1. [Histochemical differential diagnosis of intestinal metaplasia of the stomach--new sialic acid stains].
- Author
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Meessen D, Veh RW, Kuntz HD, and May B
- Subjects
- Biopsy, Chemical Phenomena, Chemistry, Diagnosis, Differential, Gastric Mucosa analysis, Histocytochemistry, Humans, Metaplasia, Periodic Acid-Schiff Reaction, Precancerous Conditions pathology, Sialic Acids analysis, Staining and Labeling, Stomach pathology
- Abstract
tients with precancerous lesions of the stomach should be followed regularly, since the prognosis of gastric carcinoma is still rather bad. A histochemical method implaying the use of sialic acid is described, which allows differentiation of two forms of intestinal metaplasia of the gastric mucosa, exhibiting possibly different degrees of premalignancy . The two types of metaplastic areas produce, respectively, duodenum-like or colon-like goblet cell mucus. Probably only the latter type is to be classified as a premalignant lesion. This hypothesis is being supported by the fact, that during histochemical work-up of routine biopsy material of gastric mucosa intestinal metaplasia of the colon type was found only in two out of twenty cases of metaplasia.
- Published
- 1983