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Changes in the pulmonary diffusing capacity for CO (Dl) in pregnant women have been reported previously. According to these findings, the effects of various steroid hormones (Oestriol succinate, Progesterone, Prednisolone succinate and Aldactone®) were tested by the single-breath technique of Ogilvie, Forster, Blakemore and Morton. Measurements in ten healthy women were performed one, two and twenty-four hours after intravenous administration of 40 mg Oestriolsuccinat. Significant decreases of 8.8% in the first hour and 12.4% in the second were found. The values normalized within 24 hours. Controls of Dl were taken 24 and 48 hours after the daily i. m. injection of 50 mg progesterone for two days in ten healthy young women. No change was observed in the first 24 hours. However, there was a slight significant increase of the mean value by 4.2% after 48 hours. The effect of 100 mg Prednisolone succinate and 200 mg Aldactone® were tested because of their great importance in the management of cardiopulmonary diseases. No substance showed an effect on Dl, one and two hours after intravenous administration. [ABSTRACT FROM AUTHOR]