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Zielsetzung: Diese Studie befasst sich mit dem möglichen Einfluss einer Lymphgefäß- oder Blutgefäßinfiltration auf das Gesamtüberleben von Patienten mit einem Nicht-Kleinzelligem Bronchialkarzinom (NSCLC), die weder nodale noch hämatogene Metastasen aufwiesen. [for full text, please go to the a.m. URL], 21. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie

Einleitung: Es besteht die allgemeine Annahme, dass multiviszerale Resektionen (MVR) im Falle von fortgeschrittenen Pankreaskarzinomen, mit einer erhöhten Morbiditätsrate assoziiert sind. Der onkologische Vorteil durch diese Operation für die Patienten ist umstritten. Material und [for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Einleitung: Pankreas-erhaltende Duodenektomien (PPD) sind Eingriffe, die in aller Regel bei gutartigen Tumoren des Duodenums zur Anwendung kommen. Dies gilt besonders für Patienten mit hereditären Polyposis-Syndromen. Patienten mit einer familiären Adenomatosis Polyposis (FAP) entwickeln[for full text, please go to the a.m. URL], 129. Kongress der Deutschen Gesellschaft für Chirurgie

Self-assembly of nanoparticles is one of the most promising methods for the preparation of novel materials and devices with exceptional properties. In order to control nanoparticles self-assembly, an understanding of their interactions is absolutely necessary. One convenient way to achieve a control on their interaction is through the use of external fields. Here we provide two different examples of how interparticle interactions are affected by interactions with external fields. In the first case, magnetic fields are used to induce dipolar interactions among concentrated suspension of superparamagnetic nanocolloids, which cause them to self-assemble into dense chain-like anisotropic structures, used as templates for the growth of porous materials with tunable properties. In the second case, it is shown how more commonly employed but less understood flow fields interact with clusters of particles, and lead to their restructuring or disassembly depending upon the shear stress applied.

Hepatocellular carcinoma is a common malignancy globally with increasing incidence and significant cancer mortality. Delayed detection leads to a poor prognosis with median survival of < 10 months. Only very few patients qualify for a resection or transplantation. Even local treatments are only useful in very few selected patients. No strong evidence exists on beneficial effect of any chemotherapy, hormonal therapy, or immunotherapy in advanced HCC-patients. Thus finding effective systemic treatments for non-resectable HCC has become a great challenge. HTI-286 is a synthetic analogue of hemiasterlin and depolymerises microtubules. In several human xenograft models HTI-286 has shown significant antitumor activity. We have analyzed antitumor effect of HTI-286 alone or in combination with CCI779 on hepatic tumor cells in an in-vitro and in-vivo model. Proliferation of all hepatic tumor cells (MH, Hep3B und HepG2) was inhibited in-vitro. Primary human hepatocytes were not affected by HTI-286. A significant tumor reduction was seen in-vivo in the HTI and HTI/ CCI779 group. HTI inhibits tumor cell proliferation in-vitro and in-vivo. CCI779 seems to have an additive effect on tumor reduction. HTI is to be considered as a promising drug in the treatment of advanced HCC.