1. The association of fatty acid desaturase gene polymorphisms on long-chain polyunsaturated fatty acid composition in Indonesian infants
- Author
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Zakiudin Munasir, Muchtaruddin Mansyur, Herawati Sudoyo, Peter Rzehak, Conny Tanjung, Suzanna Immanuel, Eva Reischl, Roedi Irawan, Sri Rezeki Hadinegoro, Hans Demmelmair, Berthold Koletzko, and Damayanti Rusli Sjarif
- Subjects
Adult ,Fatty Acid Desaturases ,Male ,0301 basic medicine ,Genotype ,FADS1 ,FADS2 ,Medicine (miscellaneous) ,Physiology ,Blood lipids ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Asian People ,Fatty Acids, Omega-6 ,Fatty Acids, Omega-3 ,Humans ,Asia, Southeastern ,2. Zero hunger ,chemistry.chemical_classification ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Fads1 ,Fads2 ,Fads3 ,Polymorphisms ,Fetus ,Lc-pufa Composition ,Indonesia ,FADS3 ,Infant, Newborn ,Infant ,Fetal Blood ,3. Good health ,Original Research Communications ,fetus ,Fatty acid desaturase ,chemistry ,Blood chemistry ,Cord blood ,biology.protein ,Female ,LC-PUFA composition ,polymorphisms ,Polyunsaturated fatty acid - Abstract
Background Adequate availability of long-chain polyunsaturated fatty acids (LC-PUFAs) is important for human health from pregnancy to adulthood. Previous studies on fatty acid desaturase (FADS) gene single-nucleotide polymorphisms (SNPs) have been performed predominantly in Western populations and showed that FADS SNPs had a marked impact on LC-PUFA composition in blood and tissues. Objectives We aimed to investigate the influence of fetal FADS genotypes on LC-PUFA composition in umbilical artery plasma lipids in Indonesian infants. Design We performed a cross-sectional study to assess for these associations. Results A total of 12 cord plasma n–6 (ω-6) and n–3 (ω-3) fatty acids were analyzed for associations with 18 FADS gene cluster SNPs from 390 women with single parturition from the Indonesian Prospective Study of Atopic Dermatitis in Infants (ISADI). Fetal FADS genotypes influenced cord plasma LC-PUFA composition, but, in contrast to previous studies from Western populations, the quantitatively predominant SNPs were associated with lower LC-PUFA content. Conclusion To our knowledge, this study was the first in South East Asia on FADS genotypes and arterial cord blood fatty acids to show an association between fetal LC-PUFA composition and fetal FADS SNPs. The FADS genotype distribution differs markedly between different geographical populations. This trial was registered at clinicaltrials.gov as NCT02401178.
- Published
- 2018