most settings., Goals: In this study we explored the indications, the age of the patients, the conditions in which the procedure took place and its outcome in children. The study aimed to investigate the effectiveness of this method in children., Methods: The data was gathered retrospectively according to information found in the files and a questionnaire the parents answered. Fifty-two children from the Tel Aviv Medical Center and from the Sheba Medical Center who underwent a PEG procedure were studied. The data gathered from the study included age, gender, origin, sequence of the procedure, indications, place, performers, complications and the effectiveness of the method according to parents' satisfaction and weight of the patient. In addition, the following parameters were studied: type of anesthesia, sort of antibiotics that were provided, number of cases in which enteral nutrition was given permanently or temporarily, type of formula that was given and the way it was introduced, number of failures and fundoplications., Results: Mean age of the children was 5.4 years. Ninety six percent of the procedures succeeded. The most common indications were failure to thrive (35%) and neurological disorders. In 56% of cases the performer was a gastroenterologist alone. When the procedures were performed by gastroenterologists, a lower rate of complications was seen than with a gastroenterologist and a surgeon (20.8% vs. 52.6% accordingly). In 57% of the children there were no complications observed. In addition, most of the complications which were observed were minor (abdominal pain, nausea and vomiting and reflux)., Conclusions: According to this study we concluded that PEG is a minimally invasive technique, associated with a low rate of severe complications and provides significant support for children who need enteral nutrition.

Sickle cell anemia results from a genetic defect that causes a structural change in the beta-chain hemoglobin. This change causes chronic anemia. In Israel, sickle cell disease primarily affects Arab communities. Recently, immigration from Africa exposed us to sickle cell disease in this population. Three cases are presented with a variety of symptoms of sickle cell disease in this population. Awareness of this disease and its clinical presentations will prompt early diagnosis and treatment that can help these patients to avoid further complications.

During the period 1989-1996, we retrospectively investigated 104 children and adolescents with Helicobacter pylori infection diagnosed by gastroscopy. The median age was 12.11 +/- 3.31 years, 55% were female and 45% male. The chief complaint of 92% of the children was abdominal pain, mainly epigastric. The typical macroscopic finding was nodular gastritis. The most common microscopic picture was chronic superficial gastritis with lymphatic follicles and the presence of Helicobacter pylori. We demonstrated correlation between these gastroscopic and histological findings. Children who suffered from peptic ulcer were older than those with nodular gastritis. Most of the Helicobacter pylori positive patients were treated with triple drug therapy. The combination of drugs changed throughout the years according to the newly accepted strategies in the treatment of Helicobacter pylori. The majority of children reported a decrease in symptoms on completion of therapy. Urea breath test was an efficient and convenient method for the follow-up of patients with Helicobacter pylori infection.

TNF alpha is a pro-inflammatory cytokine in Crohn's disease and it's neutralization is beneficial in patients with active disease. Remicade is a chimeric monoclonal anti-TNF antibody. Remicade is used in our center since December 1998 in 13 patients who were treated for active disease or fistula. We followed the patients and treatment results in order to estimate the efficacy and safety of this preparation. Response to treatment was measured by the Crohn's Disease Activity Index (CDAI) in patients treated due to active disease, or by the presence of discharge from external fistulae. Five out of seven patients with fistulae had less or no discharge after completing a course of 3 infusions. Four out of 6 patients treated due to active disease improved significantly after a single infusion. Five out of the six needed additional injections due to symptom recurrence. Intervals between infusions were 2 weeks--for fistulae patients to 32 weeks for patients with active disease. Adverse events for the 13 patients were usually mild except for 4 patients that suffered from anaphylactic shock, disseminated eruption (2) and eosinophilic pneumonitis. In summary, treatment of patients with active Crohn's disease or fistulae with monoclonal anti-TNF antibodies is an effective and relatively safe option after established treatment has failed. Analyzing the results of on going clinical trials and of the patients treated off-protocol will enable to establish new treatment strategies for patients with active Crohn's disease and fistulae.

Unlabelled: In order to examine the effect of reflux therapy on Hyper Reactive Airway Disease (HRAD) and apnea severity, 107 children, 78 with HRAD and 29 with apnea, underwent pH monitoring in the Pediatric Surgery Unit of Wolfson Hospital and the Dana Children's Hospital during the years 1995-1998. Pathological reflux was defined by means of the Boix-Ochoa and RI (Reflux Index) scores. In patients with positive reflux, anti-reflux treatment was initiated. Prior to and following pH monitoring, the respiratory status of all patients (both with and without reflux) was evaluated by a pediatric pulmonologist employing commonly used scores to determine severity., Results: Subject age ranged between one day and 15 years (mean: 15.44 +/- 29 months, median: 6.37 months). In HRAD, following anti-reflex treatment the reflux positive group showed a significant score improvement, from an average of 2.9 +/- 1.1 units to 1.54 +/- 1.2 units (p < 0.0001); a decrease in the number of patients treated with oral corticosteroids (p < 0.01); a close to significant decrease (p = 0.069) in the average dose of inhaled corticosteroids; and a decrease in the number of patients using bronchodilators (p = 0.042). The reflux-negative group, not treated for reflux, displayed no significant improvement, with only a decrease in the severity scores from 2.44 +/- 1.0 to 1.78 +/- 1.2 units (p = 0.14), and no change on any of the other parameters. In apnea, all patients improved, from an average score of 2.34 +/- 0.77 to 0.03 +/- 0.19 units (p < 0.0001), with no significant difference between the reflux positive and the reflux negative groups. In view of these findings, it is postulated that anti-reflux therapy may have an additive effect on HRAD severity, beyond that of spontaneous respiratory improvement. We therefore find it appropriate for every severe HRAD patient (frequent exacerbations or high corticosteroid dose) to undergo pH monitoring in order to treat those with proven reflux. In respect to apnea, we cannot attribute any significance to the existence of reflux or to anti-reflux treatment.

During 1990-1997 we investigated 201 children with gastrointestinal bleeding. Average age was 3.9 +/- 6 years; 57.2% were males. There were 129 (64.2%) cases of lower and 72 (35.8%) of upper GI bleeding. Complications of upper GI bleeding were more severe than those of the lower: 6 of 8 (75%) patients who deteriorated into hypovolemic shock had upper GI bleeding; 40 of 50 (80%) who required i.v. fluids (crystaloids and/or blood) had also bled from the upper GI tract; but anemia was more frequent (27.7% vs 17%) in lower GI bleeding. The main etiology for upper GI bleeding was peptic ulcer, and for lower GI bleeding anal fissure. Mean hospital stay for upper GI bleeding was 3.87 +/- 2.61 days vs 3.40 +/- 3.51 for lower (not significant). In 34% the etiology of bleeding was undetermined. Although current literature refers to intussusception as a common cause of GI bleeding in infancy, we had no such cases. This difference might have resulted from our diagnoses being made earlier, before mucosal damage could have caused bleeding. We found polyps the second most frequent cause for lower GI bleeding in children. Endoscopy was of more benefit than any other diagnostic method, while barium enema and ultrasound had no diagnostic value. Stool culture did not contribute to diagnosis: only 3 of 36 were positive, so it is only necessary when there is bloody diarrhea.

The incidence of Crohn's disease has risen dramatically over the past few years. The peak age of onset is in late adolescence, but it rarely occurs in the first few years of life. We describe a 5-year-old boy with recurrent bouts of fever, aphthous stomatitis, and anemia which did not respond to routine antibiotic therapy. It was only after a few months, when the characteristic symptoms of inflammatory bowel disease (IBD): abdominal pain and diarrhea appeared, that the diagnosis of Crohn's disease was made. This case illustrates the difficulty in diagnosing IBD in young children. The presenting symptoms of IBD in children are often nonspecific and extra-intestinal. There is usually a low index of suspicion by the physician as to the possibility of IBD in a young child.

Exchange transfusion has an important role in the treatment of hyperbilirubinemia of the newborn. It is used in attempts to prevent kernicterus when bilirubin levels are high. We describe our experience in 203 exchange transfusions performed on 143 infants (81 males and 62 females) with hyperbilirubinemia during 1983-1992. In only 30% of cases was there a specific etiological diagnosis of the jaundice based on a positive Coombs test, G6PD deficiency, or the presence of sepsis or maternal diabetes; the rest were idiopathic. 57% of the neonates were premature (26-36 weeks of gestation). Premature neonates underwent more transfusions than full-term infants (1.6 vs 1.2). There was no direct death from exchange transfusion; morbidity was 6.3% (including bradycardia, apnea, thrombocytopenia, hypoglycemia and hyponatremia). Most complications occurred in preterm infants and those severely ill. All complications were treated immediately and there were no sequelae.

Intussusception, the invagination of a portion of the intestine into an adjacent segment, is the most common cause of intestinal obstruction in post neonatal children. Most cases are idiopathic, but in about 2-12% the intussusception evolves secondary to an underlying abnormality. Classically, there is sudden onset of attacks of screaming, accompanied by pallor, vomiting, and irritability in a previously health child. Some gradually become weaker and lethargic. We evaluated variations in presenting symptoms and outcome as related to age and time until admission. There were incidence peaks in the spring and autumn. 48% developed irritability, while 42% were described as apathetic. These results emphasize the importance of awareness that apathy can be a major presenting symptom. The younger the child, the greater the rate of success of reduction by hydrostatic pressure. In those admitted within 24 hours of onset, the rate of reduction was twice that in those admitted later. Awareness of atypical symptoms and early diagnosis may affect treatment and improve prognosis.