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2 results on '"Uicc stage"'

1. Epidemiologie und operative Behandlung des Pankreaskarzinoms im Flächenland Brandenburg: Analyse von 5418 Fällen.

Author

Mantke, R., Schneider, C., Weylandt, K., Gretschel, S., Marusch, F., Kube, R., Loew, A., Jaehn, P., Holmberg, C., and Hunger, R.

Subjects
*CLASSIFICATION, *TUMORS
Abstract

Background: Pancreatic cancer is the second most frequent cause of death among all forms of cancer in Germany with more than 19,000 deaths per year. The evaluation of the nationwide clinical cancer register aims to depict the reality of treatment and to improve the quality of treatment in the future by targeted analyses. Method: The data from the clinical cancer register of Brandenburg-Berlin for the diagnosis years 2001–2017 were analyzed with respect to the treatment of pancreatic cancer. Data from patients resident in the State of Brandenburg were evaluated with respect to epidemiological and therapeutic parameters. Results: A total of 5418 patients with pancreatic cancer were documented in the register from 2001 to 2017 and 49.6% of the patients were diagnosed as having the Union for International Cancer Control (UICC) stage IV. A pancreas resection was carried out in 26.4% of the cases. In cases of cancer of the head of the pancreas the most frequent procedure was a pylorus-preserving resection with 51.8% and a pancreatectomy was carried out in 9.4%. The R0 resection rate of all pancreatic cancers in the period from 2014 to 2017 was 61.9%. After R0 resection the 5‑year survival was 19%. Relevant multivariate survival factors were age, UICC stage and the residual (R) tumor classification. The case numbers per hospital had no influence on the absolute survival of patients operated on in the State of Brandenburg. Conclusion: The treatment reality in the State of Brandenburg for patients with pancreatic cancer corresponds to the results of international publications with respect to the key performance indicators investigated. A qualitative internationally comparable treatment of these patients is also possible in nonmetropolitan regions. [ABSTRACT FROM AUTHOR]

Published
2022
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2. Detektion und prognostische Relevanz des Nachweises disseminierter Tumorzellen bei Patienten mit duktalem Adenokarzinom des Pankreas

Author

Holger Kalthoff, Bernd Kremer, U. Grigoleit, and I. Vogel

Subjects
medicine.medical_specialty, business.industry, Stage ii, medicine.disease, Gastroenterology, Uicc stage, medicine.anatomical_structure, ddc: 610, Internal medicine, medicine, Adenocarcinoma, Bone marrow, Stage (cooking), Pancreas, Stage iv, business, Survival analysis
Abstract

Aim: The prognostic impact of disseminated tumour cells is controversially discussed. In our prospective analysis preoperatively taken blood and bone marrow samples of patients with ductal adenocarcinoma of the pancreas were evaluated for disseminated tumour cells by Cytoke-ratin 20 (CK 20) RT-PCR. Material and methods: 162 bone marrow and 184 blood samples were taken from 207 patients (1992–2002). According to the UlCC-stages (1997) the distribution was: UICC stage I: 7 pat. (3.4%); II: 23 pat. (11%); III: 56 pat. (27%); IVa + b: 121 pat. (58,6%). Only 87 (42%) of the 207 patients were curatively (R0) resected. Patients follow up was between 3 and 69 months (mean: 19 months). Results: In both compartments detection of disseminated tumour cells increased with the UlCC-stage (bone marrow: I: 0%, II: 13.3%, III: 38.1%, IV: 38.0%; blood: I: 14.3%, II: 25.0%, III: 26.3%, IV: 37.9%). In either one compartment or in both compartments we found cells in 14.3% of stage I, 26.1% of stage II, 48.2% of stage III and in 51.2% of stage IV. Univariate survival analysis of all patients according to Kaplan-Meier revealed no statistically significant differences between patients with or without detection in the bone marrow (p = 0.4095), blood (p = 0.2147) and bone marrow and/or blood (p = 0.288), although the survival times of patients without disseminated tumour cells were in each analysis longer than in patients with tumour cells. When only the 87 curatively resected patients were analyzed separately, no significant differences could be observed (bone marrow: p = 0.6207, blood: p = 0.9385, bone marrow and/or blood: 0.4917). Summary: Disseminated tumour cells can be detected in patients with ductal pancreatic adenocarcinoma by CK 20 RT- PCR. Detection rates are UICC stage dependent, but survival analyses failed to demonstrate prognostic significance so far.

Published
2004

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